Adlyxin (Lixisenatide)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Adlyxin (Lixisenatide) is an injectable medication used to treat type 2 diabetes in adults. It is part of a class of drugs called GLP-1 receptor agonists, which stimulate insulin production in the pancreas and slow gastric emptying. Adlyxin helps manage blood sugar levels, especially when used along with a healthy diet and regular exercise.
Fact Table
Formula
C215H347N61O65S
License
US DailyMed, EU EMA
Bioavailability
approximately 2.17%
Legal status
Rx-only
Chemical Name
Lixisenatide
Elimination half-life
3-4 hours
Dosage (Strength)
10 mcg, 20 mcg
Pregnancy
Not recommended for use during pregnancy
Brands
Adlyxin
Protein binding
approximately 55%
PubChem CID
90472060
MedlinePlus
a617005
ChEBI
85662
ATC code
A10BJ03
DrugBank
DB09265
KEGG
D09729
Routes of administration
Subcutaneous
Directions
Typically, Adlyxin is administered as a 10 mcg injection once daily for the first 14 days. Then, the dosage is increased to 20 mcg once daily. The medication is recommended to be taken within one hour before the first meal of the day. It can be injected under the skin (subcutaneous) of the upper arm, thigh, or stomach area. Follow the dosage guidelines prescribed by your healthcare provider, as individual needs may vary.
Ingredients
The main active ingredient in Adlyxin is lixisenatide. In addition to lixisenatide, Adlyxin may contain other inactive ingredients that help with formulation and stability.
Contraindications
Avoid using Adlyxin if you have a history of severe allergic reactions to lixisenatide or any ingredients of the medication.
Cautions
- Before taking Adlyxin, it is important to inform your doctor about:
- Any medications you take, especially antidiabetic drugs, contraceptives, antibiotics, or other drugs that might interact with Adlyxin.
- Any medical conditions you have, including pancreatitis, gallbladder or kidney problems, or history of allergic reactions to medications.
- If you are pregnant or plan to become pregnant, Adlyxin may cause harm to the unborn baby.
- If you are breastfeeding or plan to breastfeed, Adlyxin might pass into breast milk and cause harm to the baby.
- Frequent medical check-ups while taking Adlyxin may be necessary to monitor blood sugar levels and the state of your kidneys and gallbladder.
- If you're on medications such as sulfonylurea or insulin, using Adlyxin could increase the risk of experiencing hypoglycemia, characterized by symptoms like headache and dizziness. A healthcare provider may modify the dosages of your other medications to reduce the risk.
- If you already have kidney problems, Adlyxin's side effects like diarrhea or nausea may worsen your condition by causing dehydration.
- Some individuals have encountered gallbladder complications when using Adlyxin. Warning signs include abdominal pain and fever, which may warrant immediate medical intervention.
- The Adlyxin pen should never be used by multiple people, even with a needle change, to avoid cross-contamination.
- The formation of antibodies to lixisenatide, the active ingredient in Adlyxin, has been observed in some cases. This can affect the control of blood sugar levels, potentially requiring a switch to alternative diabetes treatments.
Side Effects
Although Adlyxin can be an effective treatment, there are some potential side effects that users should be aware of. The most common side effects of Adlyxin include gastrointestinal problems like nausea, vomiting, and diarrhea. Some people may also experience headache, dizziness, and hypoglycemia as a result of using Adlyxin.
Some side effects of Lixisenatide may go away during treatment as the body adjusts to the medicine. Healthcare professionals may be able to offer advice on preventing or reducing some of these side effects.
In some cases, severe side effects may occur, such as an allergic reaction, kidney failure, and or gallbladder problems. Seek immediate medical attention if you experience serious side effects such as hives, difficulty breathing, severe rash, rapid heartbeat, trouble swallowing, or swelling of the face, lips, tongue, or throat.
References:
- Adlyxin Prescribing Information. Bridgewater, NJ: Sanofi-Aventis; 2022.
- Lixisenatide Injection Drugs, Herbs and Supplements. Bethesda, MD: National Library of Medicine; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13813
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