What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zavesca (Miglustat)
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Product Details
Description
Zavesca (Miglustat) is an oral medication classified as a glucosylceramide synthase inhibitor. It works by blocking the enzyme glucosylceramide synthase, which plays a role in the production of glycosphingolipids. Glycosphingolipids are fatty substances found in cell membranes that are important for cell communication and function. Zavesca is primarily used to treat mild to moderate type 1 Gaucher disease in adults who are not suitable for enzyme replacement therapy.
Directions
To take Zavesca, follow your healthcare provider's instructions precisely. The standard dosage is one 100-mg capsule taken three times daily at regular intervals. If a patient experiences tremor or diarrhea, the healthcare provider may reduce the dose to 100 mg once or twice daily. Always take Zavesca at the same time each day. If a dose is missed, skip that dose and continue with the next dose at the regular time. Do not double the dose.
Ingredients
The active ingredient in Zavesca is Miglustat.
Contraindications
Avoid taking or using this medication if any of the following apply:
- You have severe kidney problems
- You are pregnant
- You are under 18 years old without medical advice
Cautions
- Before starting treatment with Zavesca, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- If you're taking Zavesca, it’s important to have regular check-ups for nerve health, as some people develop peripheral neuropathy, which can include symptoms like pain, weakness, numbness, and tingling. If these symptoms occur, re-evaluating the benefits versus risks of continuing Zavesca may be necessary.
- About 30% of people may experience hand tremors when starting Zavesca, typically within the first month. These usually improve on their own but if they don’t, adjusting the dose or stopping the medication might be considered.
- Many people experience diarrhea and weight loss with Zavesca due to its effects on sugar digestion. Managing your diet by reducing sugar intake and possibly using anti-diarrheal medications like loperamide can help. If diarrhea persists despite these changes, it’s important to check for other underlying digestive issues.
- Zavesca can sometimes reduce platelet counts, which are important for blood clotting. Regular blood tests to monitor platelets are recommended, especially if you have Gaucher's disease and are switching from enzyme replacement therapy to Zavesca.
- If you experience diarrhea while on Zavesca, try adjusting your diet to reduce sugars and carbohydrates, which might help manage symptoms. Take Zavesca between meals to potentially reduce gastrointestinal side effects.
Side Effects
Zavesca may cause side effects. The most common ones include weight loss, stomach pain, gas, nausea, vomiting, headaches, back pain, and constipation. Some people may also experience dry mouth, muscle cramps, dizziness, vision problems, and changes in their menstrual cycle. These side effects are usually manageable but can occasionally be bothersome.
Zavesca can cause more serious side effects such as peripheral neuropathy, which is numbness, tingling, pain, or burning in the hands or feet. If you experience these symptoms, it’s important to notify your healthcare provider immediately. Other serious issues include new or worsening hand tremors, severe diarrhea, and significant weight loss. Your healthcare provider might adjust your treatment or diet to help manage these effects.
References
- Zavesca (Miglustat) Product Monograph. South San Francisco, CA: Actelion Pharmaceuticals US, Inc.; 2020.
- Zavesca (Miglustat) Drug Label Information. South San Francisco, CA: Actelion Pharmaceuticals US, Inc.; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14545
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