What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Xarelto (Rivaroxaban)
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Product Details
Description
XARELTO (Rivaroxaban) is a medication used to treat or prevent blood clots in a number of different medical conditions. Blood clots that form in the deep vein system may break off and become lodged in the capillaries of the lungs, brain, or other organs. Damage from blood clots may be permanent and can be fatal.
Xarelto may be prescribed for the following:
- Prevent stroke and systemic embolism in nonvalvular atrial fibrillation
- Prevent deep vein thrombosis (DVT) in patients undergoing knee or hip replacement surgery
- Prevent recurrence of deep vein thrombosis (DVT) or pulmonary embolism (PE)
- Treat deep vein thrombosis (DVT) and pulmonary embolism (PE)
XARELTO (Rivaroxaban) works by preventing the function of the clotting factor Xa. The body forms clots through a complex system of proteins called clotting factors, and by inhibiting factor Xa, XARELTO (Rivaroxaban) slows the formation of blood clots.
Fact Table
Formula
C19H18ClN3O5S
License
US FDA, EU EMA, US DailyMed
Bioavailability
80–100%
Legal status
Rx-Only
Chemical Name
Rivaroxaban
Elimination half-life
5–9 hours
Dosage (Strength)
2.5mg, 10mg, 15mg, 20mg
Pregnancy
Consult Doctor
Brands
Xarelto
Protein binding
92% to 95%
PubChem CID
6433119
MedlinePlus
a611049
ChEBI
68579
ATC code
B01AF01
DrugBank
DB06228
KEGG
D07086
Routes of administration
By mouth
Directions
The dosage of XARELTO (Rivaroxaban) depends on the condition being treated and how well the kidney is functioning. XARELTO (Rivaroxaban) should be prescribed at the following doses:
- Nonvalvular Atrial fibrillation: 20 mg once daily with food
- Treatment of DVT, PE, and reduction of recurrence: 15 mg twice daily with food for 21 days and then 20 mg once daily with food thereafter
- Prophylaxis of DVT following hip or knee surgery: 10 mg once daily with or without food
Doses 15 mg or higher should be taken with food to improve absorption. Doses below 15 mg can be taken with or without food.
If you have impaired kidney function, your doctor may prescribe a reduced dose.
Ingredients
The active ingredient in XARELTO (Rivaroxaban) is rivaroxaban.
Cautions
The use of XARELTO (Rivaroxaban) is not recommended in patients with prosthetic heart valves.
XARELTO has the potential to cause serious and fatal bleeding events, including gastrointestinal bleeds, intracranial hemorrhage, and other bleeding complications.
Do not discontinue XARELTO (Rivaroxaban) without speaking to your doctor first. Discontinuing the medication may cause an increased risk of clot formation.
Side Effects
The most common Xarelto Side Effects are bleeding events. These may include:
- Bruising
- Fatal bleeding
- Gastrointestinal bleed
- Hemorrhagic stroke
- Intracranial hemorrhage (ICH)
Speak with your doctor for a full list of adverse reactions related to XARELTO (Rivaroxaban) therapy.
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References
- Xarelto [package insert]. Titusville, NJ: Janssen Pharmaceuticals, 2011.
- Kearon C, Akl EA, Ornelas J, et al. “Antithrombotic Therapy for VTE Disease.” Chest. 2016;149(2):315-352. doi:10.1016/j.chest.2015.11.026
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9940
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