What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Accuretic (Quinapril/HCTZ)
Also Known as Accuzide Forte
Prescription Required
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Product Details
Description
Accuretic is made up of two medications: an angiotensin-converting enzyme inhibitor (ACE-I), quinapril, and a thiazide diuretic, hydrochlorothiazide (HCTZ). The Accuretic generic is quinapril HCl/hydrochlorothiazide. This combination drug is used to treat high blood pressure; however, it should not be used as initial therapy.
Accuretic oral tablets come in the following strengths:
- 10 mg quinapril/12.5 mg HCTZ
- 20 mg quinapril/12.5 mg HCTZ
- 20 mg quinapril/25 mg HCTZ
Fact Table
Formula
C25H30N2O5. HCl
License
US FDA
Bioavailability
70%
Legal status
Rx-Only
Chemical Name
Quinapril/HCTZ
Elimination half-life
6-15 hr
Dosage (Strength)
10/12.5mg, 20/12.5mg, 20/25mg
Pregnancy
Consult Doctor
Brands
Accuretic
Protein binding
97%
PubChem CID
54891
MedlinePlus
a692026
ChEBI
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ATC code
C09BA06
DrugBank
DB00881
KEGG
D10278
Routes of administration
By Mouth
Directions
Take Accuretic as your doctor has prescribed. If any questions or concerns arise, talk to your doctor or pharmacist.
The dose of Accuretic is generally 10 mg quinapril/12.5 mg hydrochlorothiazide to 80 mg quinapril/50 mg hydrochlorothiazide by mouth once daily.
Your doctor may adjust your dose depending on your tolerance and response to the medication.
Ingredients
Accuretic contains quinapril and hydrochlorothiazide.
Inactive ingredients include candelilla wax, crospovidone, hydroxypropyl cellulose, hypromellose, iron oxide red, iron oxide yellow, lactose, magnesium carbonate, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.
Contraindications
Do not take Accuretic if you are allergic to quinapril, hydrochlorothiazide, or any other ACE-I or if you've had angioedema (swelling underneath the skin) with other ACE-Is in the past.
Do not take Accuretic if you are allergic to sulfa medications or if your kidneys are not producing urine.
Do not take Accuretic with a neprilysin inhibitor like sacubitril. You should wait at least 36 hours of switching to or from sacubitril/valsartan before taking Accuretic.
Diabetic patients should not take Accuretic with aliskiren.
Cautions
There is a FDA Boxed Warning against the use of Accuretic during pregnancy as the drug can harm or cause death in a developing fetus.
- Before you begin treatment with Accuretic, talk to your doctor about:
- All the prescription and over-the-counter medications you take, as Accuretic can interact with certain medications, including lithium, dioxin, and nonsteroidal anti-inflammatory drugs (NSAIDs)
- Your allergies
- Your medical history and health problems
- Your pregnancy or breastfeeding status
- Accuretic may cause angioedema (swelling underneath the skin) of the face, legs, arms, lips, tongue, or throat. If this occurs, seek medical care immediately.
- Patients who undergo desensitizing treatment with Hymenoptera venom and are taking Accuretic may develop serious allergic reactions.
- Dialysis patients who are dialyzed with high-flux membranes and are taking Accuretic may develop serious allergic reactions.
- Although rare, Accuretic may cause serious liver problems that can be fatal. Seek medical care right away if you develop yellowing of the skin or whites of the eyes.
- Accuretic is used to treat high blood pressure, and therefore, can cause low blood pressure that may be symptomatic. Patients should monitor their blood pressure regularly.
- Accuretic can cause kidney problems.
- Rarely, Accuretic can cause abnormal white blood cell counts and depression of the bone marrow. Patients with kidney problems, lupus, or scleroderma may be at higher risk.
- Accuretic may worsen or cause lupus.
- Accuretic may cause acute-closure glaucoma. The risk is greater in patients with a sulfa or penicillin allergy.
- High or low potassium levels, low sodium levels, and low magnesium levels can occur with the use of Accuretic.
- Cholesterol, triglyceride, and uric acid levels can increase with the use of Accuretic.
- Accuretic can cause a nonproductive cough.
Side Effects
Accuretic can cause side effects such as cough, headache, dizziness, fatigue, muscle pain, nausea, vomiting, stomach pain, back pain, and diarrhea.
If you develop side effects that bother you or won't go away, contact your doctor immediately.
Reference:
- Accuretic (quinapril and hydrochlorothiazide) tablets. New York, NY: Parke-Davis Division of Pfizer, Inc; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1309
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