What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Advil (Ibuprofen)
Also Known as Motrin
Prescription Required
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Product Details
Description
Advil is a common over-the-counter (OTC) pain medication used to treat various conditions, including rheumatoid arthritis and osteoarthritis, dysmenorrhea, and mild to moderate pain.
Advil is a non-steroidal anti-inflammatory drug (NSAID). It works by inhibiting the formation of prostaglandins, which are a type of signal molecule used by various cells of the body.
Fact Table
Formula
C13H18O2
License
US FDA, EU EMA
Bioavailability
80–100%
Legal status
US: OTC / Rx-only
Chemical Name
Ibuprofen
Elimination half-life
2–4 h
Dosage (Strength)
200mg, 300mg, 400mg
Pregnancy
Not recommended
Brands
Advil, Motrin
Protein binding
98%
PubChem CID
3672
MedlinePlus
a682159
ChEBI
5855
ATC code
C01EB16
DrugBank
DB01050
KEGG
D00126
Routes of administration
By mouth
Directions
The usual OTC dose for Advil is 200 mg tablets. The 400 mg and 800 mg tablets are prescription-only.
Do not take more than 3200 mg of Advil per day unless directed otherwise by your physician.
The usual Advil dosage is 1-2 tablets by mouth every four to six hours as needed for pain. Advil and other NSAIDs should be taken with food.
Advil should be used at the lowest effective dose for the shortest period.
Ingredients
The active ingredient in Advil is ibuprofen.
Interactions
Common drug-drug interactions with Advil may include:
- Aminolevulinic Acid
- Apixaban
- Aspirin
- Citalopram
- Cyclosporine
- Dabigatran
- Edoxaban
- Enoxaparin
- Fluoxetine
- Heparin
- Imatinib
- Ketorolac
- Lithium
- Loop diuretics
- Methotrexate
- Naproxen
- Paroxetine
- Pemetrexed
- Rivaroxaban
- Sertraline
- Sodium phosphates
- Tenofovir
- Urokinase
- Warfarin
Tell your doctor and pharmacist about all medications you are taking before starting Advil.Cautions
Advil can increase the risk of serious cardiovascular events like fatal heart attack and stroke. The risk is higher the longer Advil is used.
Advil and other NSAIDs increase the risk of stomach ulcers and other gastrointestinal side effects.
Ask your doctor and pharmacist for a full list of precautions.
Side Effects
Common side effects with Advil may include:
- Abdominal cramps
- Abdominal distress
- Abdominal pain
- Anemia
- Bloating
- Constipation
- Decreased appetite
- Decreased hemoglobin
- Diarrhea
- Dizziness
- Dyspepsia
- Edema
- Epigastric pain
- Flatulence
- Fluid retention
- Headache
- Heartburn
- Increased liver enzymes
- Maculopapular rash
- Nausea
- Nervousness
- Prolonged bleed time
- Pruritus
- Renal function abnormality
- Skin rash
- Tinnitus
- Vomiting
References
- Advil [package insert]. Livonia, MI: Major Pharmaceuticals; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1566
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