Genotropin (Somatropin)

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  • Product Details


    Genotropin, also known as somatropin, is a recombinant polypeptide hormone that matches the amino acid sequence of natural human growth hormone. Produced through recombinant DNA technology, Genotropin stimulates growth and cell reproduction in the body. Classified as a growth hormone, it's usually prescribed to treat growth failure in children and adults who lack natural growth hormone. It may also be used for patients with certain conditions like Prader-Willi syndrome and Turner syndrome, as well as for those who were short at birth and have not caught up in growth by a certain age.


    When using a Genotropin pen device, patients should follow their healthcare professional's instructions closely. This medication is typically injected under the skin (subcutaneously); rotating the injection site daily is necessary to prevent tissue breakdown. Dosage and schedule vary based on individual needs, weight, age, and condition. Patients or caregivers receive training to measure doses accurately using the Genotropin pen, which entails setting the correct dosage on the device and ensuring the medicine is at room temperature before administration. Keeping track of injections with tools like a calendar may help maintain a consistent treatment regimen.


    Genotropin contains several key ingredients, with the primary active ingredient being somatropin. Inactive ingredients may include:

    • Glycine: An amino acid that serves as a stabilizer
    • Mannitol: A sugar alcohol that acts as a tonicity agent
    • Sodium dihydrogen phosphate anhydrous: A buffering agent
    • Disodium phosphate anhydrous: Another buffering agent to maintain pH


    Avoid taking or using this medication if any of the following apply:

    • Known allergy to somatropin or any of its ingredients: This could lead to severe reactions.
    • Presence of active malignancy: Growth hormones may stimulate the growth of tumors.
    • Complications following open-heart or abdominal surgery, multiple accidental trauma, or acute respiratory failure: The risks increase under these conditions.
    • Prader-Willi syndrome patients who are severely obese or have severe breathing problems: Treatment should be avoided due to potential fatal complications.


    • Consult a healthcare provider about any of the following before starting treatment:
    • Allergies to any substances
    • All medications you’re taking
    • Other medical conditions you have
    • If you’re pregnant or breastfeeding
    • For patients recovering from serious illnesses, the benefits of continuing Genotropin should be carefully weighed against the potential risks.
    • Before starting treatment, children with Prader-Willi syndrome should be evaluated for upper airway obstruction and sleep apnea. Treatment should be discontinued if these issues arise.
    • Patients with pre-existing tumors should be monitored for tumor progression or recurrence. There's an increased risk of developing a second tumor, especially meningiomas in those who received radiation to the head for their first tumor.
    • Genotropin may unmask diabetes mellitus or impair glucose tolerance. Regular monitoring of glucose levels is advised, and doses of diabetes medications may need adjustment.
    • Before starting Genotropin, check for pre-existing papilledema, which may present as blurred vision or other vision problems. High blood pressure in the brain may develop but is typically reversible with discontinuation or dose reduction.
    • Serious allergic reactions to Genotropin can occur. Seek immediate medical attention if you experience an allergic reaction.
    • Symptoms like swelling in the arms or legs, joint pain, and carpal tunnel syndrome may frequently occur, especially in adults. Dose adjustments may be necessary.
    • Watch for symptoms that could signal your body's cortisol (a stress hormone) levels are too low. If you notice such changes and you have a condition where your adrenal glands don't produce enough hormones (adrenal insufficiency), your doctor may need to adjust your medication.
    • Genotropin could affect how your thyroid works, potentially showing or worsening underactive thyroid. It's advisable to regularly check your thyroid levels.
    • Children might experience slipped capital femoral epiphysis, showing as a limp or pain in the hip or knee. If your child shows these signs, get them checked promptly.
    • For children with scoliosis, keep an eye out for any increase in the spine's curve.
    • If you experience intense abdominal pain, it could be a sign of pancreatitis. Seek medical help if the symptoms persist.

    Side Effects

    Genotropin side effects mainly include fluid retention symptoms in adults with growth hormone deficiency, including swelling in the limbs, joint pain, stiffness, muscle pain, tingling, and reduced touch sensation. These effects are generally mild to moderate, occurring early in therapy and often temporary or improved with dosage adjustments.

    Genotropin may lead to serious health issues, including increased risk of tumors, worsened diabetes or sugar levels, high pressure in the brain, severe allergic reactions, and problems with bones and growth in children. For those with certain conditions like Prader-Willi syndrome, it's important to watch for breathing problems. Regular checks for changes in vision, sugar levels, and thyroid function are recommended. If you notice sudden pain in the hip or knee, swelling, or any allergic reactions, it's crucial to get medical help right away.


    1. Genotropin (Somatropin) Product Monograph. Belgium NV, Rijksweg: Pfizer; 2016.
    2. Genotropin (Somatropin) Drug Label Information. Belgium NV, Rijksweg: Pfizer; 2023.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9488

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