Description
Wellbutrin XL (bupropion extended-release) is a medication prescribed to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). MDD and SAD are mood disorders where a person experiences depressed moods (emptiness, sadness, etc.), decreased interest in normal activity, changes in sleep, changes in diet, low energy, difficulty concentrating, and similar symptoms that last for at least two weeks and often many months.
Wellbutrin XL works by increasing the levels of neurotransmitters dopamine and norepinephrine in certain parts of the brain. By increasing these neurotransmitters consistently over several weeks, Wellbutrin XL normalizes levels of these neurotransmitters, helping return the mood to normal.
Fact Table |
Formula |
C13H18ClNO |
License |
EU EMA, US FDA, US DailyMed |
Bioavailability |
Unknown |
Legal status |
Rx-Only |
Chemical Name |
Bupropion |
Elimination half-life |
11–21 h |
Dosage (Strength) |
150mg, 300mg |
Pregnancy |
Consult Doctor |
Brands |
Wellbutrin |
Protein binding |
84% |
PubChem CID |
444 |
MedlinePlus |
a695033 |
ChEBI |
3219 |
ATC code |
N06AX12 |
DrugBank |
DB01156 |
KEGG |
D07591 |
Routes of administration |
By mouth |
Directions
Take Wellbutrin XL once daily at the same time each day. The normal dosage ranges from 150-450 mg.
Note that other formulations of the active ingredient like Wellbutrin (bupropion immediate-release) and Wellbutrin SR (bupropion sustained-release) are not interchangeable with Wellbutrin XL.
Ingredients
The active ingredient in Wellbutrin XL is bupropion hydrochloride.
Cautions
Wellbutrin XL may increase the risk of seizures and should be used with caution in people with epilepsy or a history of seizures.
In some short-term studies, antidepressants increased the risk of suicidal ideation and action in children and young adults. Since depression itself is associated with suicidal thoughts and behaviors, this should not be a reason to forgo treatment. Friends and family members should be alert to suicidal thoughts and actions in patients that are starting antidepressants, but this risk does not remain over the long-term. Adults over 24 did not show an increased risk.
Side Effects
Wellbutrin XL side effects may include:
- Abdominal Pain
- Agitation
- Chest pain
- Constipation
- Diarrhea
- Dizziness
- Dry Mouth
- Flushing
- Insomnia
- Migraine
- Migraine
- Nausea
- Nausea
- Palpitation
- Rash
- Tremor
Not everyone who takes Wellbutrin XL experiences every side effects, and most people only experience one or two. Speak with your doctor for a full list of possible side effects.
References
- Wellbutrin XL. [package insert] Research Triangle Park, NC: GlaxoSmithKline; 2009.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 5494