Cetrotide (Cetrorelix)
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Product Details
Description
Cetrotide (Cetrorelix) works as a synthetic decapeptide and is identified as a gonadotropin-releasing hormone (GnRH) antagonist. It may help in preventing premature luteinizing hormone (LH) surges in women who are undergoing controlled ovarian stimulation during fertility treatments. Clinically, Cetrotide is an injectable medication that is utilized alongside other hormones in in-vitro fertilization (IVF) cycles to delay ovulation, which helps improve the chances of successful fertilization and pregnancy.
Directions
Cetrotide is usually self-administered through a subcutaneous injection — an injection under the skin. Typically, the dosage is 0.25 mg and may be given once daily during the early to mid-follicular phase of the menstrual cycle. Treatment commonly begins on day 5 or 6 of the cycle, and it's continued until the day hCG administration takes place.
Before injecting, wash your hands well and prepare the injection site as advised by your healthcare provider. Use the provided needles and pre-filled syringe for the injection. It's crucial to follow the specific instructions provided with your medication kit to ensure the correct technique for both mixing the medication and administering the injection. When injecting Cetrotide, rotate the injection sites as directed to reduce the likelihood of skin irritation.
Ingredients
The active ingredient in a Cetrotide injection is Cetrorelix. In addition to the active component, Cetrotide includes mannitol, a type of sugar alcohol which serves as a stabilizer, and sterile water that is mixed with the powdered form to prepare the injectable solution.
Contraindications
Avoid using Cetrotide if any of the following apply:
- Known hypersensitivity to Cetrorelix or any of the excipients in the formulation.
- Allergic reactions to extrinsic peptide hormones or mannitol.
- Pregnancy, due to potential harm to the fetus.
- Severe kidney impairment, as this condition might affect the drug's efficacy and safety profile.
Cautions
- Before using Cetrotide, inform your healthcare provider about the following:
- Any existing health conditions
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- Cetrotide should only be prescribed by doctors who have experience in fertility treatments. Before beginning treatment with Cetrotide, it’s crucial to ensure that you are not already pregnant.
- There have been reports of severe allergic reactions to Cetrotide, even with the first dose. Symptoms can include a severe, life-threatening reaction that may involve coughing, a rash, and a sudden drop in blood pressure. These reactions are rare but serious.
Side Effects
Cetrotide side effects commonly include mild reactions at the injection site, such as redness, itching, and swelling. Other typical side effects include nausea and headaches. These reactions are usually mild, brief, and manageable.
While rare, Cetrotide can lead to more serious conditions. Ovarian Hyperstimulation Syndrome (OHSS), a potentially serious complication from fertility treatments, was reported in some women, characterized by moderate to severe symptoms. Additionally, there have been reports of hypersensitivity reactions, including severe allergic responses. During clinical trials, some cases of congenital anomalies were noted in newborns of mothers who used Cetrotide, such as heart defects and other developmental issues. It’s important for patients to be aware of these risks and discuss any concerns with their healthcare provider, especially if planning to become pregnant or during early pregnancy stages.
References:
- Cetrotide (Cetrorelix) Product Monograph. Rockland, MA: EMD Serono; 2023.
- Cetrotide (Cetrorelix) Drug Label Information. Rockland, MA: EMD Serono; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10229
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