What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Estring (Estradiol)

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Brand

Estring (Estradiol)

Prescription Required

Strength
Qty
2mg

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  • Product Details

    Description

    ESTRING (estradiol) is a medication prescribed to treat moderate to severe urogenital symptoms that are caused by postmenopause. ESTRING can treat symptoms of vaginal atrophy including: 

    • Burning
    • Dryness
    • Dyspareunia
    • Pruritis


    ESTRING can also treat symptoms that affect the lower urinary tract including:

    • Dysuria
    • Urinary urgency


    ESTRING contains the estrogen hormone estradiol, which releases approximately 7.5 micrograms every 24 hours. Estrogens are responsible for the maintenance of secondary sexual characteristics, and restoring estrogens levels can treat symptoms caused by the reduced estrogen that occurs during menopause.


    Fact Table

    Formula

    C18H24O2

    License

    EU EMA

    Bioavailability

    5%

    Legal status

    Rx-Only

    Chemical Name

    Estradiol

    Elimination half-life

    13 - 36.5 hours

    Dosage (Strength)

    2mg

    Pregnancy

    Consult Doctor

    Brands

    Estring

    Protein binding

    98%

    PubChem CID

    5757

    MedlinePlus

    a605041

    ChEBI

    16469

    ATC code

    G03CA03

    DrugBank

    DB00783

    KEGG

    D00105

    Routes of administration

    By mouth (tablets)

    Directions

    Insert ESTRING into the upper third of the vaginal canal and wear it continuously for 90 days. ESTRING is designed to continuously release medication over this period of time.

    ESTRING is an opaque ring with a whitish core.

    Ingredients

    The active ingredient in ESTRING is estradiol.

    Cautions

    ESTRING should not be used by women with a current clotting disorder or history of one. Examples include deep vein thrombosis (DVT), pulmonary embolism (PE), cardiovascular accident (stroke), or myocardial infarction (heart attack)

    Do not use ESTRING if you are pregnant, suspect you are pregnant or are trying to get pregnant.

    ESTRING should be used with caution in patients with impaired liver function.

    ESTRING may increase the risk of certain cancers like endometrial cancer, breast cancer, and ovarian cancer. Speak with your doctor about your risk before starting ESTRING.

    Side Effects

    Some of the most common ESTRING side effects include:

    • Abdominal pain
    • Arthritis
    • Back pain
    • Vaginitis
    • Headache
    • Insomnia
    • Nausea
    • Skeletal pain
    • Vaginal discomfort
    • Vaginal hemorrhage


    Speak with your doctor for a full list of side effects and warnings related to ESTRING.

    References

    1. Estring [package insert].New York, NY: Pfizer, 2018

    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1513

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