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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Dovato

Sezzle
Brand

Dovato (Dolutegravir/Lamivudine)

Prescription Required

Strength

50/300mg

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  • Product Details

    Description

    Dovato (dolutegravir/lamivudine) is a combination drug product used to treat Human Immunodeficiency Virus (HIV).  It works by disrupting the virus’s ability to replicate. You can buy Dovato as a 50mg/300mg tablet. Store your Dovato tablets at room temperature. 

    Directions

    • You can take Dovato without regard to meals.
    • Dovato can be affected by foods and products that contain calcium, magnesium, iron, and aluminum. Take Dovato at least two hours before, or six hours after consuming any of the listed products.
    • If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, then skip the dose you missed and continue with your regular schedule.
    • Do not take two doses of Dovato at the same time.
    • The usual dose for Dovato is one tablet once per day.

    Ingredients

    • The active ingredients of Dovato are dolutegravir and lamivudine. Find a complete list of inactive ingredients in the package insert.
    Fact Table
    Formula C20H18F2N3NaO5, C8H11N3O3S
    License US FDA
    Routes of administration By mouth
    Legal status US: Rx Only
    Chemical Name Dolutegravir/Lamivudine
    Elimination half-life Dolutegravir: ~14 hr Lamivudine: 13-19 hr
    Dosage (Strength) 50/300mg
    Pregnancy Not classified yet
    Brands Dovato
    Protein binding Dolutegravir: ~99% Lamivudine: 36%
    PubChem CID 54726191, 60825
    MedlinePlus a619043
    ChEBI 76010, 63577
    ATC code J05AR25
    DrugBank DB08930, DB00709
    KEGG D11522
    Bioavailability -

    Cautions

    • Dovato has a black box warning that reads: PATIENTS CO-INFECTED WITH HEPATITIS B VIRUS (HBV) AND HUMAN IMMUNODEFICIENCY VIRUS (HIV-1): EMERGENCE OF LAMIVUDINE-RESISTANT HBV AND EXACERBATIONS OF HBV
    • Do not take Dovato if you are allergic to any of its ingredients.
    • Dovato can interact with other drugs. Talk to your doctor about any other medications you are taking before starting Dovato.
    • Do not take Dovato if you are currently using dofetilide. The reaction is potentially life-threatening.
    • If you have underlying liver disease, you could be a higher risk of severe adverse effects. Discuss your risk with your physician.
    • If you are pregnant or planning to become pregnant, discuss the risks of Dovato with your physician. Dovato could cause harm to a fetus in the first trimester of pregnancy.
    • Dovato can cause a condition called Immune Reconstitution Syndrome. Discuss the risk with your physician.

    Side Effects

    Dovato side effects include:

    • Severe Effects:
      • Lactic acidosis
      • Hepatitis Exacerbation
      • Hepatotoxicity
      • Injury of the liver
      • Immune Reconstitution Syndrome
      • Hypersensitivity Reaction
    • Common Effects:
      • Nausea
      • Diarrhea
      • Headache
      • Insomnia
      • Fatigue

    Other Considerations

    • Compare the Dovato price at Canada Pharmacy to your local drug store.

    References:

    1. Immune reconstitution inflammatory syndrome. (2019). Retrieved March 22, 2020
    2. Dovato. (n.d.). Retrieved March 21, 2020, from 
    3. DailyMed - DOVATO- DOLUTEGRAVIR sodium and lamivudine TABLET, film coated. (2019). Retrieved March 21, 2020


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13261

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