Description
Pletal (cilostazol) is classified as a phosphodiesterase III inhibitor (PDE III inhibitor) used to reduce the symptoms of intermittent claudication, as demonstrated by an increased walking distance.
Pletal is available in 50 mg and 100 mg tablets.
Fact Table |
Formula |
C20H27N5O2 |
License |
US DailyMed |
Bioavailability |
90% |
Legal status |
Rx-Only |
Chemical Name |
Cilostazol |
Elimination half-life |
11–13 hours |
Dosage (Strength) |
50mg, 100mg |
Pregnancy |
contraindicated |
Brands |
Pletal |
Protein binding |
95–98% |
PubChem CID |
2754 |
MedlinePlus |
a601038 |
ChEBI |
31401 |
ATC code |
B01AC23 |
DrugBank |
DB01166 |
KEGG |
D01896 |
Routes of administration |
By mouth (tablets) |
Directions
The recommended dosage is 100 mg by mouth twice daily. Take 30 minutes before or two hours after breakfast and dinner.
The dosage may be 50 mg by mouth twice daily when taken with certain medications such as ketoconazole, itraconazole, erythromycin, diltiazem, ticlopidine, fluconazole, and omeprazole.
Ingredients
Each tablet contains the active ingredient, Cilostazol.
Contraindications
Do not take Pletal if you have heart failure.
Do not take Pletal if you are allergic to cilostazol or any of the other ingredients in Pletal. Be sure to discuss your allergies with your doctor.
Cautions
WARNING: CONTRAINDICATED IN HEART FAILURE PATIENTS
See full prescribing information for complete boxed warning.
PLETAL is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with the pharmacologic effect have caused decreased survival compared to placebo patients with class III-IV heart failure.
Tell your doctor if you have heart problems. Pletal may increase your heart rate or cause palpitations or low blood pressure.
Left ventricular outflow tract obstruction has been reported in some patients who received Pletal. Once you are prescribed and buy Pletal, then you should be monitored for a new murmur or heart symptoms after starting Pletal.
Pletal may cause low blood counts.
Pletal may cause hemostatic disorders or bleeding and should not be used in these patients.
Tell your doctor about any medications you are taking, including prescription and over-the-counter medications.
Your doctor should know if you are pregnant or plan to become pregnant and if you are breastfeeding or plan to breastfeed.
Side Effects
Pletal may cause side effects, including:
- Abdominal pain
- Abnormal stools
- Diarrhea
- Dizziness
- Headache
- Increased heart rate
- Indigestion
- Infection
- Palpitation
- Pharyngitis
- Swelling of your legs or hands
Tell your doctor right away if you experience any side effects while taking Pletal.
Reference:
Pletal Prescribing Information. Rockville, MD: Otsuka America Pharmaceutical, Inc.; 2015.
About Dr. Savannah Muncy (Page Author)
Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 2595