Description
ESTRING (estradiol) is a medication prescribed to treat moderate to severe urogenital symptoms that are caused by postmenopause. ESTRING can treat symptoms of vaginal atrophy including:
- Burning
- Dryness
- Dyspareunia
- Pruritis
ESTRING can also treat symptoms that affect the lower urinary tract including:
ESTRING contains the estrogen hormone estradiol, which releases approximately 7.5 micrograms every 24 hours. Estrogens are responsible for the maintenance of secondary sexual characteristics, and restoring estrogens levels can treat symptoms caused by the reduced estrogen that occurs during menopause.
Fact Table |
Formula |
C18H24O2 |
License |
EU EMA |
Bioavailability |
5% |
Legal status |
Rx-Only |
Chemical Name |
Estradiol |
Elimination half-life |
13 - 36.5 hours |
Dosage (Strength) |
2mg |
Pregnancy |
Consult Doctor |
Brands |
Estring |
Protein binding |
98% |
PubChem CID |
5757 |
MedlinePlus |
a605041 |
ChEBI |
16469 |
ATC code |
G03CA03 |
DrugBank |
DB00783 |
KEGG |
D00105 |
Routes of administration |
By mouth (tablets) |
Directions
Insert ESTRING into the upper third of the vaginal canal and wear it continuously for 90 days. ESTRING is designed to continuously release medication over this period of time.
ESTRING is an opaque ring with a whitish core.
Ingredients
The active ingredient in ESTRING is estradiol.
Cautions
ESTRING should not be used by women with a current clotting disorder or history of one. Examples include deep vein thrombosis (DVT), pulmonary embolism (PE), cardiovascular accident (stroke), or myocardial infarction (heart attack)
Do not use ESTRING if you are pregnant, suspect you are pregnant or are trying to get pregnant.
ESTRING should be used with caution in patients with impaired liver function.
ESTRING may increase the risk of certain cancers like endometrial cancer, breast cancer, and ovarian cancer. Speak with your doctor about your risk before starting ESTRING.
Side Effects
Some of the most common ESTRING side effects include:
- Abdominal pain
- Arthritis
- Back pain
- Vaginitis
- Headache
- Insomnia
- Nausea
- Skeletal pain
- Vaginal discomfort
- Vaginal hemorrhage
Speak with your doctor for a full list of side effects and warnings related to ESTRING.
References
- Estring [package insert].New York, NY: Pfizer, 2018
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1513