Zepbound (tirzepatide)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Zepbound is a prescription medication that is used with diet and exercise for chronic weight management in adults who are obese or overweight with at least one comorbid condition related to weight (high blood pressure, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease).
Zepbound is available as a single-dose injectable pen in the following strengths:
- 2.5 mg/0.5 mL
- 5 mg/0.5 mL
- 7.5 mg/0.5 mL
- 10 mg/0.5 mL
- 12.5 mg/0.5 mL
- 15 mg/0.5 mL
Fact Table
Formula
C225H348N48O68
License
US DailyMed
Bioavailability
80%
Legal status
Prescription only
Chemical Name
Tirzepatide
Elimination half-life
5 days
Dosage (Strength)
-
Pregnancy
Consult Doctor
Brands
Zepbound
Protein binding
99%
PubChem CID
156588324
MedlinePlus
a622044
ChEBI
194186
ATC code
A10BX16
DrugBank
DB15171
KEGG
D11360
Routes of administration
Subcutaneous
Directions
Use Zepbound exactly as prescribed by your doctor. Tell your doctor or pharmacist if you have any questions or concerns.
Your doctor will tell you how much Zepbound to inject. Your healthcare provider will teach you how to properly inject Zepbound. The medication should be injected once weekly underneath the skin in the abdomen, thigh, or upper arm. Injection sites should be rotated with each dose.
Storage:
Zepbound should be stored in the refrigerator between 2°C and 8°C (36°F and 46°F) in the original carton. Do not freeze. The pens may be stored at 30°C (86°F) or below for up to 21 days. If the pens are stored at room temperature, do not return them to the refrigerator. Discard the medication if it has not been used within 21 days of removing it from the refrigerator.
All medications should be kept out of reach of children.
Ingredients
Tirzepatide, the ingredient in the type 2 diabetes medication Mounjaro®, is also the active ingredient in Zepbound.
Contraindications
Zepbound should not be used if you have a personal or family history of medullary thyroid carcinoma or if you have Multiple Endocrine Neoplasia syndrome type 2. In addition, if you have an allergy to tirzepatide or to any of the excipients in the medication, do not use Zepbound.
Cautions
Zepbound has the following FDA Boxed Warning:
- Tirzepatide has been shown to cause thyroid C-cell tumors in rats; however, it is not determined whether Zepbound causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans
- Patients with a personal or family history of MTC or patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should avoid using Zepbound. These patients should be counseled on the potential risk of MTC and symptoms of thyroid tumors
- Before you start treatment with Zepbound, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- The following can occur with Zepbound use:
- Gastrointestinal adverse reactions that may be severe. Zepbound has not been studied in patients with severe gastrointestinal disease; therefore, the medication is not recommended for use in these patients.
- Acute kidney injury
- Acute gallbladder disease
- Acute pancreatitis
- Hypersensitivity reactions, including anaphylaxis and angioedema (swelling). Patients should seek emergency care right away if they have any signs or symptoms of an allergic reaction.
- Using Zepbound with insulin products can increase the risk of low blood glucose levels, which may require a dose adjustment. Patients should be able to recognize signs of symptoms of low blood glucose and treat it as their doctor has instructed.
- Diabetic retinopathy complications in type 2 diabetic patients.
- Suicidal behavior and ideation. Zepbound should be stopped if patients experience symptoms.
- Harm to an unborn baby. Females who are taking oral contraceptives are recommended to switch to non-oral contraceptive methods or add a barrier method of contraception for 4 weeks after starting Zepbound and for 4 weeks after each dose increase.
Side Effects
Nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection site reactions, fatigue, hypersensitivity reactions, eructation, hair loss, and gastroesophageal reflux disease are common Zepbound side effects. However, other side effects may also occur. Contact your doctor right away if you have side effects that bother you or won’t go away.
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Reference:
- Zepbound. Indianapolis, IN: Lilly USA, LLC; 2023.
Frequently Asked Questions about Zepbound (Tirzepatide)
What is Zepbound, and what is it used for?
Zepbound is a medication recommended alongside dietary changes and physical activity for the long-term control of weight in adults who are either obese or overweight and have underlying health issues associated with their weight, including conditions like hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or heart disease.
How is Zepbound administered?
Zepbound is given through a single-dose injection pen, and your doctor will give you clear guidance on how much to use. You'll learn how to inject Zepbound just beneath your skin once a week. You can do the injection in your abdomen, thigh, or upper arm, and it's important to switch the injection spot each time.
How should I store Zepbound?
To store Zepbound correctly, keep it in its original box inside the refrigerator at temperatures between 2°C and 8°C (36°F and 46°F). Avoid freezing it. If needed, you can store the injection pens at temperatures up to 30°C (86°F) for a maximum of 21 days. Once they've been at room temperature, don't put them back in the fridge. If you haven't used the medication within 21 days of taking it out of the refrigerator, it should be thrown away. And as always, make sure to keep medications out of children's reach.
What are the active ingredients in Zepbound?
The active ingredient in Zepbound is tirzepatide, which is also used in the type 2 diabetes medication Mounjaro.
Are there any contraindications for using Zepbound?
You should avoid using Zepbound if you or a family member have a history of medullary thyroid carcinoma or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Additionally, avoid using Zepbound if you are allergic to Tirzepatide or any other ingredients in the medication.
What are the potential side effects of Zepbound?
Some common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection site reactions, fatigue, hypersensitivity reactions, eructation, hair loss, and gastroesophageal reflux disease. If you experience persistent or troublesome side effects, contact your doctor.
Can I use Zepbound while pregnant or breastfeeding?
Zepbound may pose risks to an unborn fetus, so it is crucial to inform your healthcare provider if you are pregnant or planning to become pregnant. If you are breastfeeding, discuss the potential risks and benefits with your doctor, as they will help you make an informed decision regarding the use of Zepbound.
What precautions should I take when using Zepbound alongside insulin products?
Using Zepbound in conjunction with insulin products may increase the risk of low blood glucose levels. Your healthcare provider will guide you on the appropriate dose adjustments if necessary. Make sure you can recognize the signs and symptoms of low blood glucose and follow your doctor's instructions for managing it.
Are there any specific recommendations for patients with severe gastrointestinal disease when considering Zepbound?
Zepbound is not recommended for patients with severe gastrointestinal disease because it has not been extensively studied in this population. If you have severe gastrointestinal issues, discuss alternative treatment options with your healthcare provider.
Can Zepbound cause harm to an unborn fetus or affect contraception methods?
Zepbound may potentially harm an unborn fetus. It is recommended that females taking contraceptives by mouth switch to non-oral contraceptives or add a barrier method for 4 weeks after starting Zepbound and for 4 weeks after each dose increase. If you have concerns about contraception while using Zepbound, consult with your healthcare provider to ensure appropriate measures are in place.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14463
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