Description
Lotensin is a drug used to treat hypertension, the medical term for high blood pressure. High blood pressure is commonly called ";the silent killer" because it can go undetected for many years and is a leading cause of heart disease worldwide.
When the blood pressure is too high, too much force is acting on the blood vessels' walls. The excess force causes small tears in blood vessel walls and organ damage. A person with high blood pressure for a long period has a much greater risk of heart attack and stroke.
Fact Table |
Formula |
C24H28N2O5 |
License |
US FDA |
Bioavailability |
37% |
Legal status |
Rx-Only |
Chemical Name |
Benazepril |
Elimination half-life |
10-11 hours |
Dosage (Strength) |
5mg, 10mg, 20mg, 40mg |
Pregnancy |
Consult Doctor |
Brands |
Lotensin |
Protein binding |
96.7% |
PubChem CID |
5362124 |
MedlinePlus |
a692011 |
ChEBI |
3011 |
ATC code |
C09AA07 |
DrugBank |
DB00542 |
KEGG |
- |
Routes of administration |
Oral
|
Directions
Take Lotensin exactly as instructed by your doctor. The normal dosage is 10-40 mg by mouth once daily. The dose may be divided twice daily.
Ingredients
The active ingredient in Lotensin is benazepril.
Interactions
Tell your doctor if you are taking any of the following before starting Lotensin:
- Bromperidol
- Grass Pollen Allergen Extract
- Sacubitril
- Aliskiren
- Amifostine
- Angiotensin II Receptor Blockers
- Lanthanum
- Lithium
- Obinutuzumab
- Sodium Phosphates
- Urapidil
If you are taking these medications, you may need to switch to an alternative before starting Lotensin.
Cautions
Tell your doctor if you have a history of kidney or liver disease.
Stop taking Lotensin if you develop a sudden, unexplained dry cough. You may need to be switched to another medication.
Side Effects
Common adverse reactions to this drug include
- Agranulocytosis
- Alopecia
- Angioedema
- Anxiety
- Arthralgia
- Arthritis
- Asthenia
- Asthma
- Bronchitis
- Cholestatic Hepatitis
- Constipation
- Cough
- Decreased Libido
- Diaphoresis
- Dizziness
- Drowsiness
- Dyspnea
- ECG Changes
- Eosinophilia
- Fatigue
- Flushing
- Gastritis
- Headache
- Hemolytic Anemia
- Hypertonia
- Hyponatremia
- Hypotension
- Impotence
- Increased Liver Enzymes
- Increased Serum Bilirubin
- Increased Serum Glucose
- Increased Uric Acid
- Infection
- Insomnia
- Melena
- Myalgia
- Nausea
- Nervousness
- Orthostatic Dizziness
- Pancreatitis
- Paresthesia
- Pemphigus
- Proteinuria
- Psoriasis
- Sinusitis
- Skin Photosensitivity
- Stevens-Johnson Syndrome
- Thrombocytopenia
- Urinary Frequency
- Urinary Tract Infection
- Vomiting
References
Lotensin [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2009.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1617