Description
NovoLog (Insulin Aspart) is a rapid-acting human insulin analog used to manage blood glucose levels in individuals with type 1 or type 2 diabetes mellitus. It is engineered to begin working within 10 to 20 minutes after subcutaneous administration, with a peak action around 1 to 3 hours and duration of effect lasting 3 to 5 hours. NovoLog is structurally modified to allow faster absorption than regular human insulin, making it suitable for mealtime glucose control. It is commonly used in combination with intermediate- or long-acting insulin to maintain basal insulin coverage.
| Fact Table |
| Formula | C256H381N65O79S6 |
| License | US FDA, EMA |
| Bioavailability | ~60% |
| Legal status | Prescription only (Rx) |
| Chemical Name | Insulin Aspart |
| Elimination half-life | ~81 minutes |
| Dosage (Strength) | 100 units/mL (U-100) |
| Pregnancy | Category B – No evidence of risk in humans |
| Brands | NovoLog, Fiasp |
| Protein binding | Low |
| PubChem CID | 16129680 |
| MedlinePlus | a600027 |
| ChEBI | 70799 |
| ATC code | A10AB05 |
| DrugBank | DB01307 |
| KEGG | D07708 |
| Routes of administration | Subcutaneous injection, intravenous (in emergencies) |
Directions
NovoLog should be administered subcutaneously immediately before a meal (within 5–10 minutes) or after meal onset when needed. Dosage must be individualized based on clinical monitoring and patient-specific factors including carbohydrate intake, physical activity, and current blood glucose levels. It can be injected into the abdomen, thigh, upper arm, or buttocks, with routine rotation of sites to reduce the risk of lipodystrophy. NovoLog is also compatible with insulin pumps and may be administered intravenously in controlled clinical environments.
Ingredients
Active ingredient: Insulin Aspart (rDNA origin) 100 units/mL. Inactive ingredients: glycerol, phenol, metacresol, zinc, disodium phosphate dihydrate, sodium chloride, and water for injection. The formulation may also include hydrochloric acid or sodium hydroxide to adjust pH.
Contraindications
NovoLog is contraindicated in patients experiencing hypoglycemia and in those with hypersensitivity to insulin aspart or any component of the formulation. It should not be used during episodes of low blood sugar or in the presence of insulin pump malfunction.
Cautions
Dose adjustments may be required when changing insulin types, regimens, or routes of administration. Monitor blood glucose closely during transitions. Caution is advised in patients with renal or hepatic impairment, during periods of stress, infection, or surgery, and in those consuming alcohol, as these factors can affect insulin sensitivity and glucose metabolism. Improper storage or handling may reduce the efficacy of the medication.
Side Effects
Common side effects may include:
- Hypoglycemia (most frequent)
- Injection site reactions (pain, redness, swelling)
- Lipodystrophy (lipoatrophy or lipohypertrophy)
- Weight gain
- Hypokalemia
- Peripheral edema
Serious allergic reactions such as anaphylaxis are rare but possible and require immediate medical attention.
Frequently Asked Questions about Novolog (Insulin Aspart)
What is Novolog (Insulin Aspart)?
Novolog is a rapid-acting insulin analog used to control blood sugar spikes that occur after eating. It is typically used in people with type 1 or type 2 diabetes.
When should I take Novolog?
Novolog should be taken 5 to 10 minutes before a meal. This timing helps manage the rise in blood glucose that occurs after eating.
How fast does Novolog work, and how long does it last?
Novolog starts working in about 10–20 minutes, peaks in 1–3 hours, and lasts up to 3–5 hours.
How is Novolog different from long-acting insulin?
Novolog is rapid-acting, meant for mealtime glucose control, while long-acting insulins like Lantus or Tresiba provide basal coverage throughout the day and night.
Can Novolog be used in an insulin pump?
Yes. Novolog is approved for use in insulin pumps (CSII) for continuous and bolus insulin delivery.
What are the common side effects of Novolog?
Common side effects include:
Low blood sugar (hypoglycemia)
Injection site reactions (redness, swelling)
Weight gain
Rarely, allergic reactions or lipodystrophy at injection sites
Can I use Novolog in combination with other insulins?
Yes. Novolog is often used alongside a long-acting insulin like Lantus or Levemir to provide both mealtime and background insulin coverage.
How should Novolog be stored?
Unopened: Store in the refrigerator (36°F–46°F / 2°C–8°C)
In use: Store at room temperature (below 86°F / 30°C) for up to 28 days
Do not freeze or expose to direct sunlight.
Is Novolog available in different delivery forms?
Yes. Novolog is available in:
Vials for use with syringes
FlexPen (prefilled pen)
PenFill cartridges
Insulin pumps (with appropriate pump compatibility)
Can Novolog be used in children?
Yes. Novolog is approved for use in children 2 years and older with type 1 diabetes. Pediatric doses are carefully adjusted based on weight, age, and insulin sensitivity.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 2407
Prescription Required