What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Wixela (Fluticasone / Salmeterol)


Wixela (Fluticasone / Salmeterol)

Prescription Required

100mcg / 50mcg (60 doses)
250mcg / 50mcg (60 doses)
500mcg / 50mcg (60 doses)

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  • Product Details


    Wixela (Fluticasone / Salmeterol) is a combination of two medications that work together to help manage and improve symptoms of asthma and chronic obstructive pulmonary disease (COPD). Fluticasone, a corticosteroid, acts as an anti-inflammatory agent to reduce the swelling and irritation in the airways. Salmeterol, a long-acting beta-adrenergic agonist (LABA), works as a bronchodilator, helping to relax and open the airways for easier breathing.

    Fact Table


    Fluticasone: C22H27F3O4S Salmeterol: C25H37NO4


    US FDA, US DailyMed, EU EMA


    Fluticasone: 1%, Salmeterol: about 4%

    Legal status


    Chemical Name

    Fluticasone / Salmeterol

    Elimination half-life

    5.5 to 7.8 hours

    Dosage (Strength)

    100mcg / 50mcg (60 doses), 250mcg / 50mcg (60 doses), 500mcg / 50mcg (60 doses)


    Consult Doctor



    Protein binding

    Fluticasone: 99% Salmeterol: 96%

    PubChem CID

    Fluticasone: 5311101 Salmeterol: 5152




    Fluticasone: 31441 Salmeterol: 9014

    ATC code



    Fluticasone: DB00588 Salmeterol: DB00938


    Fluticasone: D07981 Salmeterol: D00687

    Routes of administration



    To use the inhaler, hold it in the left hand and place the right thumb in the thumb grip. Push the thumb grip away until the mouthpiece shows and snaps into place1. Slide the lever until a click is heard. Inhale the medication according to the prescribed dosage, ensuring not to exceed the doctor's recommendations.

    After administering a Wixela dose, it is advised to rinse the mouth with water without swallowing. This helps reduce the risk of oral fungal infections. It is crucial to note that Wixela is not intended for relieving an asthma attack that has already started. For such situations, a rescue inhaler should be used.


    Wixela Inhub is a combination medication containing two active ingredients: fluticasone propionate and salmeterol inhalation powder.


    Contraindications for using this medication include:

    • Severe hypersensitivity to milk proteins
    • Known hypersensitivity to fluticasone propionate, salmeterol, or any of the excipients
    • Use of another drug with similar active ingredients


    • Some important considerations before starting treatment with Wixela include:
      • Allergies to Wixela Inhub, its components (fluticasone and salmeterol), or other substances
      • Other medications you are using, especially those similar to Wixela Inhub
      • Any medical conditions you have
    • If you have worsening asthma or COPD, Taltz should not be started. It is not for treating sudden breathing problems.
    • Do not mix Taltz with other drugs that contain long-acting beta-agonists, as it can lead to too much medicine in your body.
    • If you're moving from steroid pills to Taltz, do it slowly to avoid affecting your adrenal glands, which help control stress responses and metabolism.
    • You might get a yeast infection in your mouth or throat. To help prevent this, rinse your mouth with water without swallowing after using Taltz.
    • Using a lot of Taltz, or sometimes even the usual amount, can lead to conditions like hypercorticism and adrenal suppression. If this happens, you may need to stop Taltz.
    • For those with COPD, there's a greater chance of getting pneumonia. Keep an eye out for cough or fever, and let your doctor know if these show up.
    • If you have infections like tuberculosis or herpes, Taltz could make them more severe. Be cautious and check with your doctor if you have any ongoing infections.
    • If your breathing suddenly gets worse after Taltz, stop using it right away and look for another treatment.
    • If you have heart or brain conditions, be careful with Taltz because it can stimulate your body in ways that may affect these conditions.
    • Taltz can affect the health of your bones. Your doctor might check this regularly.
    • Keep an eye on how children grow when they're on Taltz, as it can affect their growth rate.
    • Long-term use of Taltz can lead to eye issues like glaucoma and cataracts. If you notice any changes in your vision, you may need to see an eye specialist.
    • Watch out for signs of low potassium or high blood sugar, especially if you have conditions related to these levels.

    Side Effects

    Individuals taking Wixela may experience a range of adverse effects. Common Wixela side effects may include headaches, throat irritation, coughing, feelings of nausea, and voice changes.

    In addition, Wixela Inhub has been linked to more serious complications that may need prompt medical intervention. Such complications may include infections of the lungs, sudden breathing problems, adrenal gland problems, heart issues, reduction in bone density, vision concerns, slowed growth in children, and severe allergic reactions. Should you notice any severe side effects, consult a healthcare professional immediately.


    1. Wixela (Fluticasone / Salmeterol) Product Monograph. Morgantown, WV: Mylan Pharmaceuticals; 2019.
    2. Wixela (Fluticasone / Salmeterol) Drug Label Information. Morgantown, WV: Mylan Pharmaceuticals; 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14407

  • Product Reviews


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