Description
Rybelsus is a GLP-receptor agonist prescription medication. It is used for treatment of Type 2 diabetes and works to manage blood sugar levels. However, it works very differently from similar diabetes medications in that it has a unique 3-way approach to lowering blood sugar. The advantage of Rybelsus is that it promotes increased insulin production from the pancreas, decreases sugar released from the liver, and slows the release of food from the stomach after eating.
GLP-1 stands for glucagon-like Peptide 1, and Rybelsus works like your body's naturally occurring GLP-1 to lower blood sugar. Rybelsus is not to be used as a primary treatment for Type 2 diabetes, and instead should be used to supplement other primary diabetic medications as only as directed by a physician.
| Fact Table |
| Formula |
C187H291N45O59 |
| License |
EU EMA, US FDA |
| Bioavailability |
89% |
| Legal status |
RX Only |
| Chemical Name |
Semaglutide |
| Elimination half-life |
1 week |
| Dosage (Strength) |
3mg (30 or 90 tablets), 7mg (30 or 90 tablets), 14mg (30 or 90 tablets) |
| Pregnancy |
Consult a doctor |
| Brands |
Rybelsus |
| Protein binding |
- |
| PubChem CID |
56843331 |
| MedlinePlus |
a618008 |
| ChEBI |
167574 |
| ATC code |
A10BJ06 |
| DrugBank |
DB13928 |
| KEGG |
D10025 |
| Routes of administration |
By mouth (tablets) |
Directions
Take Rybelsus on an empty stomach when you first wake up. Do not exceed 4 fluid ounces of water when taking this diabetes medication. Wait 30 minutes before eating, drinking, or taking other medications. A missed dose is okay, but be sure to take your next dose of Rybelsus at the same the next day.
Ingredients
The active ingredient in Rybelsus for Type 2 diabetes is Semaglutide.
Cautions
Do not use Rybelsus as a blood sugar lowering medication if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Do use Rybelsus is you are allergic to Semaglutide or any of the ingredients in this Type 2 diabetes medication.
Keep Rybelsus tablets in the blister pack until you are ready to take them / Push tablet out of blister. Do not cut from the packaging / Swallow tablet whole. Do not cut, crush, or chew.
Store at room temperature 68°F–77°F (20°C–25°C).
Store in a dry place away from moisture.
Interactions
There are no established interaction risks between Rybelsus medication for Type 2 diabetes, but you should inform your doctor of all medicines and supplements you are taking before having them write you a prescription for Rybelsus.
Side Effects
Side effects related to the use of this blood sugar lowering medication are uncommon, but may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation.
If any of these symptoms or more serious ones occur then you must discontinue use of the medication immediately and speak with your physician regarding blood glucose lowering medication alternatives.
Frequently Asked Questions about Rybelsus (semaglutide)
What is Rybelsus?
Rybelsus, also known as semaglutide, is a once-daily tablet for adults with type 2 diabetes. It helps manage blood sugar levels when combined with diet and exercise.
What is the difference between Rybelsus and Ozempic?
Rybelsus and Ozempic are both medications used to treat type 2 diabetes. Both contain the active ingredient semaglutide, a GLP-1 agonist. Rybelsus is an oral tablet, while Ozempic is a weekly subcutaneous injection. Both result in significant weight loss.
Is Rybelsus the same as wegovy?
Rybelsus and Wegovy both contain the active ingredient semaglutide. However, they serve different purposes: Rybelsus is used to treat type 2 diabetes in adults, while Wegovy is specifically approved for chronic weight management in certain adults and adolescents, administered as a weekly subcutaneous injection with more significant weight loss results.
Is Rybelsus (Semaglutide) safe?
While animal studies suggest a thyroid cancer risk, human studies are inconclusive. Overall, the risk/benefit profile of Rybelsus is favorable for patients with diabetes. If you have a history of thyroid cancer or other medical conditions, your doctor can guide you on the best treatment options.
How much weight can you lose with Rybelsus?
Rybelsus, although not specifically designed for weight loss, has been associated with an average weight loss of 5 pounds (2.3 kg) for the 7 mg dose and 8.1 pounds (3.7 kg) for the 14 mg dose. It works by helping individuals feel full after meals and belongs to the class of GLP-1 receptor agonists.
what is Rybelsus used for?
Rybelsus (semaglutide) is a medication used for type 2 diabetes. It works by increasing insulin release, reducing sugar production from the liver, and slowing stomach emptying after meals. Before starting this treatment, consult your healthcare provider and be aware that it is not suitable for individuals with type 1 diabetes or a history of pancreatitis.
does Rybelsus work if you drink water?
Yes, Rybelsus works if you drink water. It’s essential to take it on an empty stomach, 30 minutes before food, with a small amount of water for optimal absorption.
What are the side effects of Rybelsus?
Some common side effects of Rybelsus (semaglutide) include Nausea, Vomiting, Diarrhea Abdominal pain, Constipation, Decreased appetite. There is also a risk of thyroid C-cell tumors (especially in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2).
Is Rybelsus available in canada?
Rybelsus (semaglutide tablets) is indeed available in Canada! It was approved by Health Canada as a treatment option for adults with type 2 diabetes mellitus, along with diet and exercise. Rybelsus is the first and only glucagon-like peptide-1 (GLP-1) analogue available in a tablet form.
Which is safer Ozempic or Rybelsus?
Ozempic is recommended for people with heart disease due to its FDA-approved benefit of lowering heart attack and stroke risk in type 2 diabetes. Rybelsus lacks this specific approval.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13506
Prescription Required
