What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Esbriet (Pirfenidone)
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Product Details
Description
Esbriet (Pirfenidone) is a medication used to treat idiopathic pulmonary fibrosis (IPF). It belongs to a class of drugs called pyridones and works by reducing the production of certain substances in the body that contribute to lung scarring. Patients looking to buy Esbriet medication should be aware that it is available by prescription only, and the Esbriet cost may vary depending on the pharmacy and insurance coverage.
Fact Table
Formula
C12H11NO
License
US DailyMed, EU EMA
Bioavailability
46%
Legal status
Rx-only
Chemical Name
Pirfenidone
Elimination half-life
2.4 hours
Dosage (Strength)
200mg, 267mg, 600mg, 801mg
Pregnancy
Consult Doctor
Brands
Esbriet
Protein binding
50–58%
PubChem CID
40632
MedlinePlus
a615008
ChEBI
32016
ATC code
L04AX05
DrugBank
Not Available
KEGG
D01583
Routes of administration
Oral
Directions
The standard dosage of Esbriet is three capsules (or a total of 801 mg) three times daily. Each dose should be taken with food at consistent times each day, such as in the morning, afternoon, and evening. Maintaining this schedule can help maintain stable levels of the medication in the body and support its effectiveness. Always follow your doctor's instructions when using Esbriet to manage idiopathic pulmonary fibrosis.
Ingredients
The primary ingredient in Esbriet ispirfenidone.
Contraindications
There are no labeled contraindications on the drug label. However, the drug may need to be avoided in individuals with severe liver disease or end-stage kidney stage.
Cautions
- Before starting Esbriet, it's important to inform your doctor about:
- Any medications you take, especially those that may interact with Esbriet, such as certain antibiotics
- Existing medical conditions, particularly liver problems, as Esbriet can affect liver function
- If you are pregnant, breastfeeding, or planning to do either, as this drug may not be appropriate
- The use of Esbriet may cause an increase in liver enzymes. The dosage may need to be reduced or discontinued in some cases of liver enzyme changes.
- Esbriet may cause increased sensitivity to sunlight, requiring protective clothing and sunscreen usage.
- Esbriet may cause gastrointestinal problems, such as nausea, vomiting, or diarrhea.
- Regular monitoring for negative side effects may be needed in order to evaluate whether dosage adjustments or discontinuation of Esbriate is required.
- People who smoke may experience reduced exposure to Esbriet, possibly affecting the drug's effectiveness.
Side Effects
Like all medications, Esbriet may have some side effects. The most common side effects include nausea, vomiting, diarrhea, indigestion, heartburn, and stomach pain. Other common side effects are dizziness, fatigue, gastroesophageal reflux disease, skin rash, upper abdominal pain, weight loss, and decreased appetite.
There are potentially severe side effects associated with Esbriet, such as severe skin reactions like skin blisters, rash, sores in the mouth, or other severe skin symptoms. Report any severe side effects to a healthcare professional immediately.
References:
- Esbriet Prescribing Information. Brisbane, CA: InterMune, Inc.; 2023.
- Esbriet Safety Information. Genentech. Accessed August 9, 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13792
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