Description
Gravol contains an antihistamine classified as an H1 receptor antagonist. It contains Dimenhydrinate, which helps manage nausea, vomiting, and dizziness related to motion sickness, vertigo, or other medical conditions. This injectable drug works by blocking histamine and reducing stimulation in the brain areas that control nausea and vomiting. Healthcare providers may prescribe Gravol when oral medications aren’t the best option or when fast symptom relief is needed.
Directions
Gravol Injection 50 mg/mL can be given as a shot into the muscle or, after mixing with saline, slowly into a vein. For adults, typical doses are 25 to 50 mg every 4 to 6 hours as needed, with a maximum of 400 mg in one day; sometimes up to 100 mg may be used at a time if drowsiness isn’t a problem. For children, the amount depends on age: ages 2–5 get 12.5 to 25 mg every 6 to 8 hours (up to 75 mg per day), ages 6–11 get 25 to 50 mg every 6 to 8 hours (up to 150 mg per day), and ages 12–17 get 25 to 100 mg every 4 to 6 hours (up to 300 mg per day). Always follow a healthcare provider’s instructions while using this medication.
Ingredients
Dimenhydrinate is the active ingredient in Gravol.
Contraindications
Avoid taking or using this medication if any of the following apply:
- You are allergic to any ingredients in the medication or its packaging
- You are currently taking, or have taken within the past two weeks, a monoamine oxidase inhibitor (MAOI)
- You have narrow-angle glaucoma
- You have chronic lung disease
- You have an enlarged prostate (prostatic hypertrophy)
- You are under 2 years old
Cautions
- Before taking Gravol, consult a healthcare provider about the following:
- Any existing health conditions
- Any allergies
- A list of all medications you are currently taking
- Whether you are pregnant or breastfeeding
- Gravol is only for use in the muscle unless a doctor tells you otherwise. If it needs to be given by IV, it should be diluted to avoid serious heart problems linked to an ingredient called propylene glycol.
- Gravol can increase pressure in the eyes and worsen certain conditions like glaucoma or an enlarged prostate. It should also be used carefully in people with liver disease, asthma, or heart problems.
- Gravol may make mental health or seizure conditions worse, especially in people with a history of those issues. It should also be used carefully in people with trouble urinating or stomach blockages.
- In rare cases, serious skin reactions like Stevens-Johnson syndrome have been reported. Stop using Gravol and get medical help right away if you develop a skin rash while using it.
- Pregnant women should only use Gravol if the benefits clearly outweigh the risks. Small amounts may pass into breast milk, so nursing mothers should check with a doctor before using it.
- Gravol can cause complications during labor and delivery and may increase contractions. Doctors will weigh the risks and benefits in these situations.
- Older adults may be more sensitive to side effects like confusion, drowsiness, and difficulty urinating. These effects could raise the risk of falls or worsen conditions like dementia.
- Gravol is not recommended for children under 2 years old. In young children, especially under age 6, overdose or even regular doses can cause agitation, hallucinations, or seizures.
- Stop using Gravol and call your healthcare provider if a child shows signs of unusual excitement, confusion, or other unexpected behaviors.
Side Effects
The most common side effects of Gravol are drowsiness and dizziness, especially when taken at higher doses. Pain or irritation are also common at the injection site. It may also cause other effects like dry mouth, blurred vision, and urinary retention.
Less common but more serious reactions include allergic responses, irregular heart rhythms, confusion, and skin rashes. Some people may experience mood changes, hallucinations, or seizures. Rare blood disorders and breathing difficulties have also been reported. If you notice unusual symptoms or allergic reactions, seek medical attention right away.
References:
- Gravol Product Monograph. Mississauga, Ontario: Hikma Canada Limited; 2022.
- Dimenhydrinate Injection Drug Label Information. Lake Zurich, IL: Fresenius Kabi USA, LLC; 2025.
About Dr. Gerardo Sison (Page Author)
Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 11871