What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Pletal (Cilostazol)
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Product Details
Description
Pletal (cilostazol) is classified as a phosphodiesterase III inhibitor (PDE III inhibitor) used to reduce the symptoms of intermittent claudication, as demonstrated by an increased walking distance.
Pletal is available in 50 mg and 100 mg tablets.
Fact Table
Formula
C20H27N5O2
License
US DailyMed
Bioavailability
90%
Legal status
Rx-Only
Chemical Name
Cilostazol
Elimination half-life
11–13 hours
Dosage (Strength)
50mg, 100mg
Pregnancy
contraindicated
Brands
Pletal
Protein binding
95–98%
PubChem CID
2754
MedlinePlus
a601038
ChEBI
31401
ATC code
B01AC23
DrugBank
DB01166
KEGG
D01896
Routes of administration
By mouth (tablets)
Directions
The recommended dosage is 100 mg by mouth twice daily. Take 30 minutes before or two hours after breakfast and dinner.
The dosage may be 50 mg by mouth twice daily when taken with certain medications such as ketoconazole, itraconazole, erythromycin, diltiazem, ticlopidine, fluconazole, and omeprazole.
Ingredients
Each tablet contains the active ingredient, Cilostazol.
Contraindications
Do not take Pletal if you have heart failure.
Do not take Pletal if you are allergic to cilostazol or any of the other ingredients in Pletal. Be sure to discuss your allergies with your doctor.
Cautions
WARNING: CONTRAINDICATED IN HEART FAILURE PATIENTS
See full prescribing information for complete boxed warning.
PLETAL is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with the pharmacologic effect have caused decreased survival compared to placebo patients with class III-IV heart failure.
Tell your doctor if you have heart problems. Pletal may increase your heart rate or cause palpitations or low blood pressure.
Left ventricular outflow tract obstruction has been reported in some patients who received Pletal. Once you are prescribed and buy Pletal, then you should be monitored for a new murmur or heart symptoms after starting Pletal.
Pletal may cause low blood counts.
Pletal may cause hemostatic disorders or bleeding and should not be used in these patients.
Tell your doctor about any medications you are taking, including prescription and over-the-counter medications.
Your doctor should know if you are pregnant or plan to become pregnant and if you are breastfeeding or plan to breastfeed.
Side Effects
Pletal may cause side effects, including:
- Abdominal pain
- Abnormal stools
- Diarrhea
- Dizziness
- Headache
- Increased heart rate
- Indigestion
- Infection
- Palpitation
- Pharyngitis
- Swelling of your legs or hands
Tell your doctor right away if you experience any side effects while taking Pletal.Reference:
Pletal Prescribing Information. Rockville, MD: Otsuka America Pharmaceutical, Inc.; 2015.
Frequently Asked Questions about Pletal (Cilostazol)
What is Pletal (Cilostazol) used for?
Pletal is used to improve symptoms of intermittent claudication, a condition causing leg pain and cramping during activity that eases with rest. It helps you walk further without pain.
How does Pletal work?
Pletal works by improving blood flow in the legs by preventing blood clots and widening blood vessels. This increases oxygen supply to muscles, reducing pain.
What is the dosage of Pletal?
The typical dose is 100mg twice daily, 30 minutes before or 2 hours after meals. Your doctor may adjust the dosage based on your individual needs and medical history.
What are the side effects of Pletal?
Common side effects include headache, diarrhea, dizziness, flushing, and leg cramps. More serious side effects are rare, but include bleeding, heart problems, and liver damage.
Who should not take Pletal?
Pletal is not recommended for people with heart failure, severe liver or kidney disease, uncontrolled bleeding problems, or allergies to cilostazol or its ingredients.
Can I take Pletal with other medications?
Pletal can interact with certain medications, including other blood thinners, anti-platelet drugs, and some antibiotics. Inform your doctor about all medications you take before starting Pletal.
How long does it take for Pletal to work?
Some improvement may be seen within 2 weeks, but it can take up to 12 weeks for the full effect. If symptoms haven't improved after 3 months, your doctor may need to adjust your treatment plan.
Does Pletal cure intermittent claudication?
No, Pletal does not cure the underlying cause of intermittent claudication, but it can effectively manage symptoms and improve walking ability.
Are there any lifestyle changes I can make to support Pletal's effectiveness?
Yes, quitting smoking, exercising regularly, maintaining a healthy weight, and managing other health conditions like diabetes can improve blood flow and enhance Pletal's benefits.
What should I do if I miss a dose of Pletal?
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not take a double dose.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2595
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