What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ilevro Eye Drops (Nepafenac)
Prescription Required
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Product Details
Description
Ilevro Eye Drops (Nepafenac) is a nonsteroidal anti-inflammatory prodrug used to reduce pain and inflammation in the eyes. This medication works by blocking certain natural substances called prostaglandins in the body that cause pain and swelling. It is particularly used for treating post-cataract surgery discomfort.
Fact Table
Formula
C15H14N2O2
License
US DailyMed, EU EMA
Bioavailability
100%
Legal status
Rx-only
Chemical Name
Nepafenac
Elimination half-life
0.74 hours
Dosage (Strength)
0.3% 3 ml
Pregnancy
Not recommended for use during pregnancy
Brands
Ilevro Eye Drops
Protein binding
approximately 83.5%
PubChem CID
151075
MedlinePlus
a606007
ChEBI
75922
ATC code
S01BC10
DrugBank
DB06802
KEGG
D05143
Routes of administration
Eye Drops
Directions
Ilevro is typically applied to the affected eye once daily, beginning one day before cataract surgery, continuing on the day of surgery, and through the first two weeks of the postoperative period. An additional drop should be administered 30 to 120 minutes before surgery.
To apply the eye drops, tilt your head back and gently pull down your lower eyelid to create a small pocket. Hold the dropper directly over your eye and place one drop into the pocket. Avoid touching the dropper tip to your eye or any other surface to maintain sterility. Close your eye gently without blinking, and apply pressure to the inner corner of your eye with your finger for 1 to 2 minutes to allow the medicine to be absorbed. Make sure to wash your hands immediately after using the eye drops to remove any medicine that may be present.
Ingredients
The primary ingredient in Ilevro Eye Drops is Nepafenac, an NSAID responsible for reducing inflammation and relieving pain in the eye.
Contraindications
Avoid taking or using Ilevro Eye Drops if you have a known allergy to Nepafenac, other NSAIDs, or any ingredient in the eye drops.
Cautions
- Certain precautions may need to be taken into account before using Ilevro. Before you start using Ilevro, tell your doctor about any of the following:
- If you have ever had an allergic reaction to Ilevro, its active ingredient nepafenac, or any other non-steroidal anti-inflammatory drugs (NSAIDs).
- Medications you are currently taking, particularly other eye drops or medications that could interact with Ilevro.
- Eye conditions, such as glaucoma, diabetes, and dry eye syndrome, as well as any other health problems like diabetes, rheumatoid arthritis, or corneal denervation.
- If you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Ilevro during pregnancy and breastfeeding has not been fully studied.
- If you have had eye surgery in the past or plan to undergo eye surgery, the risk of adverse events in the eye may be increased.
- Ilevro may increase the risk of bleeding. Use this medication with caution if you have known bleeding tendencies or are taking medications that may affect bleeding.
- Ilevro and other topical NSAIDs may slow or delay healing. If you are also using topical corticosteroids, this risk may be elevated. Exercise caution and consult your healthcare provider for monitoring.
- Prolonged use of Ilevro could result in adverse effects on the cornea, such as keratitis, epithelial breakdown, and even corneal perforation. People with specific conditions like diabetes or dry eye syndrome may be at increased risk.
- Using Ilevro more than one day before surgery or beyond 14 days post-surgery could increase the risk and severity of corneal problems.
- Ilevro should not be administered while using contact lenses. Remove your contact lenses before administering the drops, and consult your healthcare provider for guidance on when it's safe to reinsert them.
Side Effects
Ilevro may cause side effects. These may include cloudiness in the eye, worsened vision, the sensation of something being in the eye, high eye pressure, and eyes feeling sticky. Most of these side effects are mild and resolve as your body adjusts to the medication.
However, more serious side effects may occur, though they are rare. Hypersensitivity reactions, delayed healing, and increased bleeding time have been reported in some cases. Other potential side effects include vision problems, increased sensitivity to light, watery eyes, crusting or drainage from the eyes, and puffy eyelids. If you experience severe side effects, consult your healthcare provider immediately.
References:
Ilevro Prescribing Information. East Hanover, NJ: Novartis; 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13847
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