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Wakix (Pitolisant)

Brand

Wakix (Pitolisant)

Prescription Required

Strength
Qty
5mg
20mg
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  • Product Details

    Description

    Wakix is a drug used to treat excessive daytime sleepiness (EDS) in people with narcolepsy. People with narcolepsy fall asleep at inappropriate times throughout the day. People with narcolepsy have excessive drowsiness and trouble staying awake during the day.

    Wakix is a histamine-3 (H3) receptor antagonist and inverse agonist. Histamine is associated with sleepiness, so by blocking histamine receptors, Wakix helps to keep people awake.

    Directions

    Take Wakix once daily in the morning when waking up. There is a specific titration schedule that your doctor will follow:

    • 8.9 mg once daily during week 1
    • 17.8 mg once daily during week 2
    • 35.6 mg once daily during week 3; this is the maximum dose

    Ingredients

    The active ingredient is pitolisant.

    Interactions

    There are many potential drug-drug interactions with this medication, including

    • Apalutamide
    • Ajmaline
    • Antihistamines
    • Artemether and Lumefantrine
    • Benzodiazepines
    • Budesonide
    • Bupropion
    • Calcium Channel Blockers
    • Carbamazepine
    • Carbamazepine
    • Corticosteroids
    • Dacomitinib
    • Enzalutamide
    • Etoposide
    • Fluoxetine
    • Fosphenytoin
    • Haloperidol
    • Hormonal Contraceptives
    • Immunosuppressives
    • Levoketoconazole
    • Lumacaftor
    • Lumacaftor-ivacaftor
    • Macrolide antibiotics
    • Mirtazapine
    • Miscellaneous
    • Mitotane
    • Paroxetine
    • Peginterferon Alfa-2b
    • Phenobarbital
    • Phenytoin
    • Primidone
    • Promethazine
    • QT-prolonging Agents
    • Quinidine
    • Rifampin (rifampicin)
    • Statins
    • Steroids
    • Tipranavir

    Cautions

    Tell your doctor about kidney or liver problems before starting this drug. The dosage may need to be adjusted.

    Tell your doctor if you have a history of heart arrhythmia, specifically QT-prolongation, or if you take QT-prolonging drugs.

    Side Effects

    Common side effects may include:

    • Abdominal pain
    • Abnormal behavior
    • Abnormal dreams
    • Anaphylaxis
    • Anxiety
    • Bipolar mood disorder
    • Cataplexy
    • Decreased appetite
    • Depressed mood
    • Depression
    • Epilepsy
    • Fatigue
    • Hallucination
    • Headache
    • Hypersensitivity reaction
    • Increased heart rate
    • Insomnia
    • Irritability
    • Lack of emotion
    • Migraine
    • Musculoskeletal pain
    • Nausea
    • Nightmares
    • Prolonged QT interval on ECG
    • Pruritus
    • Skin rash
    • Sleep disorder
    • Sleep disturbance
    • Sleep paralysis
    • Sleep talking
    • Suicidal ideation
    • Suicidal tendencies
    • Tachycardia
    • Upper respiratory tract infection
    • Weight gain
    • Xerostomia

    References

    Wakix [package insert]. Plymouth Meeting, PA: Bioprojet Pharma; 2019.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13797

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