Description
Wegovy (semaglutide) is a prescription medication primarily used for weight loss in adults and teenagers who are obese, as well as overweight adults with additional weight-related medical problems such as high blood pressure, type 2 diabetes, or high cholesterol. This medication works by regulating appetite and reducing calorie intake, aiding in both weight loss and weight management.
Semaglutide, a synthetic version of the hormone glucagon-like peptide 1 (GLP-1) naturally released from the gut after eating, plays a crucial role in regulating blood sugar levels. This is particularly relevant for adults with an initial body mass index (BMI) of 30 kg/m2 or more (indicative of obesity) and 27 kg/m2 or more (indicative of overweight) in the presence of at least one weight-related comorbidity.
Before you buy Wegovy, it is essential to discuss its effectiveness for weight loss and potential side effects with your healthcare provider.
| Fact Table |
| Formula |
C187H291N45O59 |
| License |
EU EMA, US FDA |
| Bioavailability |
89% |
| Legal status |
Rx-Only |
| Chemical Name |
Semaglutide |
| Elimination half-life |
7 days |
| Dosage (Strength) |
0.5mg pen of 0.5mg/0.5ml, 0.25mg pens of 0.25mg/0.5ml, 1mg pens of 1mg/0.5ml, 1.7mg pens of 1.7mg/0.75ml, 2.4mg pens of 2.4mg/0.75ml |
| Pregnancy |
Not Recommended |
| Brands |
Wegovy |
| Protein binding |
More than 99% |
| PubChem CID |
56843331 |
| MedlinePlus |
a618008 |
| ChEBI |
167574 |
| ATC code |
A10BJ06 |
| DrugBank |
DB13928 |
| KEGG |
D10025 |
| Routes of administration |
Subcutaneous |
Directions
The initial administration of Wegovy injection starts with a dosage of 0.25 mg, administered weekly. This dosage remains constant throughout the initial four-week period. The dosage is systematically increased following a structured schedule:
- In the second month, the dosage is 0.5 mg weekly
- In the third month, the dosage progresses to 1.0 mg weekly
- The fourth month sees a further increase to 1.7 mg weekly
- From the fifth month onwards, the dosage stabilizes at the maintenance level of 2.4 mg weekly
Wegovy is administered via subcutaneous injection, which can be done in the abdomen, thigh, or upper arm. It is critical to adhere strictly to the instructions provided to ensure the correct technique of self-injection is used. This medication should be injected beneath the skin and not into a muscle or vein for optimal efficacy.
Ingredients
The active ingredient in Wegovy is Semaglutide.
Cautions
Avoid this medication if you have a history of thyroid tumors, specifically Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN 2).
Do not use it if you are allergic to semaglutide or any of its ingredients.
Inform your doctor about any history of stomach or intestinal disorders, pancreatitis, kidney disease, diabetic retinopathy, or mental health issues.
Be cautious about drug interactions, especially with diabetes medications.
Monitor blood sugar levels for signs of hypo- or hyperglycemia.
Never share an injection pen to prevent infection transmission.
Use a new, sterile needle for each injection.
Store the medication according to the instructions on the label, typically in a refrigerator at temperatures between 36°F to 46°F (2°C to 8°C). Avoid freezing and protect it from light. Discard the pen after use.
Interactions
Negative drug interactions may occur between Wegovy and 246 other prescription (Rx) or over-the-counter (OTC) medications. These include albuterol, amlodipine, aspirin, atorvastatin, bupropion, cyclobenzaprine, duloxetine (Cymbalta), famotidine, gabapentin, hydrochlorothiazide, hydroxyzine, ibuprofen, levothyroxine, lisinopril, losartan, meloxicam, metformin, montelukast, omeprazole, pantoprazole, prednisone, rosuvastatin, topiramate, trazodone, acetaminophen (Tylenol), Vitamin B12, Vitamin C, Vitamin D3, lisdexamfetamine (Vyvanse), and cetirizine (Zyrtec).
Side Effects
The most common side effects of Wegovy may include nausea, stomach (abdominal) pain, dizziness, stomach flu, diarrhea, headache, bloating, heartburn, vomiting, fatigue, belching, runny nose or sore throat, constipation, upset stomach, and gas.
References
Wegovy[Prescribing Information]. Bagsvaerd, Denmark: Novo Nordisk A/S; July 2023.
Frequently Asked Questions about Wegovy (Semaglutide)
What is Wegovy?
Wegovy (semaglutide) injection 2.4 mg is a prescription medicine for adults and children aged 12 years or older with obesity or some adults with excess weight who also have weight-related medical problems. It is used alongside a reduced-calorie meal plan and increased physical activity.
How does Wegovy work?
It mimics a hormone that regulates appetite and food intake, helping you eat less and potentially lose weight.
When can weight loss be expected with Wegovy?
Weight loss timelines vary, and it is best to discuss expectations with a healthcare provider.
What are common side effects?
These include nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, dizziness, feeling bloated, belching, gas, stomach flu, heartburn, and runny nose or sore throat.
Can I travel with Wegovy?
Yes, but keep the Wegovy pen in your carry-on when flying to prevent freezing.
How often is Wegovy taken?
It must be taken once a week, any time of day, with or without food.
Why are there different color pens?
Each dose (0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg) comes in its own color pen.
Should I take Wegovy with a meal?
It can be taken with or without food.
What if I miss a dose?
If the next scheduled dose is more than 2 days away, take the missed dose as soon as possible. If it is less than 2 days away, skip the missed dose and continue with the regular schedule.
How to dispose of used Wegovy pens?
Use an FDA-cleared sharps disposal container or a sturdy household container with a tight-fitting lid and dispose of it as per local regulations.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 14540
Prescription Required
