What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lotensin (Benazepril HCl)
Prescription Required
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Product Details
Description
Lotensin is a drug used to treat hypertension, the medical term for high blood pressure. High blood pressure is commonly called ";the silent killer" because it can go undetected for many years and is a leading cause of heart disease worldwide.
When the blood pressure is too high, too much force is acting on the blood vessels' walls. The excess force causes small tears in blood vessel walls and organ damage. A person with high blood pressure for a long period has a much greater risk of heart attack and stroke.
Fact Table
Formula
C24H28N2O5
License
US FDA
Bioavailability
37%
Legal status
Rx-Only
Chemical Name
Benazepril
Elimination half-life
10-11 hours
Dosage (Strength)
5mg, 10mg, 20mg, 40mg
Pregnancy
Consult Doctor
Brands
Lotensin
Protein binding
96.7%
PubChem CID
5362124
MedlinePlus
a692011
ChEBI
3011
ATC code
C09AA07
DrugBank
DB00542
KEGG
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Routes of administration
Oral
Directions
Take Lotensin exactly as instructed by your doctor. The normal dosage is 10-40 mg by mouth once daily. The dose may be divided twice daily.
Ingredients
The active ingredient in Lotensin is benazepril.
Interactions
Tell your doctor if you are taking any of the following before starting Lotensin:
- Bromperidol
- Grass Pollen Allergen Extract
- Sacubitril
- Aliskiren
- Amifostine
- Angiotensin II Receptor Blockers
- Lanthanum
- Lithium
- Obinutuzumab
- Sodium Phosphates
- Urapidil
If you are taking these medications, you may need to switch to an alternative before starting Lotensin.Cautions
Tell your doctor if you have a history of kidney or liver disease.
Stop taking Lotensin if you develop a sudden, unexplained dry cough. You may need to be switched to another medication.
Side Effects
Common adverse reactions to this drug include
- Agranulocytosis
- Alopecia
- Angioedema
- Anxiety
- Arthralgia
- Arthritis
- Asthenia
- Asthma
- Bronchitis
- Cholestatic Hepatitis
- Constipation
- Cough
- Decreased Libido
- Diaphoresis
- Dizziness
- Drowsiness
- Dyspnea
- ECG Changes
- Eosinophilia
- Fatigue
- Flushing
- Gastritis
- Headache
- Hemolytic Anemia
- Hypertonia
- Hyponatremia
- Hypotension
- Impotence
- Increased Liver Enzymes
- Increased Serum Bilirubin
- Increased Serum Glucose
- Increased Uric Acid
- Infection
- Insomnia
- Melena
- Myalgia
- Nausea
- Nervousness
- Orthostatic Dizziness
- Pancreatitis
- Paresthesia
- Pemphigus
- Proteinuria
- Psoriasis
- Sinusitis
- Skin Photosensitivity
- Stevens-Johnson Syndrome
- Thrombocytopenia
- Urinary Frequency
- Urinary Tract Infection
- Vomiting
References
Lotensin [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2009.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1617
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