Levemir (Insulin Detemir)

Description

Levemir, also known as Insulin Detemir, is a long-acting insulin analog commonly prescribed for people with diabetes. Unlike some other forms of insulin, it consistently releases into the bloodstream, aiding in the control of blood sugar levels for up to 24 hours. Insulin detemir works by mimicking the function of natural human insulin, which is to allow cells in the body to absorb sugar (glucose) from the bloodstream to use for energy, thus lowering blood glucose levels.

Directions

Levemir is typically administered via subcutaneous injection, which is an injection under the skin. Turn the dose selector to their required number of units, which can range from 1 to 80 units depending on the specific product used such as the Levemir® FlexTouch® Pen. The initial dosing, timing and maintenance of Levemir therapy are individualized according to the person’s needs and the type of diabetes they are managing. For example, individuals may take the insulin once daily at bedtime or in some cases twice daily.

Rotate injection sites. Monitor blood glucose levels regularly and make dosage adjustments under the guidance of a healthcare professional. It's also important to keep in mind that certain factors such as weight, lifestyle, and other medications may affect insulin requirements.

Ingredients

The active ingredient in Levemir is Insulin Detemir. Inactive ingredients may include dibasic sodium phosphate, glycerin, metacresol, phenol, and sodium chloride.

Contraindications

The following points outline those who should steer clear of this insulin therapy:

• Those with a known allergy to Levemir or any of its components.
• Individuals experiencing hypoglycemia, which is an abnormally low blood sugar level.
• Patients who are children under the age of 2 as the safety and efficacy in this population have not been established.

Cautions

• Before beginning treatment with Levemir insulin, be sure to inform your healthcare provider about the following:
  • Any medical conditions you currently have
  • Any allergies
  • All medications you are currently taking
  • Whether you are pregnant or breastfeeding
• Never share your Levemir FlexPen, syringes, or needles with others, even if the needle is changed. This reduces the risk of infection transmission.
• Any changes to your insulin regimen, such as the type of insulin, the manufacturer, or how you inject, should be done under close medical supervision. You'll need to monitor your blood sugar levels more frequently during these times.
• Hypoglycemia can be severe and even life-threatening. Increase your glucose monitoring if your insulin dose, medication, diet, or physical activity levels change, especially if you have kidney or liver problems or if you don’t always notice when your blood sugar is low.
• Always double-check the insulin label before each injection to prevent accidentally using the wrong type. Mistakes in insulin type can lead to serious health risks.
• Be aware of any signs of severe allergies, such as widespread rash, difficulty breathing, or a rapid heartbeat. If you experience these symptoms after taking Levemir, stop using it and seek immediate medical attention.
• Levemir can cause potassium levels to drop, which can be dangerous. If you're at risk for low potassium levels, your doctor will monitor and treat this as needed.
• If you’re taking thiazolidinediones (TZDs) along with Levemir, watch for signs of heart failure like increased shortness of breath or swelling. Your doctor might need to adjust your medication if heart problems develop.

Side Effects

Levemir side effects include reactions at the injection site, such as pain and rash, as well as weight gain and swelling of the hands and feet. These effects are typically mild and manageable.

Levemir can cause serious conditions like hypoglycemia, which includes symptoms like dizziness, sweating, confusion, and a fast heartbeat. Immediate treatment is needed for hypoglycemia. Severe allergic reactions may occur, presenting as difficulty breathing, swelling of the face or throat, and severe drowsiness; these require urgent medical attention. Additionally, Levemir may cause low potassium levels and, when combined with certain diabetes medications, could lead to or worsen heart failure. Symptoms of heart failure to watch for include shortness of breath and swelling of the ankles. Consult a healthcare provider for other possible side effects.

References:

1. Levemir (Insulin Detemir) Product Monograph. Plainsboro, NJ: Novo Nordisk Inc.; 2022.
2. Levemir (Insulin Detemir) Drug Label Information. Plainsboro, NJ: Novo Nordisk Inc.; 2022.

About Dr. Gerardo Sison (Page Author)

Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....

Product Code : 9347