What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Palladia (Toceranib)
Prescription Required
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Product Details
Description
Palladia is an oral tablet given to dogs to treat certain skin tumors called mast cell tumors. It works by blocking several signals that help cancer cells grow and spread. More specifically, it targets several receptor tyrosine kinases (RTKs), which play a role in the growth and spread of tumors. Veterinarians prescribe Palladia for dogs with recurrent mast cell tumors that are classified as Patnaik grade II or III, whether or not nearby lymph nodes are involved.
Directions
The usual starting dosage of Palladia is 3.25 mg per kg (1.48 mg per lb) of body weight, given by mouth every other day. Palladia may be given with or without food. Tablets should never be split or crushed. A veterinarian will typically examine the dog around once per week for the first six weeks to adjust the dose if needed and about every six weeks thereafter.
Ingredients
Toceranib is the active ingredient in Palladia.
Contraindications
Avoid giving this medication in dogs that are intended for breeding or in females that are pregnant or nursing.
Cautions
- Before giving this medication, you may want to consult a veterinarian about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
- Palladia is for dogs only. Keep it out of reach of children, and wear gloves when handling broken or wet tablets or cleaning up your dog’s waste. Pregnant women should avoid handling the medication, as accidentally taking it could harm an unborn baby.
- This medication can affect blood vessels, sometimes causing swelling or blood clots, including serious lung clots. If this occurs, treatment may be stopped. Surgery should be delayed for at least 3 days after the last dose.
- Regular blood tests may be needed during treatment. Palladia may be paused or given at a lower dose if blood cell counts, kidney values, or protein levels are abnormal.
- Dogs with certain mast cell tumors may have a higher risk of severe reactions when starting this medication. If swelling, severe diarrhea, or bleeding occurs, treatment may need to be stopped or adjusted.
- Palladia is processed by the liver, and some medications can change how it works or increase side effects. Tell your vet about all other medications, especially NSAIDs, as they can increase the risk of stomach problems.
- This drug has not been tested in dogs under 2 years old or weighing less than 5 kg (about 11 lbs).
Side Effects
The most common side effects seen with Palladia in dogs include diarrhea, loss of appetite, vomiting, and lethargy. Other commonly reported reactions included weight loss, blood in the stool, dehydration, skin changes, and itching. Laboratory changes such as low white blood cell count, low platelets, and increased liver enzymes have also been observed.
More serious side effects may include gastrointestinal bleeding, ulcers, and significant weight loss. Other rare but serious effects such as vascular disorders, organ failure, and gastric or intestinal perforation have been reported, with some resulting in death. Neurological signs, ear infections, and nosebleeds have also occurred. If any unusual signs develop, consult a veterinarian.
References:
- Palladia (Toceranib) Drug Label Information. Kalamazoo, MI: Zoetis Inc.; 2018.
- Palladia (Toceranib) Prescribing Information. Kalamazoo, MI: Zoetis Inc.; 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 15292
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