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Welireg (Belzutifan)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Belzutifan is a prescription medication used to treat von Hippel-Lindau (VHL) disease, which is a disease that can produce tumors that lead to renal cell carcinoma (RCC), central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors (pNET).

    Belzutifan belongs to a class of drugs known as hypoxia-inducible factor-2 alpha (HIF-2a) inhibitors. It works by blocking the activity of HIF-2a, a protein that promotes the growth of cancer cells by allowing them to adapt to low-oxygen conditions. By inhibiting HIF-2a, Belzutifan helps to suppress the growth and spread of tumors.

    Directions

    Do not stop or change directions without speaking to your doctor first.

    The usual dosage is 120 mg by mouth once daily. Since Welireg is supplied as 40 mg tablets, three tablets should be taken daily.


    Fact Table

    Formula

    C17H12F3NO4S

    License

    US DailyMed

    Bioavailability

    No Data Available

    Legal status

    Rx-Only

    Chemical Name

    Belzutifan

    Elimination half-life

    14 hours

    Dosage (Strength)

    -

    Pregnancy

    Consult Doctor

    Brands

    Welireg

    Protein binding

    45%

    PubChem CID

    117947097

    MedlinePlus

    a621047

    ChEBI

    No Data Available

    ATC code

    L01XX74

    DrugBank

    DB15463

    KEGG

    D11954

    Routes of administration

    By mouth

    Ingredients

    The active ingredient in Welireg is belzutifan.

    Interactions

    Common drug-drug interactions may include:

    • Acetohexamide
    • Acarbose
    • Albiglutide
    • Alogliptin
    • Atogepant
    • Bexagliflozin
    • Canagliflozin
    • CarBAMazepine
    • Chlorpropamide
    • CloZAPine
    • CYP2C19 Inhibitors
    • CYP3A4 Inducers
    • Dapagliflozin
    • Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
    • Dulaglutide
    • Empagliflozin
    • Ertugliflozin
    • Exenatide
    • First Generation Sulfonylureas
    • Gliclazide
    • Glimepiride
    • Glipizide
    • Glyburide (Glibenclamide)
    • Glucagon-Like Peptide-1 (GLP-1) Analogues
    • Hormonal Contraceptives
    • Incretin-Based Drugs
    • Linagliptin
    • Liraglutide
    • Lixisenatide
    • Metformin
    • Metiglinide Analogues
    • Miglitol
    • Nateglinide
    • NiMODipine
    • Pioglitazone
    • Pramlintide
    • Repaglinide
    • Rosiglitazone
    • Saxagliptin
    • Second Generation Sulfonylureas
    • Selpercatinib
    • Semaglutide
    • Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors
    • Sirolimus
    • Sitagliptin
    • Tacrolimus
    • Teplizumab
    • Thiazolidinediones
    • Tirzepatide
    • Tolazamide
    • Tolbutamide
    • Troglitazone
    • Ubrogepant

    Cautions

    Belzutifan may cause harm to unborn babies if used during pregnancy.

    Treatment with Welireg may cause anemia or hypoxia. Tell your doctor if you have trouble breathing at any point during therapy.

    Side Effects

    Common adverse reactions include:

    • Abdominal pain
    • Anemia
    • Arthralgia
    • Constipation
    • Cough
    • Decreased calcium
    • Decreased phosphate
    • Dehydration
    • Dizziness
    • Dyspnea
    • Edema
    • Fatigue
    • Flu-like symptoms
    • Headache
    • Hypertension
    • Hypoxia
    • Increased creatinine
    • Increased aspartate aminotransferase
    • Leukocytosis
    • Musculoskeletal pain
    • Myalgia
    • Nausea
    • Retinal detachment
    • Retinal vein occlusion
    • Upper respiratory tract infection
    • Visual impairment
    • Vomiting
    • Weight gain

    References

    1. Welireg [package insert]. Whitehouse Station, NJ: Merck; 2021.

    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13772

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