Xpovio (Selinexor)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Xpovio is a medication prescribed for multiple myeloma management.
People with multiple myeloma have an excessive production of malignant plasma cells in the bone marrow.
Xpovio works by inhibiting the Exportin-1 (XPO1) protein vital for myeloma cell survival. Blocking XPO1 with Xpovio restricts malignant plasma cell growth.
Directions
Take Xpovio exactly as directed by your physician. Do not change the dosage or stop taking it without consulting your physician.
Ingredients
The active ingredient is selinexor.
Interactions
Common drug-drug interactions may include:
- Antithymocyte Globulin (Equine)
- Baricitinib
- BCG (Intravesical)
- BCG Products
- Brivudine
- Chloramphenicol (Ophthalmic)
- Cladribine
- CloZAPine
- COVID-19 Vaccine
- Deferiprone
- Dengue Tetravalent Vaccine (Live)
- Denosumab
- Desmopressin
- Deucravacitinib
- Dipyrone
- Fexinidazole
- Filgotinib
- Inebilizumab
- Influenza Virus Vaccines
- Leflunomide
- Mumps- Rubella- or Varicella-Containing Live Vaccines
- Nadofaragene Firadenovec
- Natalizumab
- Ocrelizumab
- Ofatumumab
- Olaparib
- Pidotimod
- Pimecrolimus
- Pneumococcal Vaccines
- Poliovirus Vaccine (Live/Trivalent/Oral)
- Polymethylmethacrylate
- Promazine
- Rabies Vaccine
- Ritlecitinib
- Ropeginterferon Alfa-2b
- Ruxolitinib (Topical)
- Sipuleucel-T
- Sphingosine 1-Phosphate (S1P) Receptor Modulator
- Tacrolimus (Topical)
- Talimogene Laherparepvec
- Tertomotide
- Tofacitinib
- Typhoid Vaccine
- Ublituximab
- Upadacitinib
- Vaccines (Inactivated/Non-Replicating)
- Vaccines (Live)
- Yellow Fever Vaccine
Cautions
Before starting Xpovio treatment, speak with your doctor about your medical history, including renal, hepatic, or bone marrow disorders.
Your doctor should perform regular monitoring to assess the therapeutic response.
Side Effects
Common adverse reactions include:
- Abdominal pain
- Anemia
- Anorexia
- Asthenia
- Blurred vision
- Cardiac failure
- Cataract
- Constipation
- Cough
- Decreased appetite
- Decreased serum albumin
- Decreased serum calcium
- Decreased serum magnesium
- Decreased serum phosphate
- Dehydration
- Diarrhea
- Dizziness
- Dysgeusia
- Dyspnea
- Edema
- Epistaxis
- Falling
- Fatigue
- Febrile neutropenia
- Fever
- Headache
- Hemorrhage
- Herpes virus infection
- Hyperglycemia
- Hypokalemia
- Hyponatremia
- Hypotension
- Increased creatinine phosphokinase in blood specimen
- Increased serum alanine aminotransferase
- Increased serum aspartate aminotransferase
- Increased serum bilirubin
- Increased serum creatinine
- Increased serum potassium
- Infection
- Insomnia
- Leukopenia
- Lymphocytopenia
- Mental status changes
- Musculoskeletal pain
- Nausea
- Neurological signs and symptoms
- Neutropenia
- Peripheral sensory neuropathy
- Pneumonia
- Sepsis
- Syncope
- Thrombocytopenia
- Upper respiratory tract infection
- Urinary tract infection
- Vomiting
- Weight loss
References
Xpovio [package insert]. City, ST: Pharma; year.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13773
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