What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
GlucaGen HypoKit (Glucagon)
Prescription Required
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Product Details
Description
Glucagon for Injection is used to treat severe low blood sugar in adults and pediatric patients who have diabetes. It's also used to temporarily stop gastrointestinal tract movement in adults during radiologic examinations.
Fact Table
Formula
C153H225N43O49S
License
US DailyMed, EU EMA
Bioavailability
significantly lower
Legal status
Rx-Only
Chemical Name
Glucagon
Elimination half-life
26 minutes
Dosage (Strength)
One Kit
Pregnancy
Consult doctor
Brands
GlucaGen HypoKit
Protein binding
Not Available
PubChem CID
16132283
MedlinePlus
a682480
ChEBI
5391
ATC code
H04AA01
DrugBank
DB00040
KEGG
D00116
Routes of administration
Nasal, intravenous (IV), intramuscular injection (IM), subcutaneous injection
Directions
Follow the instructions that come with your Glucagon Kit prescription. Review the information with your family or caregivers. Talk to your doctor or pharmacist about any questions or concerns you may have regarding your prescription.
Glucagon Emergency Kits come with a single-dose vial of 1 mg Glucagon for Injection and a prefilled syringe that contains 1 mL of diluent for Glucagon.
One mL of diluent should be incorporated into the glucagon vial. Gently swirl the vial until the powder has dissolved and you don't see any particles. Inspect the vial to ensure that there are no particles or discoloration. The solution should appear clear. Do not use it if the solution appears cloudy or contains particulate matter. Draw up the appropriate dose of glucagon. Glucagon should be immediately injected subcutaneously, intramuscularly, or intravenously. Intravenous use should only be performed by a healthcare professional. After use, dispose of any unused medication.
Recommended dosage for treating severe low blood sugar in adults and pediatrics who weigh at least 20 kg: inject 1 mg (1 mL) subcutaneously or intramuscularly into the upper arm, thigh, or buttocks. While waiting to receive emergency care, another dose may be given if there is no response after 15 minutes.
Recommended dosage for pediatrics who weigh less than 20 kg: Inject 0.5 mg (0.5 mL) or dose equal to 20 mcg to 30 mcg per kg subcutaneously or intramuscularly into the upper arm, thigh, or buttocks. While waiting to receive emergency care, another dose may be given if there is no response after 15 minutes.
Glucagon for Injection should be stored at temperatures between 68°F-77°F (20°C-25°C).
Ingredients
Each Glucagon Emergency Kit comes with 1 mg Glucagon for Injection and a prefilled syringe containing 1 mL of diluent.
Contraindications
Do not use Glucagon if you have pheochromocytoma or insulinoma.
Do not use Glucagon if you are allergic to glucagon or any of its excipients.
Do not use Glucagon as a diagnostic aid if you have glucagonoma.
Cautions
- Before you receive a prescription for Glucagon, talk to your doctor about the following:
- Your allergies
- Your medications
- Drug interactions can occur with certain medications, including beta blockers, indomethacin, anticholinergic drugs, warfarin, and insulin. Ask your doctor if you are unsure whether or not you take these medications.
- Your health problems
- Your pregnancy or breastfeeding status
- Low blood sugar may occur in patients with insulinoma. Oral or intravenous glucose may be necessary.
- Glucagon may cause severe allergic reactions. Seek emergency care immediately if you develop a rash, trouble breathing, low blood pressure, or swelling of your face, lips, tongue, or throat.
- Glucagon may not work as well in patients who do not have enough glycogen present in their liver. Patients who are in starvation, have adrenal insufficiency, or have chronic low blood sugar may not have enough glycogen. Glucose may be the treatment of choice in these patients.
- Continuous administration of glucagon may cause a skin rash called necrolytic migratory erythema. This condition goes away once glucagon is stopped.
- Glucagon as a diagnostic aid may cause high blood sugar in patients with diabetes.
- Glucagon as a diagnostic aid may cause high blood pressure and rapid heart rate in patients with heart disease.
- Secondary low blood sugar may occur in patients with glucagonoma who use glucagon.
Side Effects
Tell your doctor if you experience bothersome or persistent side effects. Glucagon for Injection can cause side effects including reactions at the injection site, nausea, vomiting, headache, dizziness, weakness, paleness of the skin, diarrhea, drowsiness, and low blood pressure.
Reference:
Glucagon for Injection, for subcutaneous, intramuscular, or intravenous use. Indianapolis, IN: Lilly USA, LLC; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 56
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