What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Estring (Estradiol)


Estring (Estradiol)

Prescription Required


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  • Product Details


    ESTRING (estradiol) is a medication prescribed to treat moderate to severe urogenital symptoms that are caused by postmenopause. ESTRING can treat symptoms of vaginal atrophy including: 

    • Burning
    • Dryness
    • Dyspareunia
    • Pruritis

    ESTRING can also treat symptoms that affect the lower urinary tract including:

    • Dysuria
    • Urinary urgency

    ESTRING contains the estrogen hormone estradiol, which releases approximately 7.5 micrograms every 24 hours. Estrogens are responsible for the maintenance of secondary sexual characteristics, and restoring estrogens levels can treat symptoms caused by the reduced estrogen that occurs during menopause.

    Fact Table




    EU EMA



    Legal status


    Chemical Name


    Elimination half-life

    13 - 36.5 hours

    Dosage (Strength)



    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth (tablets)


    Insert ESTRING into the upper third of the vaginal canal and wear it continuously for 90 days. ESTRING is designed to continuously release medication over this period of time.

    ESTRING is an opaque ring with a whitish core.


    The active ingredient in ESTRING is estradiol.


    ESTRING should not be used by women with a current clotting disorder or history of one. Examples include deep vein thrombosis (DVT), pulmonary embolism (PE), cardiovascular accident (stroke), or myocardial infarction (heart attack)

    Do not use ESTRING if you are pregnant, suspect you are pregnant or are trying to get pregnant.

    ESTRING should be used with caution in patients with impaired liver function.

    ESTRING may increase the risk of certain cancers like endometrial cancer, breast cancer, and ovarian cancer. Speak with your doctor about your risk before starting ESTRING.

    Side Effects

    Some of the most common ESTRING side effects include:

    • Abdominal pain
    • Arthritis
    • Back pain
    • Vaginitis
    • Headache
    • Insomnia
    • Nausea
    • Skeletal pain
    • Vaginal discomfort
    • Vaginal hemorrhage

    Speak with your doctor for a full list of side effects and warnings related to ESTRING.


    1. Estring [package insert].New York, NY: Pfizer, 2018

    Frequently Asked Questions about Estring (Estradiol)

    What is Estring used for?

    Estring (estradiol) is a vaginal ring that reduces symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. It’s also used for atrophic vaginitis and urethritis.

    How long does it take for Estring to work?

    You should start feeling relief from vaginal dryness and burning within 2 to 3 weeks after starting Estring.

    Is weight gain a side effect of Estring?

    Weight gain is not a common side effect of Estring.

    How long can you stay on Estring?

    Estring remains in place for 90 days. After that, it should be removed and replaced with a new ring if continued therapy is needed.

    Is Estring stronger than Vagifem?

    Estring releases a slightly stronger dose of estrogen than Vagifem. Both are used for similar purposes.

    Is Estring considered hormone replacement therapy (HRT)?

    Yes, Estring is a form of hormone replacement therapy (HRT) for menopausal symptoms.

    What age should you stop taking estradiol?

    The decision to stop taking estradiol depends on individual health and needs. Regular discussions with your healthcare provider are essential.

    Is Estring uncomfortable?

    Estring should not cause discomfort when properly inserted. If you feel any discomfort, adjust its position gently.

    What should I avoid while taking estradiol?

    Avoid smoking, alcohol abuse, and prolonged sun exposure. Discuss specific concerns with your doctor.

    How do you insert Estring?

    Insert Estring into the vagina using clean hands. It should remain in the upper third of the vagina. Replace it every 90 days.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1513

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