What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Proglycem (Diazoxide)
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Product Details
Description
Proglycem, also known by its generic name Diazoxide, is an orally administered medication used to manage hypoglycemia, a condition characterized by abnormally low blood sugar levels. Classified as a non diuretic benzothiadiazine derivative, Proglycem works by blocking insulin release from the pancreas, which can help increase and stabilize blood sugar levels. Doctors typically prescribe this medication for individuals experiencing hypoglycemia due to certain pancreatic cancers or other conditions leading to excess insulin secretion.
Directions
When taking a Proglycem, it's crucial to follow your doctor's specific instructions. Typically, Proglycem is administered orally, and patients should take it consistently to achieve the best results. The usual dosage ranges according to individual needs, but as a general guideline, adults might start with a dosage of 3 mg/kg per day, divided into three equal doses. For ongoing treatment, the dose may be adjusted based on the patient's response and blood sugar levels. It’s important to note that you shouldn’t adjust your dose unless directed by your healthcare provider.
Ingredients
Proglycem contains the active ingredient Diazoxide.
Contraindications
Avoid taking or using this medication if any of the following apply:
- Known hypersensitivity to Diazoxide or related compounds
- Allergic reactions to thiazides or sulfonamide derivatives
- Presence of functional hypoglycemia—a condition not caused by a pancreatic tumor
Cautions
- Talk to a healthcare provider about all of the following before using Proglycem:
- Any existing allergies
- Whether you are pregnant or breastfeeding
- Other medical conditions you may have
- All current medications you are taking
- Proglycem can cause your body to hold onto more fluid than usual. This might be a problem for people with heart issues, as it can lead to heart failure. However, this fluid retention can usually be managed with water pills (diuretics).
- While Proglycem is used to treat low blood sugar, it can sometimes make your blood sugar too high. If you're also taking water pills for blood pressure (thiazides), they can make this effect stronger. It's crucial to monitor your blood sugar closely while on Proglycem.
- In some cases, Proglycem can lead to severe conditions like ketoacidosis or a type of coma related to very high blood sugar, especially if you're sick with something else. Keeping an eye on your urine for sugar and ketone levels is important. If you notice anything unusual, you should contact your doctor immediately.
- There have been reports of temporary cataracts in some patients, especially in babies, linked to very high blood sugar levels. Cataracts have also been seen in animals given Proglycem.
- Long-term use of Proglycem in children has been linked to changes in facial appearance in a few cases.
- Some infants and newborns treated with Proglycem have developed pulmonary hypertension, a serious lung condition, but it usually goes away once the medication is stopped. It's important to watch for signs of breathing difficulties and consult your doctor if they occur.
- Regular checks for sugar and ketones in your urine are advised, especially during stressful times. Your doctor will also periodically check your blood sugar levels to adjust the dose if needed.
- Proglycem can interact with other medications, including blood pressure medicines (making them more potent) and blood thinners. It may also affect newborns with jaundice.
- Be aware that Proglycem has been linked to lung issues in very young patients. Watch for any signs of respiratory distress.
Side Effects
Proglycem capsules may lead to water and salt retention, which might cause heart problems in some people but often gets better with water pills. It's also common to see unusual hair growth on different parts of the body, which goes away after stopping the medicine. Some people might experience high blood sugar, stomach upset, fast heartbeat, and increased uric acid levels.
In rare cases, Proglycem can cause serious conditions like diabetic ketoacidosis, which needs immediate treatment. Blood issues, such as low platelet counts, might lead to stopping the medication. Other severe effects include low blood pressure, problems with liver and kidneys, nervous system issues like anxiety and dizziness, eye problems, and other significant reactions like chest pain or fever. It's important to talk to a doctor if any serious health concerns arise while taking a Proglycem.
References:
- Proglycem (Diazoxide) Product Monograph. Parsippany, NJ: Teva Pharmaceuticals; 2022.
- Proglycem (Diazoxide) Drug Label Information. Parsippany, NJ: Teva Pharmaceuticals; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1746
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