What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Hydrea (Hydroxyurea)
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Product Details
Description
HYDREA (Hydroxyurea) is a chemotherapy medication that is used to treat various types of cancer. HYDREA may be prescribed for:
- Locally advanced squamous cell carcinomas of the head and neck, in combination with chemoradiation
- Resistant chronic myeloid leukemia (CML)
HYDREA should only be used under the close supervision of a doctor specially trained to treat cancer (oncologist).HYDREA works by preventing the replication of cancerous cells. It belongs to the antimetabolite class of medications.
Directions
Take HYDREA exactly as prescribed by the doctor. The dose is individualized based on the type of tumor, disease state, risk factors, and the current standard of practice.
Ingredients
The active ingredient in HYDREA is hydroxyurea.
Fact Table
Formula
CH4N2O2
License
AU, EU EMA, US FDA
Bioavailability
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Legal status
RX Only
Chemical Name
Hydroxyurea
Elimination half-life
2-4 hours
Dosage (Strength)
500mg (100 capsules)
Pregnancy
Consult a doctor
Brands
Droxia, Hydrea, Siklos
Protein binding
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PubChem CID
3657
MedlinePlus
a682004
ChEBI
44423
ATC code
L01XX05
DrugBank
DB01005
KEGG
D00341
Routes of administration
Oral
Interactions
HYDREA has many potential drug-drug interactions. Speak with your healthcare provider if you are taking any of the following medications:
- Bacillus Calmette-Guierin
- Cladribine
- Didanosine
- Dipyrone
- Natalizumab
- Pimecrolimus
- Stavudine
- Tacrolimus
- Upacitinib
- Vaccines
Cautions
The oncologist should reduce the dose by 50% in people with moderate to severe kidney impairment.
HYDREA should not be used while pregnant and can cause harm to a developing fetus.
HYDREA causes bone marrow suppression (myelosuppression). A complete blood count (CBC) will need to be monitored regularly during treatment.
HYDREA increases sensitivity to the sun and artificial sources of ultraviolet (UV)
Side Effects
Side effects with HYDREA are common and can be severe. Tell your oncologist if you are experiencing any of the following:
- Acute mucocutaneous toxicity
- Anemia
- Asthma
- Dermatological reaction
- Eczema
- Fever
- Headache
- Infection
- Leg ulcer
- Macrocytosis
- Neutropenia
- Thrombocytopenia
- Vitamin D deficiency
- Weight gain
References
- Hydrea [package insert].Princeton, NJ: Bristol-Myers Squibb; 2016.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1559
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