What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Synvisc - One (Hylan)


Synvisc - One (Hylan)

Prescription Required

48mg / 6ml

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  • Product Details


    Synvisc One (Hylan) is an injectable lubricant made from a natural substance called hyaluronan. It is used to treat osteoarthritis of the knee, specifically for patients who have failed other therapies. Synvisc One works by lubricating the joint and providing shock support to decrease pain and improve mobility. A single treatment of Synvisc One can provide pain relief for up to six months. You can buy Synvisc One as a 48mg/6mL syringe. Keep Synvisc One stored in its original packaging at room temperature.


    • Synvisc One is administered as an injection in your physician's office. They will numb the injection site with a topical numbing agent. They will also numb the joint with an injectable numbing agent.
    • Click here to watch a video describing a Synvisc knee injection.
    • Synvisc One is administered as a single injection of 6mL into the knee joint.


    • The active ingredient in Synvisc One is hylan G-F 20.

    Fact Table




    US FDA



    Legal status

    US: RX Only

    Chemical Name

    Hylan G-F 20

    Elimination half-life


    Dosage (Strength)



    Consult a doctor


    Synvisc One

    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    • Synvisc One should only be injected by a healthcare practitioner.
    • Avoid Synvisc One if you have a known allergy to hyaluronan.
    • Synvisc One should not be injected into infected skin.
    • Synvisc One is only approved for use in the knee.
    • Discuss the risk of using Synvisc One if you have allergies to birds, feathers, or eggs.
    • Do not use Synvisc if the packaging appears damaged or previously opened.
    • If you are pregnant or considering becoming pregnant, discuss the risks of Synvisc with your physician.
    • Synvisc is not approved for patients under the age of 21.

    Side Effects

    Synvisc side effects include:

    • Mild to moderate pain at the injection site.
    • Swelling of the injection site.
    • Pain in the joint
    • Stiffness of the joint
    • Fluid build-up around the joint
    • Joint warmth
    • Swelling

    Other Considerations

    • You can also buy Synvisc that is administered as three separate injections.



    1. Osteoarthritis knee pain RELIEF: Synvisc-one® (Hylan G-f 20): For HCPs. (2019).. Retrieved March 22, 2020
    2. Hylan Polymers A and B. (n.d.). Retrieved March 22, 2020

    Frequently Asked Questions about Synvisc-One (Hylan)

    What is Synvisc-One (Hylan)?

    Synvisc-One (Hylan) is an injectable treatment used to relieve knee pain caused by osteoarthritis (OA) when other treatments have not provided adequate relief.

    How does Synvisc-One work?

    Synvisc-One supplements the fluid in your knee to help lubricate and cushion the joint, which can provide up to six months of osteoarthritis knee pain relief.

    How is Synvisc-One administered?

    Synvisc-One is administered as a single injection directly into the knee joint by a healthcare professional.

    How long does the relief from Synvisc-One last?

    The pain relief from a Synvisc-One injection can last up to six months. However, individual results may vary.

    Are there any side effects associated with Synvisc-One?

    Common side effects include pain, swelling, heat, redness, and/or fluid build-up in or around the knee. It's essential to discuss any concerns with your healthcare provider.

    Who should not receive Synvisc-One?

    Patients with a known allergy to hyaluronan products, those with an infected knee joint, or those with skin diseases or infections around the injection site should not receive Synvisc-One.

    Can I receive Synvisc-One if I'm taking other medications?

    Always inform your healthcare provider about all the medications you're taking. They will guide you on whether Synvisc-One is appropriate for you.

    How soon can I return to my regular activities after receiving the injection?

    It's generally recommended to avoid strenuous activities for about 48 hours after the injection. However, always follow your healthcare provider's advice.

    How is Synvisc-One different from other hyaluronic acid treatments?

    Synvisc-One requires only one injection, whereas some other hyaluronic acid treatments might require multiple injections over several weeks.

    Is Synvisc-One covered by insurance?

    Coverage varies by insurance provider and plan. It's best to check with your insurance company to determine if Synvisc-One is covered.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9743

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