Description
Lipofen is a prescription drug that your doctor might give you to treat high cholesterol. It is usually used to treat a specific type of cholesterol called triglycerides. High triglycerides are a major risk factor for pancreatitis and heart disease.
Lipofen works by attaching to the nuclear transcription factor peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Attaching to this transcription factor prevents the formation of certain types of cholesterol. Since Lipofen has not been linked to a reduction in fatal heart disease, it should not be given as the only treatment for high cholesterol.
Fact Table |
Formula |
C20H21ClO4 |
License |
US FDA, EU EMA |
Bioavailability |
- |
Legal status |
Rx-only |
Chemical Name |
Fenofibrate |
Elimination half-life |
20h |
Dosage (Strength) |
50mg, 134mg, 150mg, 200mg |
Pregnancy |
No Known Risk |
Brands |
Fenoglide, Lipofen |
Protein binding |
99% |
PubChem CID |
3339 |
MedlinePlus |
a601052 |
ChEBI |
5001 |
ATC code |
C10AB05 |
DrugBank |
DB01039 |
KEGG |
D00565 |
Routes of administration |
By mouth |
Directions
Take 50-150 mg by mouth once daily as directed by your doctor. Lipofen should be taken with food.
Ingredients
The active ingredient in Lipofen is fenofibrate.
Interactions
The most common drug-drug interactions with this drug include:
- Acipimox
- Bile Acid Sequestrants
- Ciprofibrate
- Colchicine
- CycloSPORINE
- Ezetimibe
- Fosphenytoin-Phenytoin
- HMG-CoA Reductase Inhibitors
- Raltegravir
- Sulfonylureas
- Tacrolimus
- Vitamin K Antagonists
- Warfarin
Cautions
Tell your doctor if you have a history of kidney or liver problems before starting this drug.
Tell your doctor if you have a history of blood clots before starting this medication.
Use caution if you are also taking statin medications for the treatment of cholesterol because it can increase the risk of muscle disease.
Side Effects
Common side effects of this medication may include:
- Abdominal pain
- Acute generalized exanthematous pustulosis
- Acute kidney injury
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Arthralgia
- Asthenia
- Cholestatic hepatitis
- Constipation
- Decreased HDL cholesterol
- Diarrhea
- Dizziness
- Dyspepsia
- Headache
- Hepatic cirrhosis
- Hepatitis
- Hepatotoxicity
- Increased creatine phosphokinase
- Increased serum alanine aminotransferase
- Increased serum aspartate aminotransferase
- Increased serum bilirubin
- Increased serum creatinine
- Interstitial pulmonary disease
- Limb pain
- Muscle spasm
- Myalgia
- Myopathy
- Nasopharyngitis
- Pain
- Pancreatitis
- Pulmonary embolism
- Rhabdomyolysis
- Rhinitis
- Sinusitis
- Skin photosensitivity
- Skin rash
- Stevens-Johnson syndrome
- Thrombocytopenia
- Toxic epidermal necrolysis
- Upper respiratory tract infection
- Urticaria
References
Lipofen [package insert]. Juncos, Puerto Rico: Galephar Pharmaceutical Research Inc.; 2006.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1523