Floxin (Ofloxacin)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Floxin, known by the generic name Ofloxacin, is a fluoroquinolone antibiotic used to treat bacterial infections in the body. It fights bacteria by interfering with their DNA replication process, effectively stopping their growth and spread. Clinicians prescribe Floxin to treat various infections, such as bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and prostatitis.

    F act Table

    Formula

    C18H20FN3O4

    License

    US FDA (1990)

    Bioavailability

    98% (oral)

    Legal status

    Prescription only (?)

    Chemical Name

    (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

    Elimination half-life

    9 hours

    Dosage (Strength)

    200 mg, 300 mg, 400 mg tablets; 0.3% ophthalmic solution

    Pregnancy

    Consult a doctor (Category C)

    Brands

    Floxin, Ocuflox

    Protein binding

    32%

    PubChem CID

    4583

    MedlinePlus

    a688010

    ChEBI

    CHEBI:7731

    ATC code

    J01MA01

    DrugBank

    DB01165

    KEGG

    D00315

    Routes of administration

    Oral, Ophthalmic, Intravenous (IV)

    Directions

    Floxin comes in different forms, including oral tablets and ear drops. The medication should be taken as prescribed for a healthcare provider. The usual dosage and dosage form for bacterial infections varies depending on the severity and type of infection. For example, the oral tablet is usually taken twice daily, and it’s best taken on an empty stomach, one hour before or two hours after meals. Always consult a healthcare provider for the appropriate dosage.

    Ingredients

    The active ingredient in Floxin is Ofloxacin. The medication may also contain inactive ingredients, such as hydroxypropyl cellulose, hypromellose, and magnesium stearate.

    Contraindications

    Floxin should not be taken if you have a hypersensitivity or allergy to Ofloxacin or other fluoroquinolones, such as Ciprofloxacin.

    Cautions

    • Speak with a healthcare provider about the following before taking Floxin:
      • Any medications you are currently taking
      • If you are pregnant or breastfeeding
      • Any allergies you may have
      • Any other medical conditions you have
    • Floxin can increase the risk of tendon problems, such as tendinitis or even tendon rupture, which might require surgery. This risk is higher in people over 60, those on steroid medication, and patients with kidney, heart, or lung transplants.
    • Floxin isn't recommended for treating infections in the urethra, vagina, cervix, rectum, or anus due to its potent nature and the sensitivity of these areas.
    • Your doctor will check your liver function with blood tests before and during treatment because Floxin can affect your liver.
    • Look out for new or worsening lung symptoms like trouble breathing, as Floxin can cause lung issues. Your treatment might need to be adjusted if this happens.
    • Don't start Floxin if your blood pressure isn't controlled. Your blood pressure will be monitored closely once you begin treatment.
    • Floxin can affect your heart's rhythm, especially if you're at risk for heart rhythm issues. Your doctor will keep a close watch on this.
    • Minimize or avoid exposure to sunlight or UV light, as Floxin can make your skin more sensitive to the sun.
    • If you have a condition like myasthenia gravis that causes muscle weakness, Floxin might make it worse. It's usually advised to avoid this medication in such cases.
    • Floxin can cause effects like seizures, tremors, or confusion. It's used cautiously in patients with conditions that predispose them to seizures.
    • Serious allergic reactions can happen, sometimes after the first dose. If you experience symptoms like hives, difficulty breathing, or swelling, stop Floxin and seek medical help immediately.

    Side Effects

    Floxin antibiotic side effects include nausea, insomnia, headaches, dizziness, diarrhea, vomiting, rash, itching, and various genital irritations. Despite the majority of these side effects being mild to moderate, they can greatly impact daily activities and overall well-being.

    Floxin carries a risk of serious adverse effects, especially tendinitis and tendon rupture, which are more likely to occur in patients over 60, those on corticosteroids, and patients with kidney, heart, or lung transplants. It may worsen muscle weakness in individuals with myasthenia gravis and should be avoided in patients with this condition. The drug is also associated with central nervous system effects, including seizures and toxic psychosis, and may cause severe hypersensitivity reactions, nerve pain, and Clostridium difficile-associated diarrhea (CDAD). Patients experiencing symptoms of serious side effects should discontinue the medication immediately and seek medical attention.

    References:

    1. Floxin (Ofloxacin) Product Monograph. Raritan, NJ: Ortho-McNeil-JanssenPharmaceuticals; 2011.
    2. Floxin (Ofloxacin) Product Monograph. Montvale, NJ: Daiichi Pharmaceutical Corporation; 2005.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1533

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