Description
Your doctor may prescribe indomethacin to treat different types of pain. It can be used for: moderate to severe rheumatoid arthritis, including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder, and acute gouty arthritis.
The medication belongs to the class non-steroidal anti-inflammatory drugs (NSAIDs). These types of medication are non-narcotic pain medications and can be used for a variety of conditions.
Fact Table |
Formula |
C19H16ClNO4 |
License |
US FDA |
Bioavailability |
~100% |
Legal status |
Rx-only |
Chemical Name |
Indometacin |
Elimination half-life |
2.6-11.2 hours |
Dosage (Strength) |
25mg, 50mg |
Pregnancy |
Not Recommended |
Brands |
Indocid, Indocin |
Protein binding |
99% |
PubChem CID |
3715 |
MedlinePlus |
a681027 |
ChEBI |
49662 |
ATC code |
C01EB03 |
DrugBank |
DB00328 |
KEGG |
D00141 |
Routes of administration |
By mouth |
Directions
Take Indomethacin exactly as prescribed by your doctor based on the condition being treated. The standard dosage varies from 25-50 mg up to three times daily.
Ingredients
The active ingredient is indomethacin.
Interactions
There are many potential drug-drug interactions with indomethacin. Please tell your doctor and pharmacist if you are taking any of the following:
- Acemetacin
- Aminolevulinic Acid
- Apixaban
- Bemiparin
- CycloSPORINE
- Dabigatran Etexilate
- Diflunisal
- Edoxaban
- Enoxaparin
- Heparin
- Ketorolac
- Lithium
- Loop Diuretics
- Macimorelin
- Methotrexate
- Mifamurtide
- Nonsteroidal Anti-Inflammatory Agents
- Phenylbutazone
- PRALAtrexate
- Rivaroxaban
- Salicylates
- Selective Serotonin Reuptake Inhibitors
- Sincalide
- Sodium Phosphates
- Tenofovir Products
- Tenoxicam
- Tiludronate
- Triamterene
- Urokinase
- Vitamin K Antagonists
Cautions
Before starting indomethacin, you should tell your doctor if you have a history of kidney disease, liver disease, heart disease, or heart failure.
Indomethacin and other NSAIDs should only be used for the shortest amount of time at the lowest possible doses.
Stop Indomethacin and tell your doctor right away if you develop if skin rash while taking this drug.
Side Effects
Some of the most common Indomethacin side effects may include:
- Abdominal distress
- Abdominal pain
- Alopecia
- Anorexia
- Bloating
- Chest pain
- Constipation
- Decreased appetite
- Depression
- Diaphoresis
- Diarrhea
- Dizziness
- Drowsiness
- Dyspepsia
- Epigastric pain
- Fatigue
- Gastroenteritis
- Headache
- Heartburn
- Hot flash
- Hyperhidrosis
- Hypertension
- Malaise
- Nausea
- Pancreatitis
- Postoperative hemorrhage
- Presyncope
- Pruritus
- Skin Rash
- Swelling
- Syncope
- Tinnitus
- Vertigo
- Vomiting
References
Indomethacin, Philadelphia, PA: Iroko Pharmaceuticals, LLC; 2016.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1575