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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tabloid (Tioguanine)
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Product Details
Description
Tabloid, also known as Thioguanine, is categorized as a purine analog used in chemotherapy. It works by disrupting the production of nucleic acid, crucial for cell replication. Mainly prescribed to treat certain forms of leukemia, like acute nonlymphocytic leukemia (ANLL), Thioguanine is highly potent and should be administered only under the supervision of a healthcare provider skilled in cancer chemotherapy. Its usage is limited to the management of particular cancerous conditions and is not intended for general use.
Directions
Tabloid tablets are meant to be taken by mouth. Patients should strictly adhere to the dosing schedules recommended by their healthcare provider. The tablet dosage forms may vary based on the specific type and stage of the cancer being treated. Typically used in combination with other chemotherapy drugs, Tabloid is part of a treatment regimen for certain types of leukemia. It is important to follow medical advice regarding the timing and consistency of medication intake to maximize the effectiveness of the therapy.
Ingredients
Tabloid contains the active ingredient Thioguanine.
Contraindications
Health care providers generally advise against taking Tabloid in the following circumstances:
- Individuals who have shown previous resistance to Thioguanine or related medications such as mercaptopurine.
- Those with a history of hypersensitivity reactions to Thioguanine or any component in the formulation.
Cautions
- Before beginning treatment with Tabloid, it's important to discuss the following with your healthcare provider:
- Your current health conditions
- Any allergies you may have
- All medications you are currently using
- Whether you are pregnant or breastfeeding
- Thioguanine should only be administered by doctors experienced with its effects and risks, especially for treating certain types of leukemia.
- It's not recommended for long-term continuous treatments like maintenance therapy due to serious risks of liver toxicity.
- Stop using Thioguanine if signs of liver toxicity appear, such as yellowing of the skin or eyes, pain in the upper right belly, or swelling due to fluid retention.
- Regular blood tests are important to monitor for early signs of liver issues, such as low platelets or enlarged spleen, and changes in liver enzymes might not always be present.
- Common severe side effects include bone marrow suppression, which can cause anemia, a decrease in white blood cells, and low platelets. If blood counts drop significantly, Thioguanine should be temporarily stopped.
- Before starting Thioguanine, testing for TPMT or NUDT15 deficiency is advisable as it can affect how you respond to the medication. Patients with deficiencies in these enzymes may need lower doses.
- Patients must be monitored for serious infections and bleeding due to the effects of Thioguanine on bone marrow.
- Thioguanine can cause birth defects; women of childbearing potential should avoid pregnancy and use effective contraception during treatment.
- Avoid live vaccines during Thioguanine treatment due to the increased risk of infection.
- Inform your doctor immediately if you experience symptoms like fever, unusual bleeding, or signs of infection.
- Regular liver function tests are recommended during treatment, especially if you have pre-existing liver conditions or are taking other drugs that affect the liver.
Side Effects
Thioguanine often leads to a decrease in all types of blood cells, a typical side effect in leukemia treatment. It also commonly causes increased levels of uric acid due to rapid cell breakdown, which can be managed with more fluids and specific medications like allopurinol. Other less common Thioguanine side effects include nausea, vomiting, loss of appetite, and mouth sores, with rare but serious issues like intestinal damage occurring in some cases.
Liver damage is a significant risk with Thioguanine, especially during long periods of treatment, which are generally not recommended. Symptoms might include jaundice (yellowing of the skin and eyes), swelling in the abdomen, and pain. Changes in the liver may include scarring and blockages. If Thioguanine is stopped, these liver issues might improve. Monitoring by a healthcare provider is crucial, and the medication may need to be stopped if severe liver damage develops.
References:
- Tabloid (Thioguanine) Product Monograph. Mason, OH: Aspen Global, Inc.; 2018.
- Tabloid (Tioguanine) Drug Label Information. Mason, OH: Aspen Global, Inc.; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13891
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