What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Zortress (Everolimus)

Also Known as Certican


Zortress (Everolimus)

Prescription Required


You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

Generic Equivalent - Zortress (Everolimus)

Prescription Required


You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details


    Zortress (everolimus) is a prescription medication used to prevent organ rejection in adults who had a kidney or liver transplant.

    Zortress is available in 0.25 mg, 0.5 mg, 0.75 mg, and 1 mg oral tablets.

    Fact Table




    US DailyMed, US FDA, EU EMA


    Everolimus is well absorbed orally, with a bioavailability of approximately 30% to 40%

    Legal status


    Chemical Name


    Elimination half-life

    The elimination half-life of everolimus ranges from approximately 30 to 60 hours.

    Dosage (Strength)

    0.25 mg to 1 mg


    Consult Doctor


    Zortress is one of the brand names for everolimus. It may also be sold under other brand names, such as Afinitor

    Protein binding

    Everolimus is highly bound to plasma proteins, with approximately 74% to 77% protein binding

    PubChem CID






    ATC code






    Routes of administration

    By Mouth


    Take Zortress exactly as your doctor has instructed. If you have any questions or concerns, contact your doctor or pharmacy.

    Recommended Starting Dose

    Kidney Transplantation: 0.75 mg by mouth two times a day. Start as soon as possible after transplantation.

    Liver Transplantation: 1 mg by mouth two times a day. Start 30 days after transplantation.

    Dosing may be adjusted in patients with liver function problems.


    The active ingredient in Zortress is everolimus. Inactive ingredients include butylated hydroxytoluene, magnesium stearate, lactose monohydrate, hypromellose, crospovidone, and lactose anhydrous.


    Do not take Zortress if you are allergic to everolimus, sirolimus, or to any of the other ingredients contained in the medication.


    Zortress has the following FDA Boxed Warning:

    • Zortress should only be prescribed by physicians who have experience in immunosuppressive therapy and transplant management
    • Zortress can cause immunosuppression, which can increase the risk of infection and malignancies
    • Kidney graft thrombosis may occur more frequently
    • When taking cyclosporine with Zortress, the dose of cyclosporine should be decreased to reduce kidney problems
    • Use of Zortress in heart transplantation is not recommended, as there has been increased mortality in a clinical trial
    • Before you begin treatment with Zortress, inform your doctor of:
      • All the medications you take
      • Your allergies
      • Your current health conditions and past medical history
      • Your pregnancy or breastfeeding status
    • Zortress may cause angioedema, or swelling underneath the skin. Taking Zortress with other medications that can cause angioedema, including certain blood pressure medications like angiotensin converting enzyme (ACE) inhibitors, can increase the risk for angioedema.
    • Wounds may take longer to heal and wound-related complications may occur more frequently while taking Zortress.
    • Interstitial lung disease has occurred in patients taking Zortress.
    • Cholesterol and triglyceride levels may increase while taking Zortress.
    • Protein may be present in the urine during treatment with Zortress.
    • Zortress may increase the risk for opportunistic infections such as polyoma virus infections.
    • Taking Zortress with cyclosporine may increase the risk of thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS).
    • Zortress may increase the risk of diabetes after transplant. Blood sugar levels should be closely monitored.
    • Zortress may cause harm to an unborn baby; therefore, women should be advised to use effective birth control methods during treatment and for 8 weeks after taking the last dose.
    • Zortress may cause male infertility.
    • Patients should not receive live vaccines while taking Zortress.
    • Patients should not consume grapefruit or grapefruit juice while taking Zortress with cyclosporine or tacrolimus.
    • Patients should avoid taking Zortress if they have rare hereditary disorders of galactose intolerance such as Lapp lactase deficiency or glucose-galactose malabsorption.

    Side Effects

    Zortress can cause side effects, including swelling, constipation, high blood pressure, nausea, anemia, urinary tract infection, elevated lipid levels, diarrhea, headache, fever, stomach pain, low white blood cell count, and high cholesterol levels. Other side effects may also occur, so be sure to contact your doctor right away if you experience side effects that bother you or won’t go away.

    With a valid prescription from your doctor, you can buy Zortress online at a competitive price from Canada Pharmacy.


    Zortress. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2021.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 12966

  • Product Reviews


Please wait while the page is loading. Do not hit refresh or the browser back button to avoid any loss of information.

If you have any questions or concerns, please contact our Customer Service team via the chat option on our website or calling us toll free at: 1-800-891-0844