What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Zaroxolyn (Metolazone)


Zaroxolyn (Metolazone)

Prescription Required


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Generic Equivalent - Zaroxolyn (Metolazone)

Prescription Required


You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details


    Zaroxolyn (metolazone) is a prescription medication used to treat edema, or swelling. It is also used to treat high blood pressure. The medication is classified as a diuretic, or fluid pill.

    Zaroxolyn comes in 2.5 mg, 5 mg, and 10 mg tablets for oral administration.

    Fact Table




    US DailyMed



    Legal status


    Chemical Name


    Elimination half-life

    14 hours

    Dosage (Strength)

    2.5mg, 5mg


    Consult Doctor


    Zaroxolyn is one of the brand names for metolazone. It may also be sold under other brand names.

    Protein binding

    Metolazone is moderately protein-bound, with approximately 40% to 50% binding to plasma proteins

    PubChem CID






    ATC code






    Routes of administration

    Metolazone is usually taken orally as a tablet


    Take Zaroxolyn exactly as your doctor has prescribed. If you have any questions or concerns, talk to your doctor or pharmacist.

    Zaroxolyn dose for high blood pressure:

    Take 2.5 mg to 5 mg by mouth once daily, up to 20 mg a day.

    Dosing for fluid retention:

    2.5 mg to 10 mg by mouth once daily, up to 20 mg a day.

    Older patients may need to take a lower dose.


    The active ingredient in Zaroxolyn is metolazone.


    Zaroxolyn should not be given to patients who are:

    • Allergic to metolazone or sulfonamides
    • Unable to produce urine

    In addition, patients who are in a hepatic coma or precoma should not receive Zaroxolyn.


    • Before you start taking Zaroxolyn, inform your doctor of:
      • All the medications you take
      • Your allergies
      • Your current health conditions and past medical history
      • Your pregnancy or breastfeeding status
      • Any upcoming surgeries or procedures
    • Patients with diabetes, high cholesterol, elevated uric acid levels or gout, low blood pressure, lupus, or liver disease should use Zaroxolyn with caution. Patients who have had a sympathectomy should also use Zaroxolyn with caution.
    • Zaroxolyn can worsen digitalis toxicity.
    • Zaroxolyn can cause photosensitivity.
    • High calcium, low potassium, low sodium, and low magnesium levels can occur with Zaroxolyn use.
    • Angioedema (swelling underneath the skin) or other allergic reactions can occur with Zaroloxyn use.
    • Patients with a sulfa allergy may exhibit allergic reactions due to cross-sensitivity; however, this may not occur or the risk is low.
    • Zaroxolyn can affect lipid and glucose metabolism.
    • Males may experience sexual dysfunction during treatment with Zaroxolyn.
    • Monitor for low blood pressure regularly, especially if you are also taking other blood pressure medications.
    • Patients with primary adrenal insufficiency should avoid taking Zaroxolyn for the treatment of high blood pressure. Adjustments of glucocorticoid/mineralocorticoid therapy or an alternative blood pressure medication is recommended.

    Side Effects

    Some Zaroxolyn side effects include chest pain, depression, dizziness, drowsiness, electrolyte abnormalities, glucose in the urine, gout attacks, headache, liver problems, high uric acid levels, joint pain, nerve pain, low blood pressure, pancreatitis, serious skin problems, fainting, and volume depletion; however, other side effects can also occur. Call your doctor if you have side effects that are bothersome or persistent.

    You can buy Zaroxolyn medication online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.


    Metolazone. Medscape.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 2403

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