What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Xeljanz (Tofacitinib)

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Brand

Xeljanz (Tofacitinib)

Prescription Required

Strength

5mg

10mg

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  • Product Details

    Description

    What is Xeljanz?

    Xeljanz (tofacitinib) is a drug used to treat autoimmune disorders like psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis.

    How does it work?

    Xeljanz works by reducing your body’s ability to mount an immune response.

    How is it supplied?

    You can buy Xeljanz online as 5mg or 10mg tablets.  You can also get Xeljanz as 11mg or 22mg extended-release tablets.

    How should I store it?

    Store your Xeljanz at room temperature and keep it out of reach of children. 

    Directions

    Should I take Xeljanz with food?

    • You can take Xeljanz with or without food.

    Are there any special instructions?

    • Swallow your Xeljanz tablets whole. Do not crush or chew them.
    • To switch from immediate-release tablets to extended-release tablets:
      • Take your second immediate-release tablet of the day, then
      • Start your next day with an extended-release tablet

    What is the usual dose?

    • The usual dosages for Xeljanz are as follows:
      • Psoriatic Arthritis
        • Immediate-release tablets – Take 5mg by mouth twice daily
        • Extended-release tablets – Take 11mg by mouth once daily
      • Rheumatoid Arthritis
        • Immediate-release tablets – Take 5mg by mouth twice daily
        • Extended-release tablets – Take 11mg by mouth once daily
      • Ulcerative Colitis
        • Immediate-release tablets
          • Initial dose – Take 10mg by mouth twice daily for eight weeks, then transition to the maintenance dose. If your therapeutic response is not adequate after eight weeks, continue taking 10mg twice daily for another eight weeks. Stop taking Xeljanz if you do not achieve an adequate response after 16 weeks.
          • Maintenance dose – Take 5mg by mouth twice daily. Your doctor might periodically increase your dose to 10mg twice daily, depending on how well your therapy is going.
        • Extended-release tablets
          • Initial dose – Take 22mg by mouth once daily for eight weeks, then transition to the maintenance dose. If your therapeutic response is not adequate after eight weeks, continue taking 22mg daily for an additional eight weeks. Stop taking Xeljanz if you do not achieve an adequate response after 16 weeks.
          • Maintenance dose – Take 11mg once daily. Your doctor might periodically increase your dose to 22mg once daily, depending on how well your therapy is going.

    Ingredients

    What is the active ingredient in Xeljanz?

    • The active ingredient in Xeljanz is tofacitinib.

    What are the inactive ingredients?

    Cautions

    Who should avoid taking Xeljanz?

    • Do not take Xeljanz if you have a known allergy to any of the ingredients.
    • Avoid Xeljanz if you are at an increased risk of blood clots.

    What are the risks?

    • Xeljanz has a black box warning regarding serious infections, malignancy, and thrombosis. Review the full warning in the package insert and discuss your risks with your doctor.
    • You should not receive live vaccinations while using Xeljanz. Discuss alternative vaccine options with your doctor or pharmacist.
    • Xeljanz can increase your risk of skin cancer.
    • Xeljanz can increase your blood lipid levels.
    • Xeljanz can increase your risk of gastrointestinal perforation.
    • Xeljanz can increase your risk of infection.
    • Xeljanz can cause a decrease in your white blood cell count. Your doctor should monitor your blood before you start using Xeljanz and periodically while you are in treatment.
    • Xeljanz can damage your liver. Discuss your risk with your doctor.
    • Tell your doctor if you have a history of tuberculosis.
    • Tell your doctor if you have ever had hepatitis B. infection.
    • If you are being treated for rheumatoid arthritis, you could have an increased risk of pulmonary embolism. Discuss your risk with your physician.

    Side Effects

    What are the common side effects of Xeljanz?

    • Increased HDL and LDL levels
    • Headache
    • Urinary tract infection
    • Nasopharyngitis
    • Upper respiratory infection

    What are the serious side effects?

    • Skin cancer
    • Gastrointestinal perforation
    • Anemia
    • Decreased lymphocyte count
    • Deep vein thrombosis
    • Neutropenia
    • Thrombosis
    • Liver injury
    • Infectious disease
    • Lymphoproliferative disorder following transplantation
    • Opportunistic infection
    • Tuberculosis
    • Epstein Barr virus
    • Pulmonary embolism

    Other Considerations

    • Compare the Xeljanz cost at Canada Pharmacy to your local drug store.

    References:

    1. DailyMed - XELJANZ- tofacitinib TABLET, film coated xeljanz XR- tofacitinib tablet, extended release. (2020). Retrieved March 31, 2020
    2. Xeljanz. (n.d.). Retrieved March 31, 2020


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13253

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