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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Epiduo Gel

Brand

Epiduo Gel

Prescription Required

Strength
Qty
0.3% / 2.5% Forte 45grams Pump
0.1% / 2.5% 30g

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  • Product Details

    Description

    Epiduo Gel combines Adapalene and Benzoyl Peroxide. It is used as a medication to treat acne vulgaris. Adapalene falls into the category of synthetic retinoids, influencing cell turnover and reducing inflammation, while Benzoyl Peroxide may help kill bacteria and clear pores. This gel is suitable for topical application and is typically prescribed for individuals nine years of age and older. When used as directed, Epiduo Gel may help alleviate the symptoms of acne, but its full effectiveness can vary among individuals.

    Fact Table

    Formula

    C28H28O3 (Adapalene), C14H10O4 (Benzoyl peroxide)

    License

    US FDA, EMA

    Bioavailability

    Adapalene: ~0.25% (topical); Benzoyl peroxide: minimal systemic absorption

    Legal status

    Prescription only (Rx)

    Chemical Name

    Adapalene / Benzoyl peroxide

    Elimination half-life

    Adapalene: ~20 hours (topical); Benzoyl peroxide: rapidly metabolized to benzoic acid

    Dosage (Strength)

    0.1% Adapalene / 2.5% Benzoyl peroxide (gel)

    Pregnancy

    Use with caution; limited human data

    Brands

    Epiduo, Epiduo Forte (0.3% adapalene)

    Protein binding

    Adapalene: ~95–97%; Benzoyl peroxide: negligible

    PubChem CID

    Adapalene: 60164, Benzoyl peroxide: 7186

    MedlinePlus

    a601087

    ChEBI

    Adapalene: 31186, Benzoyl peroxide: 3094

    ATC code

    D10AD53

    DrugBank

    Adapalene: DB00210, Benzoyl peroxide: DB00456

    KEGG

    Adapalene: D02521, Benzoyl peroxide: D07578

    Routes of administration

    Topical (gel)

    Directions

    The standard Epiduo Gel dosage involves applying the medication to the affected area once a day, ensuring the skin is clean and dry before application. It is crucial to use only a thin layer to cover the acne-prone regions, avoiding the eyes, lips, and nose. While using Epiduo Gel, patients should limit exposure to sunlight and artificial UV rays, such as tanning beds, and apply sunscreen when outdoors, as the treatment may increase the skin's sensitivity to sunlight.

    Ingredients

    Epiduo Gel contains a blend of Adapalene 0.1% and Benzoyl Peroxide 2.5%, which works together to reduce acne.

    Contraindications

    There are no listed contraindications on the drug label. However, if you have a history of hypersensitivity to Adapalene, Benzoyl Peroxide, or any component of the formulation, avoid its use.

    Cautions

    • Before starting treatment with Epiduo Gel, be sure to inform your healthcare provider about the following:
      • Any medical conditions you currently have
      • Any allergies
      • All medications you are currently taking
      • Whether you are pregnant or breastfeeding
    • Minimize exposure to sunlight and sunlamps while using Epiduo gel. Wear sunscreen and protective clothing like hats when exposure cannot be avoided.
    • Avoid using Epiduo gel in extreme weather conditions like wind or cold as these may irritate the skin.
    • Common skin reactions include redness, scaling, dryness, and stinging or burning, especially in the first four weeks. These usually become less intense with continued use.
    • If skin irritation becomes severe, consider using a moisturizer, applying Epiduo gel less frequently, or stopping its use.
    • Do not apply Epiduo gel on cuts, abrasions, eczematous skin, or sunburned areas.
    • Avoid waxing as a hair removal method on areas treated with Epiduo gel.
    • Avoid using other skin products that are irritating, such as those containing high levels of alcohol, astringents, or spices, alongside Epiduo gel.

    Side Effects

    The most reported side effects of Epiduo Gel involve skin reactions. These include dryness, where 7% of users experienced this issue, compared to 2% using a non-medicated gel. Other reactions such as contact dermatitis, skin irritation at the application site, and burning sensations were reported, affecting a small percentage of users. Skin irritation generally peaks in the first week of use and tends to decrease over time.

    Rare but more severe reactions have also been reported with Epiduo Gel use. These include eyelid swelling, severe sunburn, skin blisters, intense itching, facial swelling, conjunctivitis, noticeable skin discoloration, and eczema. Symptoms like throat tightness and allergic contact dermatitis have been noted as well, indicating possible allergic reactions. Patients should seek immediate medical attention if experiencing significant discomfort or signs of an allergic reaction.

    References:

    1. Epiduo Gel Product Monograph. Fort Worth, Texas: GALDERMA LABORATORIES, L.P.; 2013.
    2. Epiduo Gel Drug Label Information. Fort Worth, Texas: GALDERMA LABORATORIES, L.P.; 2018.


    Dr Gerardo Sison
    About Dr. Gerardo Sison (Page Author)


    Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10239

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