Description
Clavacillin (amoxicillin and clavulanate potassium) is a prescription antibiotic used to treat bacterial infections in dogs and cats. It treats skin and soft tissue infections such as wounds, abscesses, and cellulitis in both dogs and cats, as well as gum (periodontal) infections in dogs and urinary tract infections in cats. Amoxicillin kills bacteria by stopping them from building their cell walls, while clavulanate potassium blocks the enzyme some bacteria use to resist antibiotics. Therefore, the combination works against a wider range of bacteria than amoxicillin alone.
Directions
Give Clavacillin exactly as prescribed by a veterinarian. For dogs, the usual dose is
6.25 mg per pound of body weight twice daily. For cats, the usual dose is
62.5 mg twice daily, equal to one 62.5 mg tablet, regardless of body weight.
Skin and soft tissue infections are usually treated for 5 to 7 days. Deep pyoderma in dogs may require up to 21 days of treatment, while urinary tract infections in cats may require 10 to 14 days or longer. Treatment should not continue for more than 30 days.
If there is no improvement after 5 days of treatment in dogs or 3 days in cats, contact a veterinarian to have the treatment reevaluated.
Keep the tablets in the foil strip until they are ready to use. Store them in a secure location out of reach of dogs, cats, and other animals.
Ingredients
The active ingredients in Clavacillin are amoxicillin trihydrate and clavulanate potassium.
Cautions
Before using this medication, you may want to consult a veterinarian about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
Clavacillin is for use in dogs and cats only. Its safety in pregnant or breeding animals has not been determined.
The 62.5 mg tablets may be used in dogs and cats, while the higher strengths—125 mg, 250 mg, and 375 mg—are for use in dogs only.
Keep this and all medications out of reach of children and pets.
Contraindications
Avoid giving this medication if the animal has a history of an allergic reaction to any penicillins or cephalosporins.
Side Effects
Common side effects of Clavacillin may include:
- Loss of appetite
- Tiredness or low energy
- Vomiting
- Diarrhea
Because Clavacillin contains a penicillin antibiotic called amoxicillin, it may cause allergic reactions in some animals. Contact a veterinarian immediately if the pet develops signs of an allergic reaction, such as facial swelling, hives, or trouble breathing, as emergency treatment may be needed.
References
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Clavacillin Drug Label Information. Overland Park, KS: Dechra Veterinary Products, LLC; 2026.
Frequently Asked Questions about Clavacillin
What is Clavacillin?
Clavacillin is a prescription veterinary antibiotic containing amoxicillin and clavulanate potassium. Amoxicillin kills susceptible bacteria, while clavulanate helps protect amoxicillin from certain bacterial resistance enzymes.
What is Clavacillin used for?
Clavacillin is used in dogs and cats to treat susceptible bacterial infections. Common uses include wounds, abscesses, cellulitis, skin and soft-tissue infections, periodontal infections in dogs, and certain urinary tract infections in cats.
Does Clavacillin treat viral infections?
No. Clavacillin works only against susceptible bacteria and does not treat viruses, fungal infections, or parasites. Unnecessary antibiotic use may contribute to bacterial resistance.
How is Clavacillin given?
Clavacillin is given by mouth as tablets or liquid drops, depending on the prescribed product. The dose is based on the animal’s weight, infection, formulation, and response to treatment.
Should Clavacillin be given with food?
Clavacillin may generally be given with a small amount of food to reduce stomach upset. Make sure the pet consumes the entire prescribed dose.
What are the common side effects of Clavacillin?
Possible side effects include vomiting, diarrhea, reduced appetite, and lethargy. Contact the veterinarian if these effects are severe, persistent, or accompanied by dehydration or blood in the stool.
Can Clavacillin cause an allergic reaction?
Yes. Pets allergic to penicillins or cephalosporins should not receive Clavacillin. Facial swelling, hives, breathing difficulty, collapse, or sudden severe vomiting requires immediate veterinary attention.
What should be done if a dose is missed?
Give the missed dose when remembered unless it is almost time for the next scheduled dose. Do not give two doses together unless specifically instructed by the veterinarian.
How should Clavacillin be stored?
Tablets should be stored at controlled room temperature in a dry location. Reconstituted Clavacillin Drops should be refrigerated, shaken before each dose, and discarded after the period stated on the label, commonly 10 days.
Can Clavacillin be stopped when the pet improves?
Continue treatment for the full period prescribed unless the veterinarian directs otherwise. Stopping early may allow the infection to return and may contribute to antibiotic resistance.
About Dr. Gerardo Sison (Page Author)
Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13664