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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
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Vetoryl (Trilostane)
Prescription Required
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Product Details
Description
Vetoryl (trilostane) is a prescription medication used to treat Cushing’s disease (hyperadrenocorticism) in dogs. This condition happens when a dog’s body makes too much cortisol, a stress hormone, which can cause excessive thirst and urination, increased hunger, a pot belly, hair loss, and low energy. Vetoryl helps lower cortisol production and is given by mouth with food. It comes in several capsule strengths and should be used only under regular veterinary care.
Fact Table
Formula
C20H27NO3
License
US FDA, NADA #141-291
Bioavailability
Oral absorption enhanced with food; absolute bioavailability not reported
Legal status
Veterinary Rx-only
Chemical Name
Trilostane; 4a,5a-epoxy-17ß-hydroxy-3-oxoandrostane-2a-carbonitrile
Elimination half-life
About 2.8 hours in fed dogs for Vetoryl hard capsules; range 1.2–8.7 hours
Dosage (Strength)
Capsules: 5 mg, 10 mg, 20 mg, 30 mg, 60 mg, 120 mg; starting dose 1–3 mg/lb (2.2–6.7 mg/kg) orally once daily with food
Pregnancy
Do not use in pregnant dogs; pregnant women should avoid handling capsules
Brands
Vetoryl, Desopan, Modrenal, Modrastane, Trilocur, Trilorale
Protein binding
Not available
PubChem CID
656583
MedlinePlus
Not available
ChEBI
32260
ATC code
QH02CA01 (ATCvet); H02CA01 (ATC)
DrugBank
DB01108
KEGG
D01180
Routes of administration
Oral
Directions
Give Vetoryl exactly as your veterinarian prescribes. Give the capsule by mouth once a day with food, and do not open, crush, or split it. The dose is based on your dog’s weight and may be changed after follow-up tests. Your veterinarian will schedule regular checkups and blood tests, usually 10 to 14 days after starting Vetoryl or changing the dose.
Contact your veterinarian and stop giving the medicine if your dog vomits, has diarrhea, seems weak or very tired, stops eating, or collapses. If you miss a dose, give the next dose at the regular time. Do not give two doses at once.
Ingredients
The active ingredient in Vetoryl is trilostan.
Cautions
Before using this medication, you may want to consult a veterinarian about the following:
- Any existing health conditions your dog has, especially liver, kidney, or heart disease
- Any known allergies
- A list of all medications your dog is currently taking
Vetoryl can cause hypoadrenocorticism, or an underactive adrenal gland, in which cortisol drops too low. This can happen at any dose and at any time. In some dogs, adrenal function takes months to recover, and occasionally it does not fully return.
Serious adverse reactions can occur without warning and, in some cases, can be fatal. Stop the medication and contact your veterinarian immediately if your dog shows vomiting, diarrhea, poor appetite, lethargy, weakness, or collapse.
Use caution when combining Vetoryl with ACE inhibitors, such as enalapril or benazepril, as both lower aldosterone and the effects may add together. Potassium-sparing diuretics such as spironolactone should not be used with Vetoryl because of the risk of high potassium levels.
If your dog was previously treated with mitotane, your veterinarian will usually wait at least a month before starting Vetoryl, as the adrenal glands may be more sensitive to its effects.
The safe use of Vetoryl has not been established in lactating, or nursing, dogs or in male dogs intended for breeding.
This product is for dogs only and not for human use. Keep out of reach of children. Wash your hands after handling the capsules. Do not handle the capsules if you are pregnant or trying to conceive, and do not open the capsules. If a person accidentally swallows a capsule, seek medical advice immediately and bring the labeled container.
Store at controlled room temperature, around 25°C (77°F), with brief excursions permitted between 15°C and 30°C (59°F to 86°F).
Contraindications
Avoid using this medication if any of the following apply:
- A known allergy or hypersensitivity to trilostane.
- Dogs with primary liver disease.
- Dogs with kidney, or renal, insufficiency.
- Pregnant dogs, as trilostane has caused birth defects and early pregnancy loss in laboratory animal studies.
Side Effects
Common side effects of Vetoryl include:
- Reduced or poor appetite
- Vomiting
- Diarrhea or loose stools
- Lethargy or dullness
- Weakness
- Shaking or shivering
More serious reactions can occur and may happen suddenly. These can include severe depression, bloody diarrhea, collapse, and a hypoadrenal crisis, when cortisol and electrolytes fall to dangerous levels, as well as damage to the adrenal glands, including adrenal necrosis or rupture. Stop giving Vetoryl and contact your veterinarian or an emergency clinic if your dog becomes very weak, collapses, refuses to eat, vomits repeatedly, or has bloody diarrhea. Signs of low adrenal function and electrolyte changes, such as high potassium and low sodium, can occur and need to be treated.
References
Vetoryl Prescribing Information. Overland Park, KS: Dechra Veterinary Products; 2024.
Vetoryl Drug Label Information. Overland Park, KS: Dechra Veterinary Products; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 15296
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