Leqembi (Lecanemab)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details


    Tofidence is a biosimilar to the medication Actemra (tocilizumab), which works as an interleukin-6 (IL-6) receptor blocker. It targets and interrupts pathways of inflammation, which may be beneficial in treating various forms of arthritis. Tofidence is classified as an interleukin inhibitor and administered as an intravenous (IV) infusion by healthcare professionals.


    Tofidence is given as an IV infusion injection with strengths of 80 mg/4 mL (20 mg/mL), 200 mg/10 mL (20 mg/mL), and 400 mg/20 mL (20 mg/mL) in single-dose vials that must be diluted before use. The standard dosage and frequency depend on the specific condition being treated and the patient's body weight. For adult rheumatoid arthritis, for instance, the initial dosage is typically 4 mg/kg every four weeks, which may be increased to 8 mg/kg with close monitoring for safety. For pediatric patients, doses vary based on weight and should be determined by a healthcare professional.


    Tofidence contains tocilizumab-bavi as the main active ingredient. Inactive ingredients may include arginine hydrochloride, histidine, polysorbate 80, sucrose, and water for injection.


    Avoid using this medication if you have a known hypersensitivity to tocilizumab or any component of the product formulation.


    • Before taking Tofidence, tell your doctor about:
      • All medications you take, including prescription, over-the-counter, and herbal medicines.
      • Any medical conditions.
      • If you have a known allergy to any medications.
    • Tofidence has been associated with serious infections that can lead to hospitalization or death, including tuberculosis (TB), bacterial, fungal, viral, and other opportunistic infections. If a serious infection develops while on Tofidence, treatment should be paused until the infection is under control.
    • Before starting Tofidence, get tested for latent TB. If the test is positive, you should be treated for TB before beginning Tofidence. Even if the initial TB test is negative, continue to monitor for active TB during treatment.
    • Do not use Tofidence if you have an active infection, even a localized one. If a serious infection occurs, stop taking Tofidence until the infection is controlled.
    • Use Tofidence with caution if you are at increased risk of gastrointestinal (GI) perforation.
    • Monitor for signs of liver damage. If liver tests are persistently abnormal or if symptoms of liver disease develop, Tofidence may need to be adjusted or discontinued.
    • Regular laboratory monitoring is recommended due to potential changes in neutrophils, platelets, lipids, and liver function tests from Tofidence treatment.
    • Be aware of the risk of hypersensitivity reactions, including anaphylaxis, which can be severe and sometimes fatal.
    • Avoid live vaccines while using Tofidence.

    Side Effects

    Tofidence can cause several side effects. Common tocilizumab side effects may include headache, upper respiratory tract infections, and high blood pressure. The infusion of this medication may also cause injection site reactions, such as swelling, itching, or redness around the area of injection.

    Serious side effects may include nervous system problems and hepatitis B infection, with symptoms such as tiredness, vomiting, black, tarry stools, bloody or cloudy urine, and chills. Allergies may develop as unusual or allergic reactions to the medicine, with symptoms like dizziness, stomach pain, and shortness of breath. Seek immediate medical attention if you experience severe side effects from Tofidence.


    Tofidence (Tocilizumab) Product Monograph. Cambridge, MA: Biogen MA Inc; 2023.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14422

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