What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Indocin (Indomethacin)


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Generic Equivalent - Indocin (Indomethacin)

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  • Product Details


    Your doctor may prescribe indomethacin to treat different types of pain. It can be used for: moderate to severe rheumatoid arthritis, including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder, and acute gouty arthritis.

    The medication belongs to the class non-steroidal anti-inflammatory drugs (NSAIDs). These types of medication are non-narcotic pain medications and can be used for a variety of conditions.

    Fact Table




    US FDA



    Legal status


    Chemical Name


    Elimination half-life

    2.6-11.2 hours

    Dosage (Strength)

    25mg, 50mg


    Not Recommended


    Indocid, Indocin

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth


    Take Indomethacin exactly as prescribed by your doctor based on the condition being treated. The standard dosage varies from 25-50 mg up to three times daily.


    The active ingredient is indomethacin.


    There are many potential drug-drug interactions with indomethacin. Please tell your doctor and pharmacist if you are taking any of the following:

    • Acemetacin
    • Aminolevulinic Acid
    • Apixaban
    • Bemiparin
    • CycloSPORINE 
    • Dabigatran Etexilate
    • Diflunisal
    • Edoxaban
    • Enoxaparin
    • Heparin
    • Ketorolac
    • Lithium
    • Loop Diuretics
    • Macimorelin
    • Methotrexate
    • Mifamurtide
    • Nonsteroidal Anti-Inflammatory Agents
    • Phenylbutazone
    • PRALAtrexate
    • Rivaroxaban
    • Salicylates
    • Selective Serotonin Reuptake Inhibitors
    • Sincalide
    • Sodium Phosphates
    • Tenofovir Products
    • Tenoxicam
    • Tiludronate
    • Triamterene
    • Urokinase
    • Vitamin K Antagonists


    Before starting indomethacin, you should tell your doctor if you have a history of kidney disease, liver disease, heart disease, or heart failure.

    Indomethacin and other NSAIDs should only be used for the shortest amount of time at the lowest possible doses.

    Stop Indomethacin and tell your doctor right away if you develop if skin rash while taking this drug.

    Side Effects

    Some of the most common Indomethacin side effects may include:

    • Abdominal distress
    • Abdominal pain
    • Alopecia
    • Anorexia
    • Bloating
    • Chest pain
    • Constipation
    • Decreased appetite
    • Depression
    • Diaphoresis
    • Diarrhea
    • Dizziness
    • Drowsiness
    • Dyspepsia
    • Epigastric pain
    • Fatigue
    • Gastroenteritis
    • Headache
    • Heartburn
    • Hot flash
    • Hyperhidrosis
    • Hypertension
    • Malaise
    • Nausea
    • Pancreatitis
    • Postoperative hemorrhage
    • Presyncope
    • Pruritus
    • Skin Rash
    • Swelling
    • Syncope
    • Tinnitus
    • Vertigo
    • Vomiting


    Indomethacin, Philadelphia, PA: Iroko Pharmaceuticals, LLC; 2016.

    Frequently Asked Questions about Indomethacin

    What is Indomethacin?

    Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce inflammation and relieve pain. It is commonly prescribed to treat conditions such as arthritis, gout, and certain types of pain.

    How does Indomethacin work?

    Indomethacin works by inhibiting the production of chemicals in the body that cause inflammation and pain. It helps to reduce swelling, pain, and stiffness associated with various medical conditions.

    What conditions are typically treated with Indomethacin?

    Indomethacin is often prescribed to treat conditions such as rheumatoid arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis, and certain types of pain, including menstrual pain.

    How should I take Indomethacin?

    It's crucial to follow your healthcare provider's instructions when taking Indomethacin. Typically, it is taken with food or milk to reduce stomach upset. The dosage and duration of treatment will depend on your specific condition.

    What are the potential side effects of Indomethacin?

    Common side effects of Indomethacin may include stomach pain, heartburn, nausea, headache, dizziness, and changes in blood pressure. Serious side effects such as gastrointestinal bleeding or allergic reactions are possible and should be reported to a healthcare provider.

    Are there any drug interactions with Indomethacin?

    Indomethacin may interact with certain medications, including other NSAIDs, blood thinners, and some high blood pressure medications. Always inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.

    Can I drink alcohol while taking Indomethacin?

    It is generally advisable to limit alcohol consumption while taking Indomethacin, as alcohol can increase the risk of stomach irritation and gastrointestinal bleeding associated with this medication.

    How long can I take Indomethacin?

    The duration of Indomethacin treatment will depend on your medical condition and the recommendations of your healthcare provider. It is essential to follow their guidance and not exceed the prescribed duration without consulting them.

    Can I stop taking Indomethacin suddenly?

    It is not recommended to stop taking Indomethacin abruptly without consulting your healthcare provider, especially if you have been taking it for an extended period. They can provide guidance on how to taper the medication if necessary.

    Is Indomethacin available over the counter (OTC)?

    Indomethacin is typically available by prescription only. You will need to consult a healthcare provider to obtain this medication.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 1575

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