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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Glucovance (Glyburide/Metformin)

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Brand

Glucovance (Glyburide/Metformin)

Prescription Required

Strength

1.25mg/250mg

2.5mg/500mg

5mg/500mg

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  • Product Details

    Description

    GLUCOVANCE (glyburide/metformin) is a prescription medication that treats Type 2 Diabetes Mellitus. GLUCOVANCE contains two different medications that work in different ways.

    People with diabetes cannot regulate their blood sugar normally, so they may experience hyperglycemia (high blood sugar). Hyperglycemia can cause damage to different organs, including the kidneys, eyes, feet, and skin.

    Directions

    The starting GLUCOVANCE dosage is one 1.25/250 mg tablet by mouth once or twice daily.

    The dosage can be increased to a maximum of 20/2000 mg per day, divided into multiple doses.

    Take GLUCOVANCE with meals. Skipping a meal after taking GLUCOVANCE will increase the risk of hyperglycemia.

    Ingredients

    GLUCOVANCE is a combination antidiabetic tablet. It contains the active ingredients metformin and glyburide.

    Metformin works by lowering the amount of glucose produced by the liver, reducing the amount absorbed during meals, and by making the body more sensitive to insulin.

    Glyburide works by stimulating the pancreas to release additional insulin.

    Interactions

    Tell your healthcare provider if you are taking any of the following medications:

    • Bosentan
    • Calcium channel blocking agents
    • Chloramphenicol
    • Corticosteroids
    • Diuretics
    • Estrogens
    • Isoniazid
    • Monoamine oxidase inhibitors (MAOIs)
    • Nicotinic acid
    • NSAIDs
    • Oral contraceptives
    • Phenothiazines
    • Phenytoin
    • Probenecid
    • Sulfonamides
    • Sympathomimetics
    • Thyroid products
    • Warfarin

    Cautions

    Lactic acidosis is a rare and serious side effect of metformin. Ask your doctor or pharmacist to review the symptoms of lactic acidosis.

    Glyburide can increase the incidence of low blood sugar (hypoglycemia). Do not skip a meal after taking GLUCOVANCE.

    The incidence of hemolytic anemia is higher in patients with a history of G6PD deficiency.

    Side Effects

    Common adverse reactions to GLUCOVANCE are:

    • Diarrhea
    • Dizziness
    • Gastrointestinal symptoms
    • Headache
    • Hypoglycemia
    • Upper respiratory infection

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    References

    Glucovance [package insert].Princeton, NJ: Bristol-Myers Squibb; 2013.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 2576

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