Tremfya (Guselkumab)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details


    Tremfya (Guselkumab) is a monoclonal antibody that targets interleukin-23, a protein involved in inflammation. It is used for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis in adults. By blocking the action of interleukin-23, Tremfya helps to reduce inflammation and slow down the rapid growth of skin cells associated with psoriasis.

    Fact Table




    US DailyMed



    Legal status


    Chemical Name


    Elimination half-life

    17 days

    Dosage (Strength)

    prefilled syringe single-dose 100mg/mL, one-Press patient-controlled injector single-dose 100mg/mL


    Consult Doctor



    Protein binding


    PubChem CID

    Not Assigned




    Not Assigned

    ATC code






    Routes of administration



    Before administering Tremfya, ensure that you have the correct single-dose prefilled syringe containing one 100 mg dose. Keep in mind that each prefilled syringe can only be used once, after which it should be discarded, even if there is medicine left in it.

    Before injecting Tremfya, clean the injection site with an alcohol swab and allow it to air dry. Carefully remove the needle cap from the prefilled syringe, then hold it at a 90-degree angle to the skin. Gently pinch the skin and insert the needle fully into the pinched skin. Press the plunger down to release the medication. Once the injection is complete, remove the needle in a swift motion and apply pressure to the site with a cotton ball or gauze pad.

    Follow your doctor's specific instructions regarding Tremfya dosing. They will determine the most appropriate treatment plan for your individual needs. If you miss a scheduled dose, contact your healthcare provider for guidance on when to take the next dose.


    Tremfya consists of a human immunoglobulin G1 lambda (IgG1?) monoclonal antibody called Guselkumab. As a subcutaneous injection, Tremfya also may also contain additional inactive ingredients, such as buffering agents, stabilizers, or preservatives.


    Patients who are allergic to Guselkumab or Polysorbate 80 should not use Tremfya, as it may cause hypersensitivity reactions. If you have experienced an allergic reaction to either of these ingredients in the past, inform your healthcare provider.


    • Before starting treatment with Tremfya, discuss with your healthcare provider the following:
      • Any medical conditions you have
      • Any medications you take
    • Any signs of hypersensitivity you have experienced in the past, as Tremfya can cause serious allergic reactions, including anaphylaxis. If you've had severe allergic reactions to other medications, you may be at an increased risk for a reaction to Tremfya.
    • Inform your healthcare provider of any existing medical conditions, particularly if they pertain to your immune system. Since Tremfya can increase the risk of infections, it's important to let your healthcare provider know if you frequently get infections or have symptoms of an infection. You should be instructed to seek medical advice immediately if you notice signs or symptoms of a chronic or acute infection.
    • Do not take Tremfya if you have an active serious infection or if a serious infection develops while on Tremfya. Your healthcare provider may decide to discontinue treatment until the infection resolves.
    • It is also important to be evaluated for tuberculosis (TB) before starting Tremfya. If you have a history of TB, if someone in your household has TB, or if you have recently traveled to places where TB is common, make sure to inform your healthcare provider. An assessment for TB might include a skin test or a blood test.
    • Breastfeeding or pregnant patients should discuss the potential risks and benefits of taking Tremfya with their healthcare provider.
    • Since Tremfya is for long-term treatment of conditions like plaque psoriasis and psoriatic arthritis, it should not be used to treat sudden episodes of these conditions.

    Side Effects

    Like other medications, Tremfya may cause mild or serious side effects. The most common Tremfya side effects may include headache, diarrhea, joint pain, and respiratory tract infections. In addition, Tremfya may cause injection site reactions, such as redness or swelling around the area of injection.

    Serious side effects may include serious allergic reactions or infections. Seek medical assistance if you experience chest tightness, swelling of the face or mouth, trouble breathing, fever, or severe muscle aches. This is not a complete list of side effects.


    1. Tremfya (Guselkumab) Product Monograph. Horsham, PA: Janssen Biotech, Inc.; 2020.
    2. Tremfya (Guselkumab) Drug Label Information. Horsham, PA: Janssen Biotech, Inc.; 2023.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14402

  • Product Reviews


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