What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Daypro (Oxaprozin)
Prescription Required
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Product Details
Description
Daypro is a prescription non-steroidal anti-inflammatory drug (NSAID) used to alleviate pain and inflammation caused by osteoarthritis (OA), rheumatoid arthritis (RA), and juvenile rheumatoid arthritis (JRA).
Daypro comes in 600 mg caplets for oral administration.
Directions
Take Daypro medication as instructed by your doctor. Tell your doctor or pharmacist if you have any questions or concerns about the medication.
The lowest effective dose should be used for the shortest amount of time. Each patient’s dose is individualized based on treatment goals.
Recommended dosing
OA: Take two 600 mg caplets (1200 mg) by mouth one time a day
RA: Take two 600 mg caplets (1200 mg) by mouth one time a day
JRA: 600 mg by mouth one time a day in patients who weigh 22-31 kg (48.4-68.2 lbs); 900 mg by mouth one time a day in patients who weigh 32-54 kg (70.4-118.8 lbs); 1200 mg by mouth one time a day in patients who weigh at least 55 kg (121 lbs)
Ingredients
Oxaprozin is the active ingredient in Daypro.
Microcrystalline cellulose, hypromellose, methylcellulose, magnesium stearate, polacrilin potassium, starch, polyethylene glycol, and titanium dioxide are the inactive ingredients.
Contraindications
Patients who are allergic to oxaprozin or to any of the other ingredients contained in Daypro should not take the medication.
Patients with a history of asthma, hives, or other allergic-type reactions after taking aspirin or other NSAIDs should not take Daypro.
Daypro should not be administered to patients undergoing coronary artery bypass graft (CABG) surgery.
Cautions
- Daypro has the following FDA Boxed Warning:
- NSAIDs increase the risk of serious cardiovascular thrombotic events such as heart attack and stroke, both of which can result in death. The risk can occur early in treatment and may increase with duration of use.
- Daypro should not be used in patients undergoing CABG.
- NSAIDs increase the risk of serious gastrointestinal (GI) adverse events such as bleeding, ulceration, and perforation of the stomach or intestines, which can result in death. These events can happen at any time during treatment and do not always present with warning symptoms. Older patients and patients who have had peptic ulcer disease and/or GI bleeding are at greater risk.
- Before you begin treatment with Daypro, inform your doctor of:
- All the medications you take
- Your allergies
- Your current health conditions
- Your past medical history
- Your pregnancy or breastfeeding status
- Daypro can cause liver damage. Warning signs and symptoms include nausea, fatigue, lethargy, diarrhea, itching, right upper quadrant tenderness, flu-like symptoms, and yellowing of the skin or whites of the eyes. Seek emergency care right away if you develop any of these signs and symptoms.
- Daypro may cause high blood pressure or worsen pre-existing high blood pressure. In addition, Daypro may impair the effects of some blood pressure medications. Blood pressure should be monitored.
- Daypro should not be used in patients with severe heart failure unless the benefits outweigh the risks.
- Daypro should not be used in patients with advanced kidney disease unless the benefits outweigh the risks.
- Anaphylactic reactions can occur with Daypro use. Seek emergency care right away if you have trouble breathing; swelling of the face, lips, tongue, or throat; a rash; or other symptoms of a serious allergic reaction.
- Daypro should not be used in patients with aspirin-sensitive asthma. Patients with asthma that is not aspirin-sensitive should be monitored.
- Serious skin reactions can occur with Daypro use. Stop taking Daypro and call your doctor right away if you develop a rash or other signs of a reaction.
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) can occur with Daypro use, resulting in signs and symptoms such as fever, rash, swollen lymph nodes, and/or facial swelling. Inflammation of the liver or kidney, bleeding disorders, inflammation of the heart muscle, or inflammation of muscle can also occur. DRESS can be life-threatening or result in death. Stop taking Daypro and seek emergency care right away if you experience any of these effects.
- NSAIDs including Daypro should be avoided in women who are at about 30 weeks pregnant and later, as they can cause harm to an unborn baby.
- NSAIDs like Daypro can cause anemia and increase the risk of bleeding. Be sure to watch out for symptoms of anemia or bleeding and seek medical care right away if you develop any symptoms.
Side Effects
Common Daypro side effects include constipation, diarrhea, indigestion, nausea, and rash; however, other side effects may also occur. Contact your doctor right away if you have side effects that worry you or won’t go away.
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Reference:
- Daypro. New York, NY: Pfizer Labs; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1453
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