Gel-One (Hyaluronate)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details


    Gel-One Cross-Linked Hyaluronate is a sterile, transparent, and viscoelastic hydrogel injection used to treat knee pain caused by osteoarthritis in patients who did not respond well to other therapies, non-steroidal anti-inflammatory drugs (NSAIDs), or simple pain relievers.

    Fact Table




    US FDA



    Legal status


    Chemical Name


    Elimination half-life

    17 hours to 1.5 days

    Dosage (Strength)



    No Known Risk



    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    Gel-One is available in a pre-filled 3 mL syringe (1% solution, 30 mg total cross-linked hyaluronate) as a single-use injection into the intra-articular space of the knee. 

    Once the packaging is opened, the contents of the syringe must be used right away. Any unused Gel-One should be disposed of. 

    If you have any questions, ask your doctor or pharmacist.


    Each 3 mL syringe contains 1% (10 mg/mL) hyaluronan solution. 


    Do not use Gel-One if you are allergic to sodium hyaluronate or other ingredients in Gel-One.

    Do not use Gel-One if you have a skin disease or infection at or near the injection site.


    • Before you start treatment with Gel-One, tell your doctor:
      • If you have any allergies
      • About any medications you take. These include all prescription and over-the-counter medications, including vitamins and herbal supplements.
      • If you have any health conditions
      • If you are pregnant or plan to become pregnant
      • If you are currently breastfeeding or plan to breastfeed
    • Gel-One should be administered following strict aseptic technique
    • Gel-One should not be used with disinfectants that contain quaternary ammonium salts for the skin. This can lead to the precipitation of sodium hyaluronate. 
    • Gel-One should not be injected into a vessel.
    • Gel-One should not be injected outside of the joint or into the synovial tissue and capsule. 
    • Gel-One should be stored below 77°F (25° C). Do not store it in the freezer.
    • Joint pain, swelling, and/or effusion may occur after injecting Gel-One. These typically go away on their own or with conservative treatment.
    • Wait at least 48 hours before participating in strenuous activities.

    Side Effects

    The most common side effects associated with Gel-One injections include swelling, effusion, and stiffness of the joint. Contact your doctor right away if you develop side effects that bother you or won't go away.


    Gel-One Package Insert.

    Frequently Asked Questions about Gel-One (Hyaluronic Acid Injection)

    What is Gel-One?

    Gel-One is a brand of hyaluronic acid injection used to treat knee pain caused by osteoarthritis (OA). OA is a common joint condition that causes cartilage breakdown and inflammation, leading to pain, stiffness, and difficulty moving.

    How does Gel-One work?

    Hyaluronic acid is a naturally occurring substance found in joint fluid. It acts as a lubricant and shock absorber, cushioning the joint and reducing friction. Gel-One injections replenish hyaluronic acid in the knee joint, providing pain relief and improving joint function.

    Who is a good candidate for Gel-One?

    Gel-One is suitable for adults with mild to moderate knee OA who haven't found relief from other treatments like pain relievers, physical therapy, or corticosteroid injections.

    How is Gel-One administered?

    Gel-One is injected directly into the knee joint by a healthcare professional. The injection usually takes only a few minutes.

    What are the side effects of Gel-One?

    The most common side effects of Gel-One are injection site pain, redness, and swelling. These side effects are usually mild and temporary. More serious side effects, like infections, are rare.

    How long does Gel-One pain relief last?

    The pain relief from Gel-One can last for several months. Some people may need repeat injections to maintain pain relief.

    Are there any risks associated with Gel-One?

    Gel-One is generally safe, but like any injection, there is a small risk of infection. People with certain skin conditions or allergies should not receive Gel-One.

    Is Gel-One covered by insurance?

    Gel-One is covered by some insurance plans. It's important to check with your insurance provider to see if your plan covers Gel-One injections.

    What are the alternatives to Gel-One?

    There are several other treatments for knee OA, including pain relievers, physical therapy, corticosteroid injections, and surgery. Your doctor will discuss the best treatment options for you based on your individual condition.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13581

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