What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Nitro-Dur (Nitroglycerin Transdermal)


Nitro-Dur (Nitroglycerin Transdermal)

Prescription Required


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  • Product Details


    Nitro-Dur (Nitroglycerin Transdermal) is a patch designed to deliver Nitroglycerin through the skin in a controlled manner. Nitroglycerin works as a vasodilator, acting on both arteries and veins. This medication is classified as a nitrate and is mainly used to prevent chest pain (angina) in people with coronary artery disease.

    Fact Table




    US FDA, US DailyMed, EU EMA


    Less than 1%

    Legal status


    Chemical Name

    Nitroglycerin Transdermal

    Elimination half-life

    1 to 4 minutes

    Dosage (Strength)

    0.4mg, 0.6mg, 0.8mg


    Consult a healthcare provider for advice



    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    Nitro-Dur is a transdermal medication, meaning it is administered through a patch applied directly to the skin. It is typically applied for 10 to 12 hours daily. The dosage may be adjusted by your doctor according to individual needs. When applying Nitro-Dur, wait until the skin is completely dry. The patch should be pressed firmly in place with the palm of your hand. Although showering, bathing, and swimming are permitted with the patch in place, the patch should be kept out of reach of children and pets.


    Nitro-Dur contains 1,2,3-propanetriol trinitrate as its primary active ingredient. The Nitro-Dur transdermal system uses acrylic-based polymer adhesives to hold the nitroglycerin. These adhesives allow for a sustained and controlled release of the medication.


    You may need to avoid this medication if any of the following apply:

    • You have had an allergy to Nitroglycerin or adhesive in the past.
    • You are taking erectile dysfunction medications, such as sildenafil, vardenafil, or tadalafil
    • You are taking pulmonary hypertension medications, like riociguat


    • When using Nitro-Dur, there are certain precautions that must be taken to ensure safe and effective use. Tell your healthcare provider about the following:
      • Other medications you take.
      • Other medical conditions you have.
      • Whether you are pregnant or breastfeeding.
    • Medications for erectile dysfunction, like sildenafil, can increase Nitro-Dur's effect on lowering blood pressure to dangerous levels.
    • If you have had a recent heart attack or heart failure, Nitro-Dur's safety and effectiveness for these conditions aren't well-known. Your doctor may closely monitor your condition if you're using it for these reasons.
    • Avoid placing a defibrillator (a device used in emergencies to restart the heart) over a Nitro-Dur patch. This can cause minor electrical sparks and possibly harm the skin.
    • Nitro-Dur can cause a significant drop in blood pressure, particularly when you stand up, which can be more severe in older adults or in people taking certain other medications.
    • Seniors should be extra cautious when using Nitro-Dur, as they may be more prone to the risks of low blood pressure, including the risk of falls.
    • For people with a certain heart condition known as hypertrophic cardiomyopathy, Nitro-Dur might make chest pain worse, so it's important to discuss this with your doctor.
    • People who have used nitrates for a long time might experience withdrawal symptoms like chest pain if they stop suddenly, suggesting a dependence on the medication.
    • Some studies have suggested that taking breaks from Nitro-Dur can lead to more chest pain or decreased ability to exercise. However, these effects are not well-understood and are considered rare.

    Side Effects

    Nitro-Dur may cause side effects. Common Nitroglycerin side effects can include headache, flushing, or redness of the skin, especially on the face and neck. Patients may also experience a feeling of warmth, dizziness, lightheadedness, sweating, and tingling sensations in the hands or feet. These side effects are generally mild and may diminish with continued use of the medication.

    Serious side effects associated with Nitro-Dur require prompt medical attention. Such side effects may include worsening chest pain, pounding heartbeats, and fluttering in the chest. Other severe symptoms may consist of a slow heart rate, feelings of lightheadedness that may lead to fainting, and symptoms indicative of a heart attack – like chest pain or pressure, pain spreading to the jaw or shoulder, nausea, and sweating. If you experience any of these serious side effects while using Nitro-Dur, seek medical advice immediately.


    1. Nitro-Dur (Nitroglycerin Transdermal) Product Monograph. Whitehouse Station, NJ: Merck & Co., Inc; 2014.
    2. Nitro-Dur (Nitroglycerin Transdermal) Drug Label Information. Orlando, FL: Ingenus Pharmaceuticals, LLC; 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1683

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