What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Motegrity (Prucalopride)

Also Known as Resotran


Motegrity (Prucalopride)

Prescription Required


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Generic Equivalent - Motegrity (Prucalopride)

Prescription Required


You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details


    Motegrity is a prescription prokinetic medication used for the treatment of chronic idiopathic constipation CIC. Motegrity works to increase the movement of the colon muscle (peristalsis) to make bowel movements easier. The active ingredient Prucalopride targets a specific receptor in the colon to enhance the body's natural peristalsis process of waste elimination from the colon. You can buy Motegrity medication with a prescription at most pharmacies, and you may find your Motegrity cost is lower if you order your medication online from Canada.

    Fact Table




    US FDA


    Over 90%

    Legal status


    Chemical Name


    Elimination half-life

    18-20 hours

    Dosage (Strength)

    1mg, 2mg


    Not Recommended



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth (Tablets)


    Take 1 Motegrity tablet once a day, with a meal or on its own.


    The active ingredient in Motegrity is Prucalopride. 


    Before starting on Motegrity, be sure to speak with your doctor if you have any history of have or have had depression, suicidal thoughts or actions, changes in mood, kidney problems, or if you are pregnant or plan to become pregnant.


    Possibility of drug interaction risks between Motegrity and the following medications and supplements; mitriptyline, atorvastatin, baclofen, Cymbalta (duloxetine), famotidine, gabapentin, levothyroxine, Linzess (linaclotide), Lyrica (pregabalin), MiraLAX (polyethylene glycol 3350), omeprazole, ondansetron, pantoprazole, prednisone, promethazine, tramadol, trazodone, Vitamin B12 (cyanocobalamin), Vitamin D3 (cholecalciferol), and Zyrtec (cetirizine)

    Tell your doctor about all medications and supplements you are taking when meeting them to discuss constipation relief medications for CIC and before proceeding to buy Motegrity medication.

    Side Effects

    Motegrity side effects are uncommon, but some people may experience headache, abdominal pain or bloating, nausea, diarrhea, dizziness, vomiting, or gas and fatigue.

    Motegrity side effects that persist or become severe should lead you to discontinue use and visit your doctor to look at other chronic constipation treatment options.

    Frequently Asked Questions about Motegrity (Prucalopride)

    What is Motegrity (Prucalopride)?

    Motegrity, also known as prucalopride, is a serotonin-4 (5-HT4) receptor agonist used in the treatment of gastrointestinal disorders. It is a prescription medicine used to treat chronic idiopathic constipation.

    How does Motegrity work?

    Motegrity works by targeting the serotonin receptors in your colon that trigger natural contractions of your colon muscles (known as peristalsis). This helps push food through your digestive tract so that stool can pass more loosely and easily.

    What are the most common side effects of Motegrity?

    The most commonly reported side effects of Motegrity include nausea, abdominal pain, headache, and diarrhea.

    Why is Motegrity so expensive?

    The high price of Motegrity can be attributed to a range of factors, from research and development (R and D) and patents to production, distribution, and insurance coverage issues.

    How long does Motegrity stay in your system?

    The specific duration that Motegrity stays in your system is not clearly stated. Please consult with a healthcare provider for accurate information.

    How long does it take for Motegrity to start working?

    Motegrity starts to work after your first dose. You’ll likely have a bowel movement within a few days after taking the drug.

    Does Motegrity cause weight gain?

    No, weight gain was not reported as a side effect in Motegrity studies.

    How long can you take Motegrity?

    If you and your doctor determine that Motegrity is safe and effective for you, you may take the drug long term.

    What is the best time of day to take Motegrity?

    Motegrity can be taken at any time of the day, with or without food.

    Can you drink alcohol with Motegrity?

    There are no known interactions between Motegrity and alcohol, but your doctor might suggest avoiding alcohol while taking Motegrity because it could worsen some side effects.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13229

  • Product Reviews


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