What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Loprox (Ciclopirox)
Also Known as Nibulen
Prescription Required
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Product Details
Description
LOPROX (ciclopirox) is a prescription medication that is used for fungal infections. It is effective against different types of fungal species and can be made into a lotion or a cream.
- Onychomycosis of the fingernails and toenails
- Seborrheic dermatitis
- Tinea cruris
- Tinea corporis
- Tinea pedis
When applied to the skin, LOPROX works by preventing fungal cells from dividing. It interferes with critical molecules in fungal cells like DNA, RNA, and protein. LOPROX may take several weeks to start working and should be continued for at least four weeks.
Fact Table
Formula
C12H17NO2
License
US FDA
Bioavailability
Less than 5%
Legal status
Rx-only
Chemical Name
Ciclopirox
Elimination half-life
1.7 hours
Dosage (Strength)
1%
Pregnancy
No Known Risks
Brands
Loprox
Protein binding
94 to 97%
PubChem CID
2749
MedlinePlus
a604021
ChEBI
453011
ATC code
D01AE14
DrugBank
DB01188
KEGG
D03488
Routes of administration
Topical
Directions
The normal instructions for LOPROX are to apply to the affected area(s) of the skin twice daily. Apply to a clean and dry area of the skin. Wash hands thoroughly after application. Do not get LOPROX into the eyes, mouth, or onto the genitals.
Use LOPROX exactly as prescribed.
Ingredients
The active ingredient in LOPROX is ciclopirox.
Interactions
There are no known drug-drug interactions with LOPROX since it is not absorbed into the bloodstream.
Cautions
If irritation or redness develops, stop taking LOPROX and tell your doctor.
Certain formulations of LOPROX may contain benzoyl peroxide. Large amounts have been associated with gasping syndrome in neonates.
Side Effects
Common LOPROX cream side effects may include:
- Acne vulgaris
- Alopecia
- Application site burning
- contact dermatitis
- Erythema
- Facial edema
- Hair discoloration (shampoo only)
- Headache
- Local irritation
- Local pain
- Localized erythema
- Nail disease
- Ventricular tachycardia (shampoo only)
References
Loprox [package insert]. Scottsdale, AZ: Medicis; 2013.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1615
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