What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Aldactazide (spironolactone/HCTZ)


Aldactazide (spironolactone/HCTZ)

Prescription Required

25 / 25mg

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Generic Equivalent - Aldactazide (spironolactone/HCTZ)

Prescription Required


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  • Product Details


    What is Aldactazide?

    • Aldactazide (Spironolactone/Hydrochlorothiazide) is a combination medication used to treat high blood pressure, congestive heart failure, and cirrhosis of the liver.

    How does it work?

    • The medications contained in Aldactazide are diuretics that work in a complementary way. Spironolactone blocks the activity of aldosterone in your kidneys to increase your urine output. Hydrochlorothiazide promotes the excretion of sodium and water by preventing your kidneys from re-absorbing them.

    How is it supplied?

    • You can buy Aldactazide online at Canada Pharmacy in brand or generic form.
      • Brand name Aldactazide
        • 25mg/25mg tablets
      • Generic Spironolactone/Hydrochlorothiazide
        • 25mg/25mg tablets
        • 50mg/50mg tablets

    How should I store it?

    • Store your Aldactazide at room temperature and keep it out of reach of children.

    Fact Table


    C24H32O4S, C7H8ClN3O4S2


    US: FDA



    Legal status

    Rx Only

    Chemical Name

    Spironolactone/ Hydrochlorothiazide

    Elimination half-life

    1.4 hours, 5.6-14.8 hours

    Dosage (Strength)

    25mg, 50mg


    Risk not ruled out



    Protein binding

    less than 90%, 40-68%

    PubChem CID





    9241, 5778

    ATC code



    DB00421, DB00999



    Routes of administration

    By mouth


    Should I take Aldactazide with food?

    • You can take Aldactazide with or without food.
    • Avoid eating foods high in potassium while using Aldactazide.

    Are there any special instructions?

    • Take your Aldactazide tablets with a full glass of water.
    • Work closely with your doctor to achieve the best results.

    What is the usual dose?

    • The usual maintenance dose of Aldactazide is 50mg/50mg to 100mg/100mg per day.
      • Your doctor could adjust your dose up or down to help you get the best results.


    What is the active ingredient in Aldactazide?

    • Spironolactone
    • Hydrochlorothiazide

    What are the inactive ingredients?

    • For a complete list of inactive ingredients of Aldactazone, click here or check the product packaging.


    Who should avoid taking Aldactazide?

    • Do not use Aldactazide if you have a known allergy to any of the ingredients or sulfonamide derivatives.
    • Do not take Aldactazide if you have any of the following conditions:
      • Anuria
      • Acute renal insufficiency
      • Significant kidney impairment
      • Hypercalcemia
      • Hyperkalemia
      • Addison's disease
      • Acute severe liver failure

    What are the risks?

    • If you are pregnant, breastfeeding, or considering becoming pregnant, talk to your doctor about the risks of using Aldactazide.
    • Aldactazide can cause an increase in potassium levels. Additional potassium supplementation should be avoided.
    • Hydrochlorothiazide could activate or worsen your lupus erythematosus. Discuss your risk with your doctor.
    • Hydrochlorothiazide can cause acute transient myopia and acute angle-closure glaucoma.

    Side Effects

    What are the potential side effects of Aldactazide?

    • Weakness
    • Low blood pressure
    • Pancreatitis
    • Jaundice
    • Diarrhea
    • Vomiting
    • Sialoadenitis
    • Cramping
    • Constipation
    • Gastric irritation
    • Nausea
    • Anorexia
    • Acute myopia
    • Acute angle-closure glaucoma
    • Aplastic anemia
    • Agranulocytosis
    • Leukopenia
    • Hemolytic anemia
    • Thrombocytopenia
    • Necrotizing angiitis
    • Respiratory distress
    • Photosensitivity
    • Fever
    • Urticaria
    • Rash
    • Purpura
    • Electrolyte imbalance
    • Hyperglycemia
    • Glycosuria
    • Hyperuricemia
    • Muscle spasm
    • Vertigo
    • Paresthesia
    • Dizziness
    • Headache
    • Restlessness
    • Renal failure
    • Interstitial nephritis
    • Renal dysfunction
    • Erythema multiforme
    • Transient blurred vision
    • Xanthopsia
    • Gastric bleeding
    • Ulceration
    • Gynecomastia
    • Sexual difficulties
    • Menstrual abnormalities
    • Breast pain
    • Carcinoma of the breast
    • Vasculitis
    • Leg cramps
    • Lethargy
    • Confusion
    • Ataxia
    • Liver toxicity
    • Stevens-Johnson Syndrome
    • Toxic epidermal necrolysis
    • Alopecia


    Other Considerations

    • Compare our Aldactazide price with your local drug store.
    • Aldactazide is also sometimes called "Aldactazide 25 25".


    1. DailyMed - ALDACTAZIDE- SPIRONOLACTONE and hydrochlorothiazide TABLET, film coated. (2020). Retrieved May 22, 2020.
    2. Aldactazide drug interactions. (n.d.). Retrieved May 22, 2020.

    Frequently Asked Questions about Aldactazide

    What is Aldactazide?

    Aldactazide is a medication that combines two active ingredients, spironolactone and hydrochlorothiazide (HCTZ). It is commonly used to treat high blood pressure and conditions involving excess fluid retention, such as heart failure and edema.

    How does Aldactazide work?

    Spironolactone works as a potassium-sparing diuretic, helping the kidneys remove excess salt and water from the body while retaining potassium. Hydrochlorothiazide is a thiazide diuretic that also helps the body eliminate excess salt and water. The combination of these two drugs helps lower blood pressure and reduce edema.

    What is the typical dosage of Aldactazide?

    The recommended dosage of Aldactazide can vary depending on your medical condition and your healthcare provider's instructions. It is important to follow your doctor's prescribed dosage and not exceed it.

    Can Aldactazide cause side effects?

    Yes, like any medication, Aldactazide can cause side effects. Common side effects may include dizziness, headache, stomach upset, and increased urination. More serious side effects may include electrolyte imbalances, kidney problems, and allergic reactions. If you experience any unusual or severe side effects, consult your healthcare provider.

    Can Aldactazide be used during pregnancy or while breastfeeding?

    It is important to discuss the use of Aldactazide with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Spironolactone can have specific considerations during pregnancy, so your doctor will weigh the potential benefits and risks.

    Are there any drug interactions with Aldactazide?

    Yes, Aldactazide can interact with other medications, including certain diuretics, ACE inhibitors, and potassium supplements. Inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.

    How should I take Aldactazide?

    Follow your doctor's instructions carefully. Typically, Aldactazide is taken orally with or without food. It's essential to take it at the same time each day and not miss any doses. Do not stop taking the medication abruptly without consulting your healthcare provider.

    Can Aldactazide be used to treat conditions other than high blood pressure and edema?

    Aldactazide is primarily prescribed for high blood pressure and conditions involving fluid retention. Its use for other conditions should be discussed with your doctor.

    How long does it take for Aldactazide to start working?

    The time it takes for Aldactazide to start working can vary from person to person and depends on the specific condition being treated. It's essential to continue taking the medication as prescribed even if you do not notice immediate effects.

    What should I do if I miss a dose of Aldactazide?

    If you miss a dose, take it as soon as you remember. However, if it's close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1324

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