What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Glucovance (Glyburide/Metformin)


Glucovance (Glyburide/Metformin)

Prescription Required

1.25mg / 250mg
2.5mg / 500mg
5mg / 500mg

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  • Product Details


    GLUCOVANCE (glyburide/metformin) is a prescription medication that treats Type 2 Diabetes Mellitus. GLUCOVANCE contains two different medications that work in different ways.

    People with diabetes cannot regulate their blood sugar normally, so they may experience hyperglycemia (high blood sugar). Hyperglycemia can cause damage to different organs, including the kidneys, eyes, feet, and skin.


    The starting GLUCOVANCE dosage is one 1.25/250 mg tablet by mouth once or twice daily.

    The dosage can be increased to a maximum of 20/2000 mg per day, divided into multiple doses.

    Take GLUCOVANCE with meals. Skipping a meal after taking GLUCOVANCE will increase the risk of hyperglycemia.


    GLUCOVANCE is a combination antidiabetic tablet. It contains the active ingredients metformin and glyburide.

    Metformin works by lowering the amount of glucose produced by the liver, reducing the amount absorbed during meals, and by making the body more sensitive to insulin.

    Glyburide works by stimulating the pancreas to release additional insulin.

    Fact Table







    Legal status

    RX Only

    Chemical Name

    Glibenclamide, Metformin

    Elimination half-life

    6.2 hours

    Dosage (Strength)

    1.25mg/250mg (90 tablets), 2.5mg/500mg (90 tablets), 5mg/500mg (90 tablets)


    Consult a doctor


    Diabeta, Glucovance, Glynase

    Protein binding


    PubChem CID





    Glibenclamide: 5441, Metformin: 6801

    ATC code



    Glibenclamide: DB01016, Metformin: DB00331


    Glibenclamide: DB00331, Metformin: D04966

    Routes of administration

    By mouth (tablets)


    Tell your healthcare provider if you are taking any of the following medications:

    • Bosentan
    • Calcium channel blocking agents
    • Chloramphenicol
    • Corticosteroids
    • Diuretics
    • Estrogens
    • Isoniazid
    • Monoamine oxidase inhibitors (MAOIs)
    • Nicotinic acid
    • NSAIDs
    • Oral contraceptives
    • Phenothiazines
    • Phenytoin
    • Probenecid
    • Sulfonamides
    • Sympathomimetics
    • Thyroid products
    • Warfarin


    Lactic acidosis is a rare and serious side effect of metformin. Ask your doctor or pharmacist to review the symptoms of lactic acidosis.

    Glyburide can increase the incidence of low blood sugar (hypoglycemia). Do not skip a meal after taking GLUCOVANCE.

    The incidence of hemolytic anemia is higher in patients with a history of G6PD deficiency.

    Side Effects

    Common adverse reactions to GLUCOVANCE are:

    • Diarrhea
    • Dizziness
    • Gastrointestinal symptoms
    • Headache
    • Hypoglycemia
    • Upper respiratory infection


    Glucovance [package insert].Princeton, NJ: Bristol-Myers Squibb; 2013.

    Frequently Asked Questions about Glucovance

    What is Glucovance?

    Glucovance is a combination medication containing two active ingredients: glyburide and metformin. It is used to treat type 2 diabetes.

    How does Glucovance work?

    Glucovance combines the actions of glyburide, a sulfonylurea, and metformin, a biguanide. Glyburide helps the pancreas produce more insulin, while metformin reduces the amount of glucose produced by the liver and improves insulin sensitivity in the body.

    How should I take Glucovance?

    Always take Glucovance as prescribed by your doctor. It is usually taken with meals to reduce the risk of stomach upset.

    What are the potential side effects of Glucovance?

    Common side effects include nausea, upset stomach, diarrhea, and low blood sugar. If you experience symptoms of lactic acidosis (such as muscle pain, difficulty breathing, slow or irregular heartbeat), seek medical attention immediately.

    Can I drink alcohol while taking Glucovance?

    It's best to avoid alcohol while on Glucovance, as it can increase the risk of lactic acidosis and low blood sugar.

    Who should not take Glucovance?

    People with severe kidney problems, certain metabolic conditions, or those allergic to either glyburide or metformin should not take Glucovance.

    Can I take Glucovance during pregnancy?

    Consult your doctor if you are pregnant or planning to become pregnant. Glucovance may not be suitable for use during pregnancy.

    How should I store Glucovance?

    Store Glucovance at room temperature, away from moisture and heat. Keep out of reach of children.

    What should I do if I miss a dose?

    If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

    Can I take other medications with Glucovance?

    Always inform your doctor of all medications you are taking, including over-the-counter drugs and supplements. Some medications may interact with Glucovance.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 2576

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