What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Nolvadex (Tamoxifen)
Prescription Required
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Product Details
Description
Nolvadex is a medication used:
- to treat breast cancer that has spread to other parts of the body in women and men
- to treat breast cancer after mastectomy, axillary dissection, and breast irradiation in postmenopausal women
- to reduce the risk of invasive breast cancer after surgery and radiation in women with ductal carcinoma in situ (DCIS)
- to reduce the incidence of breast cancer in high-risk women
Nolvadex is available in 10 mg and 20 mg oral tablets.
Directions
Take Nolvadex exactly as your healthcare provider has prescribed. Talk to your healthcare provider or pharmacist about any questions or concerns you have.
Each patient's Nolvadex dose and duration of treatment depends on the reason for its use.
Ingredients
Each Nolvadex tablet contains tamoxifen citrate. Inactive ingredients include carboxymethylcellulose calcium, magnesium stearate, mannitol, and starch.
Fact Table
Formula
C26H29NO
License
US FDA
Bioavailability
100%
Legal status
US: RX Only
Chemical Name
Tamoxifen
Elimination half-life
5-7 days
Dosage (Strength)
10mg (60 tablets), 20mg (90 tablets)
Pregnancy
Consult a doctor
Brands
Nolvadex, Soltamox
Protein binding
Greater than 99%
PubChem CID
2733526
MedlinePlus
a682414
ChEBI
41774
ATC code
L02BA01
DrugBank
DB00675
KEGG
D08559
Routes of administration
By mouth (tablets)
Contraindications
Do not take Nolvadex if you are allergic to the medication or to any of its ingredients.
Do not take Nolvadex if you take coumarin-type blood thinners or if you have a history of blood clots in the legs or lungs.
Cautions
Nolvadex has the following FDA Boxed Warning:
- Serious and life-threatening events, including uterine malignancies, stroke, and blood clots in the lungs, can occur in women with DCIS and in women who are at high risk for breast cancer.
- Before you start treatment with Nolvadex, be sure to tell your healthcare provider about:
- All the medications you take
- Your allergies
- Your health history and current health problems
- Your pregnancy or breastfeeding status
- Endometrial changes have been reported with Nolvadex treatment.
- Nolvadex can increase the risk of blood clots.
- Liver changes have occurred with Nolvadex treatment.
- Second primary tumors have been reported with Nolvadex treatment.
- Vision problems and eye changes have been reported with Nolvadex treatment.
- Nolvadex can cause harm to an unborn baby. Women of child-bearing age should avoid becoming pregnant while being treated with Nolvadex and within 2 months of stopping Nolvadex. Effective barrier or non-hormonal birth control measures should be used.
Side Effects
Nolvadex side effects include bone and tumor pain, hot flashes, high blood calcium levels, swelling, distaste for food, vulvar itching, depression, dizziness, light-headedness, headache, hair thinning and/or partial hair loss, and vaginal dryness.
If you have any side effects that bother you or persist, contact your healthcare provider right away.
Reference:
Nolvadex. AstraZeneca Pharmaceuticals, LP; 2004.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1825
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