What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vagifem (Estradiol)
Prescription Required
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Product Details
Description
Vagifem is a topical estrogen used for the treatment of atrophic vaginitis due to menopause. Atrophic vaginitis symptoms include drying, inflammation, and thinning of the vaginal walls.
Vagifem is available by prescription from a licensed healthcare provider.
During menopause, the body's natural levels of estrogen decrease, causing changes in the vaginal walls. Vagifem helps to restore levels of estrogen and relieve the symptoms of vaginal atrophy.
Directions
Vagifem is inserted intravaginally using the included applicator.
Insert one 10 or 25 mcg tablet vaginally once daily for two weeks, followed by one tablet twice weekly.
Ingredients
The active ingredient in Vagifem is Estradiol. The generic name for Vagifem is also Estradiol.
Interactions
Vagifem is a topical medication, so very little absorbs into the bloodstream, and drug-drug interactions are unlikely. However, they can still occur under certain conditions. Tell your doctor or pharmacist if you are taking any of the following:
- Anastrazole
- Anticoagulants
- Apalutamide
- Carbamazepine
- Enzalutamide
- Exemestane
- Fosphenytoin
- Growth hormone analogs
- Mitotane
- Ospemifene
- Phenobarbital
- Phenytoin
- Pomalidomide
- Primidone
- Tipranavir
- Tizanidine
Fact Table
Formula
C18H24O2
License
EU EMA
Bioavailability
Oral: less than 5%
Legal status
RX Only
Chemical Name
Estradiol
Elimination half-life
Oral: 13–20 hours, Sublingual: 8–18 hours, Topical (gel): 36.5 hours
Dosage (Strength)
10mcg (18 tablets), 10mcg (36 tablets)
Pregnancy
Consult a doctor
Brands
Vagifem
Protein binding
98%
PubChem CID
5757
MedlinePlus
a601121
ChEBI
16469
ATC code
G03CA03
DrugBank
DB00783
KEGG
D00105
Routes of administration
Inserted
Cautions
Keep Vagimen out of reach of children.
You should not use Vagifem if you have any of the following:
- Known or suspected pregnancy
- Liver problems
- Active clotting disorder
- Known or suspected history of breast cancer
- Undiagnosed genital bleeding
This is not a full list of warnings. Speak with your doctor or pharmacist to learn if any precautions apply to you.
Side Effects
The most common Vagifem side effects may include:
- Abdominal pain
- Arthralgia
- Arthritis
- Back pain
- Bacterial vaginosis
- Diarrhea
- Flu-like symptoms
- Genital candidiasis
- Headache
- Hot flash
- Hypersensitivity reaction
- Insomnia
- Leukorrhea
- Mastalgia
- Migraine
- Nausea
- Pharyngitis
- Sinusitis
- Skeletal pain
- Stress
- Upper respiratory tract infection
- Urinary tract infection
- Urticaria
- Vaginal discomfort
- Vaginal hemorrhage
- Vaginal pain
- Vaginitis
- Vulvovaginal pruritus
References
Vagifem [package insert]. Princeton, NJ: Novo Nordisk; 2009.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2347
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